Co-Morbidities of Irritable Bowel Syndrome in a Racially and Ethnically Diverse Population
<b>Introduction</b>: Irritable bowel syndrome (IBS) is a disorder of gut–brain interaction (DGBI), and associated co-morbidities worsen quality of life. Research concerning IBS co-morbidities in different racial/ethnic groups is very sparse. This study aimed to determine the prevalence r...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-03-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/13/5/1482 |
| _version_ | 1797264278889168896 |
|---|---|
| author | Christina Lee Supriya Rao Howard J. Cabral Horst Christian Weber |
| author_facet | Christina Lee Supriya Rao Howard J. Cabral Horst Christian Weber |
| author_sort | Christina Lee |
| collection | DOAJ |
| description | <b>Introduction</b>: Irritable bowel syndrome (IBS) is a disorder of gut–brain interaction (DGBI), and associated co-morbidities worsen quality of life. Research concerning IBS co-morbidities in different racial/ethnic groups is very sparse. This study aimed to determine the prevalence rates of co-morbidities and possible differences in a multiracial/ethnic IBS cohort. <b>Methods</b>: Based on ICD-9-coded IBS diagnosis, 740 outpatients (≥18 years) were included in this retrospective study at Boston Medical Center. Demographics and ICD-9-coded co-morbidities were extracted from electronic records. Descriptive statistics and multiple logistic regression were used for data analyses. <b>Results</b>: The most prevalent co-morbidities in this IBS cohort included gastroesophageal reflux disorder (GERD) (30%), depression (27%), anxiety (23%), (chronic obstructive pulmonary disease) COPD/asthma (16%), and obesity (10%). GERD was more prevalent in Hispanics and Blacks (<i>p</i> = 0.0005), and non-ulcer dyspepsia (NUD) was more prevalent in Blacks and Asians (<i>p</i> = 0.003). Higher rates of diabetes mellitus type 2 (DMT2) (<i>p</i> = 0.0003) and depression (<i>p</i> = 0.03), but not anxiety (<i>p</i> = 0.9), were present in Blacks and Hispanics. GERD was significantly associated with Hispanics (<i>p</i> = 0.003), dependent on age, overweight, and obesity. NUD was significantly associated with Blacks (<i>p</i> = 0.01) and Asians (<i>p</i> = 0.006), independent of sex, age, and BMI. Cancer of the thyroid, ovaries, and testis occurred at a five-fold higher rate than expected. <b>Conclusions</b>: Significant racial/ethnic differences exist for IBS co-morbidities in this study cohort, including depression, DMT2, GERD, and NUD. Certain cancers were found to be more frequent in this IBS sample as compared with the general population. |
| first_indexed | 2024-04-25T00:26:22Z |
| format | Article |
| id | doaj.art-2635201019ee45f0a8361b8760e3c33e |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-04-25T00:26:22Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-2635201019ee45f0a8361b8760e3c33e2024-03-12T16:48:37ZengMDPI AGJournal of Clinical Medicine2077-03832024-03-01135148210.3390/jcm13051482Co-Morbidities of Irritable Bowel Syndrome in a Racially and Ethnically Diverse PopulationChristina Lee0Supriya Rao1Howard J. Cabral2Horst Christian Weber3Hospital Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USAIntegrated Gastroenterology Consultants, Lawrence, MA 01841, USADepartment of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USASection of Gastroenterology & Hepatology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA<b>Introduction</b>: Irritable bowel syndrome (IBS) is a disorder of gut–brain interaction (DGBI), and associated co-morbidities worsen quality of life. Research concerning IBS co-morbidities in different racial/ethnic groups is very sparse. This study aimed to determine the prevalence rates of co-morbidities and possible differences in a multiracial/ethnic IBS cohort. <b>Methods</b>: Based on ICD-9-coded IBS diagnosis, 740 outpatients (≥18 years) were included in this retrospective study at Boston Medical Center. Demographics and ICD-9-coded co-morbidities were extracted from electronic records. Descriptive statistics and multiple logistic regression were used for data analyses. <b>Results</b>: The most prevalent co-morbidities in this IBS cohort included gastroesophageal reflux disorder (GERD) (30%), depression (27%), anxiety (23%), (chronic obstructive pulmonary disease) COPD/asthma (16%), and obesity (10%). GERD was more prevalent in Hispanics and Blacks (<i>p</i> = 0.0005), and non-ulcer dyspepsia (NUD) was more prevalent in Blacks and Asians (<i>p</i> = 0.003). Higher rates of diabetes mellitus type 2 (DMT2) (<i>p</i> = 0.0003) and depression (<i>p</i> = 0.03), but not anxiety (<i>p</i> = 0.9), were present in Blacks and Hispanics. GERD was significantly associated with Hispanics (<i>p</i> = 0.003), dependent on age, overweight, and obesity. NUD was significantly associated with Blacks (<i>p</i> = 0.01) and Asians (<i>p</i> = 0.006), independent of sex, age, and BMI. Cancer of the thyroid, ovaries, and testis occurred at a five-fold higher rate than expected. <b>Conclusions</b>: Significant racial/ethnic differences exist for IBS co-morbidities in this study cohort, including depression, DMT2, GERD, and NUD. Certain cancers were found to be more frequent in this IBS sample as compared with the general population.https://www.mdpi.com/2077-0383/13/5/1482irritable bowel syndromeepidemiologyracial and ethnic diversityco-morbiditiescancer |
| spellingShingle | Christina Lee Supriya Rao Howard J. Cabral Horst Christian Weber Co-Morbidities of Irritable Bowel Syndrome in a Racially and Ethnically Diverse Population Journal of Clinical Medicine irritable bowel syndrome epidemiology racial and ethnic diversity co-morbidities cancer |
| title | Co-Morbidities of Irritable Bowel Syndrome in a Racially and Ethnically Diverse Population |
| title_full | Co-Morbidities of Irritable Bowel Syndrome in a Racially and Ethnically Diverse Population |
| title_fullStr | Co-Morbidities of Irritable Bowel Syndrome in a Racially and Ethnically Diverse Population |
| title_full_unstemmed | Co-Morbidities of Irritable Bowel Syndrome in a Racially and Ethnically Diverse Population |
| title_short | Co-Morbidities of Irritable Bowel Syndrome in a Racially and Ethnically Diverse Population |
| title_sort | co morbidities of irritable bowel syndrome in a racially and ethnically diverse population |
| topic | irritable bowel syndrome epidemiology racial and ethnic diversity co-morbidities cancer |
| url | https://www.mdpi.com/2077-0383/13/5/1482 |
| work_keys_str_mv | AT christinalee comorbiditiesofirritablebowelsyndromeinaraciallyandethnicallydiversepopulation AT supriyarao comorbiditiesofirritablebowelsyndromeinaraciallyandethnicallydiversepopulation AT howardjcabral comorbiditiesofirritablebowelsyndromeinaraciallyandethnicallydiversepopulation AT horstchristianweber comorbiditiesofirritablebowelsyndromeinaraciallyandethnicallydiversepopulation |