Comparison of Antifungal Efficacy of Zataria Multiflora and Nystatin for Treatment of Denture Stomatitis: A Randomized Clinical Trial
Statement of the Problem: Zataria multiflora (ZM) is a thyme-like plant that belongs to the Lamiaceae family. It is native to the center and south of Iran, Pakistan, and Afghanistan. Evidence shows that ZM contains thymol and carvacrol and is therefore, effective for the treatment of many conditions...
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| Format: | Article |
| Language: | English |
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Shiraz University of Medical Sciences
2021-03-01
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| Series: | Journal of Dentistry |
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| Online Access: | https://dentjods.sums.ac.ir/article_46918.html |
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| author | Elnaz Gonoudi Masoud Rezai Taraneh Farrokhnia Mehdi Goudarzi Alireza Sima |
| author_facet | Elnaz Gonoudi Masoud Rezai Taraneh Farrokhnia Mehdi Goudarzi Alireza Sima |
| author_sort | Elnaz Gonoudi |
| collection | DOAJ |
| description | Statement of the Problem: Zataria multiflora (ZM) is a thyme-like plant that belongs to the Lamiaceae family. It is native to the center and south of Iran, Pakistan, and Afghanistan. Evidence shows that ZM contains thymol and carvacrol and is therefore, effective for the treatment of many conditions especially fungal infections. Oral candidiasis is the most common opportunistic infection of the oral mucosa that plays a role in the development of denture stomatitis.
Purpose: This study aimed to compare the antifungal efficacy of ZM and nystatin suspension for the treatment of denture stomatitis.
Materials and Method: This single-blind clinical trial evaluated 28 patients (> 18 years old) suffering from type II or III denture stomatitis. Patients were divided into two groups. The control group used nystatin suspension while the case group used ZM drop. The number of Candida albicans (C. albicans) colony-forming units (CFUs) and erythema of the palate were evaluated at baseline and at 14 days after treatment. Data were analyzed using SPSS version 11 via Student’s t test and repeated measure ANOVA.
Results: The results showed similar efficacy of nystatin and ZM in the reduction of C.albicans CFUs compared to the baseline value (p= 0.593). Both medications significantly decreased the colony count (p< 0.001). Nystatin and ZM had similar efficacy for the reduction of erythema as well (p= 0.256) and both caused a significant reduction in erythema of the palate (p<0.001).
Conclusion: ZM drop was as effective as the nystatin drop in the resolution of erythema of the palate and reduction of C. albicans colony count. |
| first_indexed | 2024-12-14T09:19:44Z |
| format | Article |
| id | doaj.art-2631f535e30843a5a1973c9d6c525568 |
| institution | Directory Open Access Journal |
| issn | 2345-6485 2345-6418 |
| language | English |
| last_indexed | 2024-12-14T09:19:44Z |
| publishDate | 2021-03-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Journal of Dentistry |
| spelling | doaj.art-2631f535e30843a5a1973c9d6c5255682022-12-21T23:08:20ZengShiraz University of Medical SciencesJournal of Dentistry2345-64852345-64182021-03-01221606610.30476/DENTJODS.2020.84181.1069Comparison of Antifungal Efficacy of Zataria Multiflora and Nystatin for Treatment of Denture Stomatitis: A Randomized Clinical TrialElnaz Gonoudi 0Masoud Rezai 1Taraneh Farrokhnia 2Mehdi Goudarzi 3Alireza Sima 4Dept. of Oral Medicine, Faculty of Dentistry, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran. Dept. of Oral Medicine, Faculty of Dentistry, Tehran Medical Sciences, Islamic Azad University, Tehran, IranDept. of Oral Medicine, Faculty of Dentistry, Tehran Medical Sciences, Islamic Azad University, Tehran, IranDept. of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranDigestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.Statement of the Problem: Zataria multiflora (ZM) is a thyme-like plant that belongs to the Lamiaceae family. It is native to the center and south of Iran, Pakistan, and Afghanistan. Evidence shows that ZM contains thymol and carvacrol and is therefore, effective for the treatment of many conditions especially fungal infections. Oral candidiasis is the most common opportunistic infection of the oral mucosa that plays a role in the development of denture stomatitis. Purpose: This study aimed to compare the antifungal efficacy of ZM and nystatin suspension for the treatment of denture stomatitis. Materials and Method: This single-blind clinical trial evaluated 28 patients (> 18 years old) suffering from type II or III denture stomatitis. Patients were divided into two groups. The control group used nystatin suspension while the case group used ZM drop. The number of Candida albicans (C. albicans) colony-forming units (CFUs) and erythema of the palate were evaluated at baseline and at 14 days after treatment. Data were analyzed using SPSS version 11 via Student’s t test and repeated measure ANOVA. Results: The results showed similar efficacy of nystatin and ZM in the reduction of C.albicans CFUs compared to the baseline value (p= 0.593). Both medications significantly decreased the colony count (p< 0.001). Nystatin and ZM had similar efficacy for the reduction of erythema as well (p= 0.256) and both caused a significant reduction in erythema of the palate (p<0.001). Conclusion: ZM drop was as effective as the nystatin drop in the resolution of erythema of the palate and reduction of C. albicans colony count.https://dentjods.sums.ac.ir/article_46918.htmlcandida albicans; denture stomatitis; nystatin; zataria multiflora |
| spellingShingle | Elnaz Gonoudi Masoud Rezai Taraneh Farrokhnia Mehdi Goudarzi Alireza Sima Comparison of Antifungal Efficacy of Zataria Multiflora and Nystatin for Treatment of Denture Stomatitis: A Randomized Clinical Trial Journal of Dentistry candida albicans; denture stomatitis; nystatin; zataria multiflora |
| title | Comparison of Antifungal Efficacy of Zataria Multiflora and Nystatin for Treatment of Denture Stomatitis: A Randomized Clinical Trial |
| title_full | Comparison of Antifungal Efficacy of Zataria Multiflora and Nystatin for Treatment of Denture Stomatitis: A Randomized Clinical Trial |
| title_fullStr | Comparison of Antifungal Efficacy of Zataria Multiflora and Nystatin for Treatment of Denture Stomatitis: A Randomized Clinical Trial |
| title_full_unstemmed | Comparison of Antifungal Efficacy of Zataria Multiflora and Nystatin for Treatment of Denture Stomatitis: A Randomized Clinical Trial |
| title_short | Comparison of Antifungal Efficacy of Zataria Multiflora and Nystatin for Treatment of Denture Stomatitis: A Randomized Clinical Trial |
| title_sort | comparison of antifungal efficacy of zataria multiflora and nystatin for treatment of denture stomatitis a randomized clinical trial |
| topic | candida albicans; denture stomatitis; nystatin; zataria multiflora |
| url | https://dentjods.sums.ac.ir/article_46918.html |
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