Immunogenetic markers of Crohn's disease in adults population of the Moscow region
<p>Aim: to study immunogenetic markers of predisposition to the development and protection for Crohn's disease in adults population of the Moscow region. Material and methods. The study included 53 samples of peripheral blood of patients with Crohn's disease in the Moscow region. The...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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Saratov State Medical University
2014-12-01
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| Series: | Саратовский научно-медицинский журнал |
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| Online Access: | http://www.ssmj.ru/system/files/2014_04-01_743-749.pdf |
| _version_ | 1819031963290304512 |
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| author | Stavtsev D.S. Astrelina Т.А. Azova M.M. Lebedeva L.L. Pukhlikova T.V. Chumak A.A. Knyazev O.V. Eremin I.I. Gilmutdinova I.R. Kotenko K.V. |
| author_facet | Stavtsev D.S. Astrelina Т.А. Azova M.M. Lebedeva L.L. Pukhlikova T.V. Chumak A.A. Knyazev O.V. Eremin I.I. Gilmutdinova I.R. Kotenko K.V. |
| author_sort | Stavtsev D.S. |
| collection | DOAJ |
| description | <p>Aim: to study immunogenetic markers of predisposition to the development and protection for Crohn's disease in adults population of the Moscow region. Material and methods. The study included 53 samples of peripheral blood of patients with Crohn's disease in the Moscow region. The control group was represented by 1,700 samples of umbilical cord blood is healthy newborns. Revealing HLA antigens at low level performed by SSO method on DynalRELI 48 processor. The results received with ambiguous interpretation was using PCR-SSP method (Ivitrogen). Results. Were found the positive and negative associations of groups of HLA alleles with clinical form, the course of Crohn's disease and response to steroid treatment, in particular revealed that, predisposition to the development for Crohn's disease in women and with sensitivity to steroid treatment in this disease associated allele group C*12, to the characteristic restricting markers such as Crohn's disease include the В 38 and A*11 markers nonrestricting, nonpenetrating noninflammatory type groups are alleles B*56 and C*14 and C*14 is also associated with the risk of Crohn's disease in men, characteristic markers of protection to the development of the disease crown with chronic relapsing and severe clinical course are DQB1*02 and DQB1*03, respectively. Conclusion. These results demonstrate the need for studies of gene polymorphism HLA-system, not only in relation to the disease in general, but in selected patients with clinical groups.</p> |
| first_indexed | 2024-12-21T06:54:24Z |
| format | Article |
| id | doaj.art-262c6a027b9c46eda78e0bcb2d127153 |
| institution | Directory Open Access Journal |
| issn | 2076-2518 |
| language | Russian |
| last_indexed | 2024-12-21T06:54:24Z |
| publishDate | 2014-12-01 |
| publisher | Saratov State Medical University |
| record_format | Article |
| series | Саратовский научно-медицинский журнал |
| spelling | doaj.art-262c6a027b9c46eda78e0bcb2d1271532022-12-21T19:12:22ZrusSaratov State Medical UniversityСаратовский научно-медицинский журнал2076-25182014-12-011047437493899Immunogenetic markers of Crohn's disease in adults population of the Moscow regionStavtsev D.S.0Astrelina Т.А.1Azova M.M.2Lebedeva L.L.3Pukhlikova T.V.4Chumak A.A.5Knyazev O.V.6Eremin I.I.7Gilmutdinova I.R.8Kotenko K.V.9State Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological AgencyState Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological AgencyState Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological AgencyState Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological AgencyState Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological AgencyState Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological AgencyState Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological AgencyState Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological AgencyState Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological AgencyState Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological Agency<p>Aim: to study immunogenetic markers of predisposition to the development and protection for Crohn's disease in adults population of the Moscow region. Material and methods. The study included 53 samples of peripheral blood of patients with Crohn's disease in the Moscow region. The control group was represented by 1,700 samples of umbilical cord blood is healthy newborns. Revealing HLA antigens at low level performed by SSO method on DynalRELI 48 processor. The results received with ambiguous interpretation was using PCR-SSP method (Ivitrogen). Results. Were found the positive and negative associations of groups of HLA alleles with clinical form, the course of Crohn's disease and response to steroid treatment, in particular revealed that, predisposition to the development for Crohn's disease in women and with sensitivity to steroid treatment in this disease associated allele group C*12, to the characteristic restricting markers such as Crohn's disease include the В 38 and A*11 markers nonrestricting, nonpenetrating noninflammatory type groups are alleles B*56 and C*14 and C*14 is also associated with the risk of Crohn's disease in men, characteristic markers of protection to the development of the disease crown with chronic relapsing and severe clinical course are DQB1*02 and DQB1*03, respectively. Conclusion. These results demonstrate the need for studies of gene polymorphism HLA-system, not only in relation to the disease in general, but in selected patients with clinical groups.</p>http://www.ssmj.ru/system/files/2014_04-01_743-749.pdfCrohn’s diseaseHLA-antigensimmunogenetic markers |
| spellingShingle | Stavtsev D.S. Astrelina Т.А. Azova M.M. Lebedeva L.L. Pukhlikova T.V. Chumak A.A. Knyazev O.V. Eremin I.I. Gilmutdinova I.R. Kotenko K.V. Immunogenetic markers of Crohn's disease in adults population of the Moscow region Саратовский научно-медицинский журнал Crohn’s disease HLA-antigens immunogenetic markers |
| title | Immunogenetic markers of Crohn's disease in adults population of the Moscow region |
| title_full | Immunogenetic markers of Crohn's disease in adults population of the Moscow region |
| title_fullStr | Immunogenetic markers of Crohn's disease in adults population of the Moscow region |
| title_full_unstemmed | Immunogenetic markers of Crohn's disease in adults population of the Moscow region |
| title_short | Immunogenetic markers of Crohn's disease in adults population of the Moscow region |
| title_sort | immunogenetic markers of crohn s disease in adults population of the moscow region |
| topic | Crohn’s disease HLA-antigens immunogenetic markers |
| url | http://www.ssmj.ru/system/files/2014_04-01_743-749.pdf |
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