Low-Intensity Physical Exercise Decreases Inflammation and Joint Damage in the Preclinical Phase of a Rheumatoid Arthritis Murine Model
Lifestyle modifications in preclinical Rheumatoid Arthritis (RA) could delay the ongoing pathogenic immune processes and potentially prevent its onset. Physical exercise (PE) benefits RA patients; however, its impact in reducing the risk of developing RA has scarcely been studied. The objective was...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/13/3/488 |
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| author | Susana Aideé González-Chávez Salma Marcela López-Loeza Samara Acosta-Jiménez Rubén Cuevas-Martínez César Pacheco-Silva Eduardo Chaparro-Barrera César Pacheco-Tena |
| author_facet | Susana Aideé González-Chávez Salma Marcela López-Loeza Samara Acosta-Jiménez Rubén Cuevas-Martínez César Pacheco-Silva Eduardo Chaparro-Barrera César Pacheco-Tena |
| author_sort | Susana Aideé González-Chávez |
| collection | DOAJ |
| description | Lifestyle modifications in preclinical Rheumatoid Arthritis (RA) could delay the ongoing pathogenic immune processes and potentially prevent its onset. Physical exercise (PE) benefits RA patients; however, its impact in reducing the risk of developing RA has scarcely been studied. The objective was to describe the effects of low-intensity PE applied at the disease’s preclinical phase on the joints of DBA/1 mice with collagen-induced arthritis (CIA). Twelve mice with CIA were randomly distributed into two groups: the CIA-Ex group, which undertook treadmill PE, and the CIA-NoEx, which was not exercised. The effects of PE were evaluated through clinical, histological, transcriptomics, and immunodetection analyses in the mice’s hind paws. The CIA-Ex group showed lower joint inflammation and damage and a decreased expression of RA-related genes (<i>Tnf Il2</i>, <i>Il10</i>, <i>Il12a</i>, <i>IL23a</i>, and <i>Tgfb1</i>) and signaling pathways (Cytokines, Chemokines, JAK-STAT, MAPK, NF-kappa B, TNF, and TGF-beta). TNF-α expression was decreased by PE in the inflamed joints. Low-intensity PE in pre-arthritic CIA reduced the severity through joint down-expression of proinflammatory genes and proteins. Knowledge on the underlying mechanisms of PE in preclinical arthritis and its impact on reducing the risk of developing RA is still needed. |
| first_indexed | 2024-03-11T06:52:17Z |
| format | Article |
| id | doaj.art-26324c74f13e41829f182c07fef08a0a |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-11T06:52:17Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-26324c74f13e41829f182c07fef08a0a2023-11-17T09:52:00ZengMDPI AGBiomolecules2218-273X2023-03-0113348810.3390/biom13030488Low-Intensity Physical Exercise Decreases Inflammation and Joint Damage in the Preclinical Phase of a Rheumatoid Arthritis Murine ModelSusana Aideé González-Chávez0Salma Marcela López-Loeza1Samara Acosta-Jiménez2Rubén Cuevas-Martínez3César Pacheco-Silva4Eduardo Chaparro-Barrera5César Pacheco-Tena6Laboratorio PABIOM, Facultad de Medicina y Ciencias Biomédicas, Universidad Autónoma de Chihuahua, Chihuahua 31125, MexicoLaboratorio PABIOM, Facultad de Medicina y Ciencias Biomédicas, Universidad Autónoma de Chihuahua, Chihuahua 31125, MexicoLaboratorio PABIOM, Facultad de Medicina y Ciencias Biomédicas, Universidad Autónoma de Chihuahua, Chihuahua 31125, MexicoLaboratorio PABIOM, Facultad de Medicina y Ciencias Biomédicas, Universidad Autónoma de Chihuahua, Chihuahua 31125, MexicoLaboratorio PABIOM, Facultad de Medicina y Ciencias Biomédicas, Universidad Autónoma de Chihuahua, Chihuahua 31125, MexicoLaboratorio PABIOM, Facultad de Medicina y Ciencias Biomédicas, Universidad Autónoma de Chihuahua, Chihuahua 31125, MexicoLaboratorio PABIOM, Facultad de Medicina y Ciencias Biomédicas, Universidad Autónoma de Chihuahua, Chihuahua 31125, MexicoLifestyle modifications in preclinical Rheumatoid Arthritis (RA) could delay the ongoing pathogenic immune processes and potentially prevent its onset. Physical exercise (PE) benefits RA patients; however, its impact in reducing the risk of developing RA has scarcely been studied. The objective was to describe the effects of low-intensity PE applied at the disease’s preclinical phase on the joints of DBA/1 mice with collagen-induced arthritis (CIA). Twelve mice with CIA were randomly distributed into two groups: the CIA-Ex group, which undertook treadmill PE, and the CIA-NoEx, which was not exercised. The effects of PE were evaluated through clinical, histological, transcriptomics, and immunodetection analyses in the mice’s hind paws. The CIA-Ex group showed lower joint inflammation and damage and a decreased expression of RA-related genes (<i>Tnf Il2</i>, <i>Il10</i>, <i>Il12a</i>, <i>IL23a</i>, and <i>Tgfb1</i>) and signaling pathways (Cytokines, Chemokines, JAK-STAT, MAPK, NF-kappa B, TNF, and TGF-beta). TNF-α expression was decreased by PE in the inflamed joints. Low-intensity PE in pre-arthritic CIA reduced the severity through joint down-expression of proinflammatory genes and proteins. Knowledge on the underlying mechanisms of PE in preclinical arthritis and its impact on reducing the risk of developing RA is still needed.https://www.mdpi.com/2218-273X/13/3/488physical exercisepreclinical arthritisat-risk arthritisinflammationjoint damagemicroarray |
| spellingShingle | Susana Aideé González-Chávez Salma Marcela López-Loeza Samara Acosta-Jiménez Rubén Cuevas-Martínez César Pacheco-Silva Eduardo Chaparro-Barrera César Pacheco-Tena Low-Intensity Physical Exercise Decreases Inflammation and Joint Damage in the Preclinical Phase of a Rheumatoid Arthritis Murine Model Biomolecules physical exercise preclinical arthritis at-risk arthritis inflammation joint damage microarray |
| title | Low-Intensity Physical Exercise Decreases Inflammation and Joint Damage in the Preclinical Phase of a Rheumatoid Arthritis Murine Model |
| title_full | Low-Intensity Physical Exercise Decreases Inflammation and Joint Damage in the Preclinical Phase of a Rheumatoid Arthritis Murine Model |
| title_fullStr | Low-Intensity Physical Exercise Decreases Inflammation and Joint Damage in the Preclinical Phase of a Rheumatoid Arthritis Murine Model |
| title_full_unstemmed | Low-Intensity Physical Exercise Decreases Inflammation and Joint Damage in the Preclinical Phase of a Rheumatoid Arthritis Murine Model |
| title_short | Low-Intensity Physical Exercise Decreases Inflammation and Joint Damage in the Preclinical Phase of a Rheumatoid Arthritis Murine Model |
| title_sort | low intensity physical exercise decreases inflammation and joint damage in the preclinical phase of a rheumatoid arthritis murine model |
| topic | physical exercise preclinical arthritis at-risk arthritis inflammation joint damage microarray |
| url | https://www.mdpi.com/2218-273X/13/3/488 |
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