Evolutionary Origin of <i>MUTYH</i> Germline Pathogenic Variations in Modern Humans

Evolutionary Origin of <i>MUTYH</i> Germline Pathogenic Variations in Modern Humans

MUTYH plays an essential role in preventing oxidation-caused DNA damage. Pathogenic germline variations in <i>MUTYH</i> damage its function, causing intestinal polyposis and colorectal cancer. Determination of the evolutionary origin of the variation is essential to understanding the eti...

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Bibliographic Details
Main Authors: Fengxia Xiao, Jiaheng Li, Philip Naderev Panuringan Lagniton, Si Hoi Kou, Huijun Lei, Benjamin Tam, San Ming Wang
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Biomolecules
Subjects:
<i>MUTYH</i>
pathogenic variant
evolutionary origin
phylogenic
archaeological
ancient humans
Online Access:https://www.mdpi.com/2218-273X/13/3/429

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