Enhanced Supersaturation and Oral Absorption of Sirolimus Using an Amorphous Solid Dispersion Based on Eudragit® E

Enhanced Supersaturation and Oral Absorption of Sirolimus Using an Amorphous Solid Dispersion Based on Eudragit® E

The present study aimed to investigate the effect of Eudragit® E/HCl (E-SD) on the degradation of sirolimus in simulated gastric fluid (pH 1.2) and to develop a new oral formulation of sirolimus using E-SD solid dispersions to enhance oral bioavailability. Sirolimus-loaded solid dispersions were fab...

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Bibliographic Details
Main Authors: Youngseok Cho, Eun-Sol Ha, In-Hwan Baek, Min-Soo Kim, Cheong-Weon Cho, Sung-Joo Hwang
Format: Article
Language:English
Published: MDPI AG 2015-05-01
Series:Molecules
Subjects:
sirolimus
supersaturation
bioavailability
Eudragit® E
solid dispersion
Online Access:http://www.mdpi.com/1420-3049/20/6/9496

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