Effects and parameters of community-based exercise on motor symptoms in Parkinson’s disease: a meta-analysis
Abstract Background Community-based exercise is a continuation and complement to inpatient rehabilitation for Parkinson's disease and does not require a professional physical therapist or equipment. The effects, parameters, and forms of each exercise are diverse, and the effect is affected by m...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-12-01
|
| Series: | BMC Neurology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12883-022-03027-z |
| _version_ | 1797973549630095360 |
|---|---|
| author | Chun-Lan Yang Jia-Peng Huang Ting-Ting Wang Ying-Chao Tan Yin Chen Zi-Qi Zhao Chao-Hua Qu Yun Qu |
| author_facet | Chun-Lan Yang Jia-Peng Huang Ting-Ting Wang Ying-Chao Tan Yin Chen Zi-Qi Zhao Chao-Hua Qu Yun Qu |
| author_sort | Chun-Lan Yang |
| collection | DOAJ |
| description | Abstract Background Community-based exercise is a continuation and complement to inpatient rehabilitation for Parkinson's disease and does not require a professional physical therapist or equipment. The effects, parameters, and forms of each exercise are diverse, and the effect is affected by many factors. A meta-analysis was conducted to determine the effect and the best parameters for improving motor symptoms and to explore the possible factors affecting the effect of community-based exercise. Methods We conducted a comprehensive search of six databases: PEDro, PubMed/Medline, CENTRAL, Scopus, Embase, and WOS. Studies that compared community-based exercise with usual care were included. The intervention mainly included dance, Chinese martial arts, Nordic walking, and home-based exercise. The primary outcome measure was the Unified Parkinson’s Disease Rating Scale part III (UPDRS-III) score. The mean difference (95% CI) was used to calculate the treatment outcomes of continuous outcome variables, and the I2 statistic was used to estimate the heterogeneity of the statistical analysis. We conducted subgroup analysis and meta-regression analysis to determine the optimal parameters and the most important influencing factors of the exercise effect. Results Twenty-two studies that enrolled a total of 809 subjects were included in the analysis. Exercise had a positive effect on the UPDRS-III (MD = -5.83; 95% CI, -8.29 to -3.37), Timed Up and Go test (MD = -2.22; 95% CI -3.02 to -1.42), UPDRS ((MD = -7.80; 95% CI -10.98 to -6.42), 6-Minute Walk Test (MD = 68.81; 95% CI, 32.14 to 105.48), and Berg Balance Scale (MD = 4.52; 95% CI, 2.72 to 5.78) scores. However, the heterogeneity of each included study was obvious. Weekly frequency, age, and duration of treatment were all factors that potentially influenced the effect. Conclusions This meta-analysis suggests that community-based exercise may benefit motor function in patients with PD. The most commonly used modalities of exercise were tango and tai chi, and the most common prescription was 60 min twice a week. Future studies should consider the influence of age, duration of treatment, and weekly frequency on the effect of exercise. PROSPERO trial registration number CRD42022327162. |
| first_indexed | 2024-04-11T04:06:02Z |
| format | Article |
| id | doaj.art-2632b5e052cb4091a8747fe60302cc18 |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-04-11T04:06:02Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-2632b5e052cb4091a8747fe60302cc182023-01-01T12:22:14ZengBMCBMC Neurology1471-23772022-12-0122111410.1186/s12883-022-03027-zEffects and parameters of community-based exercise on motor symptoms in Parkinson’s disease: a meta-analysisChun-Lan Yang0Jia-Peng Huang1Ting-Ting Wang2Ying-Chao Tan3Yin Chen4Zi-Qi Zhao5Chao-Hua Qu6Yun Qu7Department of Rehabilitation Medicine, West China Hospital, Sichuan UniversityDepartment of Rehabilitation Medicine, West China Hospital, Sichuan UniversityDepartment of Rehabilitation Medicine, West China Hospital, Sichuan UniversityEnshi Prefecture Central HospitalDepartment of Rehabilitation Medicine, West China Hospital, Sichuan UniversityDepartment of Rehabilitation Medicine, West China Hospital, Sichuan UniversityDepartment of Rehabilitation Medicine, West China Hospital, Sichuan UniversityDepartment of Rehabilitation Medicine, West China Hospital, Sichuan UniversityAbstract Background Community-based exercise is a continuation and