Intrahippocampal injection of irisin ameliorates depression-like behaviors in mice
Objective To investigate the effects of irisin on the depression-like behaviors in depression mice. Methods C57BL/6 mice were randomly divided into model and healthy groups. Mice in the model group were trained by open-space forced swim (OSFS) model and then were sub-divided into “model-control” a...
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| Format: | Article |
| Language: | zho |
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Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
2022-12-01
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| Series: | Jichu yixue yu linchuang |
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| Online Access: | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2022-42-12-1850.pdf |
| _version_ | 1827390572314230784 |
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| author | LI Jing, HUANG Bing-xuan, XU Qi |
| author_facet | LI Jing, HUANG Bing-xuan, XU Qi |
| author_sort | LI Jing, HUANG Bing-xuan, XU Qi |
| collection | DOAJ |
| description | Objective To investigate the effects of irisin on the depression-like behaviors in depression mice. Methods C57BL/6 mice were randomly divided into model and healthy groups. Mice in the model group were trained by open-space forced swim (OSFS) model and then were sub-divided into “model-control” and “model-irisin”. Healthy wild mice were bred normally and sub-divided into “healthy-control” and “healthy-irisin”groups. All mice in test group and in control groups were injected with 77 pmol irisin or the solvent (PBS) into both hippocampi by brain stereotactic injection, respectively. Depression-like behaviors were examined by forced swim test (FST) and tail suspension test (TST). Results Compared with the healthy ones, the model mice showed a markedly prolonged immobility time in FST(P＜0.01) and TST(P＜0.05), which indicated that the successfully established model can simulate the despair-like behaviors of patients with depression. Compared with the “model-control”, irisin can remarkably reduce the immobility time of “model-irisin” mice in FST(P＜0.001) and TST(P＜0.05). Conclusions Irisin can significantly improve the depression-like behaviors of OSFS depression mice. |
| first_indexed | 2024-03-08T16:54:39Z |
| format | Article |
| id | doaj.art-262d16b1034142d2a3f2e48b23753991 |
| institution | Directory Open Access Journal |
| issn | 1001-6325 |
| language | zho |
| last_indexed | 2024-03-08T16:54:39Z |
| publishDate | 2022-12-01 |
| publisher | Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. |
| record_format | Article |
| series | Jichu yixue yu linchuang |
| spelling | doaj.art-262d16b1034142d2a3f2e48b237539912024-01-05T02:36:47ZzhoInstitute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.Jichu yixue yu linchuang1001-63252022-12-0142121850185410.16352/j.issn.1001-6325.2022.12.1850Intrahippocampal injection of irisin ameliorates depression-like behaviors in miceLI Jing, HUANG Bing-xuan, XU Qi01. Department of Biochemistry and Molecular Biology, Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences CAMS, School of Basic Medicine PUMC, Beijing 100005; ;2. Beijing No. 166 High School, Beijing 100006, ChinaObjective To investigate the effects of irisin on the depression-like behaviors in depression mice. Methods C57BL/6 mice were randomly divided into model and healthy groups. Mice in the model group were trained by open-space forced swim (OSFS) model and then were sub-divided into “model-control” and “model-irisin”. Healthy wild mice were bred normally and sub-divided into “healthy-control” and “healthy-irisin”groups. All mice in test group and in control groups were injected with 77 pmol irisin or the solvent (PBS) into both hippocampi by brain stereotactic injection, respectively. Depression-like behaviors were examined by forced swim test (FST) and tail suspension test (TST). Results Compared with the healthy ones, the model mice showed a markedly prolonged immobility time in FST(P＜0.01) and TST(P＜0.05), which indicated that the successfully established model can simulate the despair-like behaviors of patients with depression. Compared with the “model-control”, irisin can remarkably reduce the immobility time of “model-irisin” mice in FST(P＜0.001) and TST(P＜0.05). Conclusions Irisin can significantly improve the depression-like behaviors of OSFS depression mice.http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2022-42-12-1850.pdfirisin|depression|physical exercise|antidepressant |
| spellingShingle | LI Jing, HUANG Bing-xuan, XU Qi Intrahippocampal injection of irisin ameliorates depression-like behaviors in mice Jichu yixue yu linchuang irisin|depression|physical exercise|antidepressant |
| title | Intrahippocampal injection of irisin ameliorates depression-like behaviors in mice |
| title_full | Intrahippocampal injection of irisin ameliorates depression-like behaviors in mice |
| title_fullStr | Intrahippocampal injection of irisin ameliorates depression-like behaviors in mice |
| title_full_unstemmed | Intrahippocampal injection of irisin ameliorates depression-like behaviors in mice |
| title_short | Intrahippocampal injection of irisin ameliorates depression-like behaviors in mice |
| title_sort | intrahippocampal injection of irisin ameliorates depression like behaviors in mice |
| topic | irisin|depression|physical exercise|antidepressant |
| url | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2022-42-12-1850.pdf |
| work_keys_str_mv | AT lijinghuangbingxuanxuqi intrahippocampalinjectionofirisinamelioratesdepressionlikebehaviorsinmice |