complement to inpatient rehabilitation for Parkinson's disease and does not require a professional physical therapist or equipment. The effects, parameters, and forms of each exercise are diverse, and the effect is affected by many factors. A meta-analysis was conducted to determine the effect and the best parameters for improving motor symptoms and to explore the possible factors affecting the effect of community-based exercise. Methods We conducted a comprehensive search of six databases: PEDro, PubMed/Medline, CENTRAL, Scopus, Embase, and WOS. Studies that compared community-based exercise with usual care were included. The intervention mainly included dance, Chinese martial arts, Nordic walking, and home-based exercise. The primary outcome measure was the Unified Parkinson’s Disease Rating Scale part III (UPDRS-III) score. The mean difference (95% CI) was used to calculate the treatment outcomes of continuous outcome variables, and the I2 statistic was used to estimate the heterogeneity of the statistical analysis. We conducted subgroup analysis and meta-regression analysis to determine the optimal parameters and the most important influencing factors of the exercise effect. Results Twenty-two studies that enrolled a total of 809 subjects were included in the analysis. Exercise had a positive effect on the UPDRS-III (MD = -5.83; 95% CI, -8.29 to -3.37), Timed Up and Go test (MD = -2.22; 95% CI -3.02 to -1.42), UPDRS ((MD = -7.80; 95% CI -10.98 to -6.42), 6-Minute Walk Test (MD = 68.81; 95% CI, 32.14 to 105.48), and Berg Balance Scale (MD = 4.52; 95% CI, 2.72 to 5.78) scores. However, the heterogeneity of each included study was obvious. Weekly frequency, age, and duration of treatment were all factors that potentially influenced the effect. Conclusions This meta-analysis suggests that community-based exercise may benefit motor function in patients with PD. The most commonly used modalities of exercise were tango and tai chi, and the most common prescription was 60 min twice a week. Future studies should consider the influence of age, duration of treatment, and weekly frequency on the effect of exercise. PROSPERO trial registration number CRD42022327162.https://doi.org/10.1186/s12883-022-03027-zData synthesisExerciseMovementParkinson’s diseasePrescriptionReview |
| spellingShingle | Chun-Lan Yang Jia-Peng Huang Ting-Ting Wang Ying-Chao Tan Yin Chen Zi-Qi Zhao Chao-Hua Qu Yun Qu Effects and parameters of community-based exercise on motor symptoms in Parkinson’s disease: a meta-analysis BMC Neurology Data synthesis Exercise Movement Parkinson’s disease Prescription Review |
| title | Effects and parameters of community-based exercise on motor symptoms in Parkinson’s disease: a meta-analysis |
| title_full | Effects and parameters of community-based exercise on motor symptoms in Parkinson’s disease: a meta-analysis |
| title_fullStr | Effects and parameters of community-based exercise on motor symptoms in Parkinson’s disease: a meta-analysis |
| title_full_unstemmed | Effects and parameters of community-based exercise on motor symptoms in Parkinson’s disease: a meta-analysis |
| title_short | Effects and parameters of community-based exercise on motor symptoms in Parkinson’s disease: a meta-analysis |
| title_sort | effects and parameters of community based exercise on motor symptoms in parkinson s disease a meta analysis |
| topic | Data synthesis Exercise Movement Parkinson’s disease Prescription Review |
| url | https://doi.org/10.1186/s12883-022-03027-z |
| work_keys_str_mv | AT chunlanyang effectsandparametersofcommunitybasedexerciseonmotorsymptomsinparkinsonsdiseaseametaanalysis AT jiapenghuang effectsandparametersofcommunitybasedexerciseonmotorsymptomsinparkinsonsdiseaseametaanalysis AT tingtingwang effectsandparametersofcommunitybasedexerciseonmotorsymptomsinparkinsonsdiseaseametaanalysis AT yingchaotan effectsandparametersofcommunitybasedexerciseonmotorsymptomsinparkinsonsdiseaseametaanalysis AT yinchen effectsandparametersofcommunitybasedexerciseonmotorsymptomsinparkinsonsdiseaseametaanalysis AT ziqizhao effectsandparametersofcommunitybasedexerciseonmotorsymptomsinparkinsonsdiseaseametaanalysis AT chaohuaqu effectsandparametersofcommunitybasedexerciseonmotorsymptomsinparkinsonsdiseaseametaanalysis AT yunqu effectsandparametersofcommunitybasedexerciseonmotorsymptomsinparkinsonsdiseaseametaanalysis |