Serum Biomarkers for the Diagnosis of Glaucoma
Despite the importance of the early detection of glaucoma, most patients with progressive glaucoma show minimal symptoms. We aimed to evaluate biomarkers for glaucoma diagnosis in Korea. Forty-two volunteers with/without open-angle glaucoma were enrolled from January through October 2015—divided int...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-12-01
|
| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/11/1/20 |
| _version_ | 1797543619585900544 |
|---|---|
| author | Young Joo Shin Eunbi Kim Bobby Kwanghoon Han Kayoung Yi |
| author_facet | Young Joo Shin Eunbi Kim Bobby Kwanghoon Han Kayoung Yi |
| author_sort | Young Joo Shin |
| collection | DOAJ |
| description | Despite the importance of the early detection of glaucoma, most patients with progressive glaucoma show minimal symptoms. We aimed to evaluate biomarkers for glaucoma diagnosis in Korea. Forty-two volunteers with/without open-angle glaucoma were enrolled from January through October 2015—divided into a control or open-angle glaucoma group, which was further divided into normal-tension glaucoma (NTG) and high-tension glaucoma (HTG) groups—and underwent assessments for myelin basic protein (MBP), heat shock protein 60, anti-Sjögren’s-syndrome-related antigen A (SSA) and antigen B (SSB), anti-α-fodrin, and anti-nucleic acid. The glaucoma group showed a higher serum MBP level and lower serum anti-α-fodrin antibody level than the control group (<i>p</i> < 0.05). The NTG group showed higher serum anti-SSA and anti-SSB levels and lower anti-α-fodrin IgG/IgA levels than the HTG group. In the receiver operating characteristic curve analysis, the area under the curve (AUC) for serum MBP level was 0.917 in discriminating between controls and patients with glaucoma. Between the NTG and HTG groups, anti-SSA, anti-SSB, and anti-α-fodrin IgG/IgA levels showed an AUC above 0.8. Thus, these biomarkers were useful for diagnosing glaucoma and discriminating between controls and patients with glaucoma, and patients with NTG and HTG. |
| first_indexed | 2024-03-10T13:47:12Z |
| format | Article |
| id | doaj.art-26363ee4c3404228a84a7d0ec1c3f814 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T13:47:12Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-26363ee4c3404228a84a7d0ec1c3f8142023-11-21T02:26:43ZengMDPI AGDiagnostics2075-44182020-12-011112010.3390/diagnostics11010020Serum Biomarkers for the Diagnosis of GlaucomaYoung Joo Shin0Eunbi Kim1Bobby Kwanghoon Han2Kayoung Yi3Department of Ophthalmology, Hallym University College of Medicine, Seoul 07441, KoreaDepartment of Ophthalmology, Hallym University College of Medicine, Seoul 07441, KoreaDivision of Rheumatology, University of Washington, Seattle, WA 98195, USADepartment of Ophthalmology, Hallym University College of Medicine, Seoul 07441, KoreaDespite the importance of the early detection of glaucoma, most patients with progressive glaucoma show minimal symptoms. We aimed to evaluate biomarkers for glaucoma diagnosis in Korea. Forty-two volunteers with/without open-angle glaucoma were enrolled from January through October 2015—divided into a control or open-angle glaucoma group, which was further divided into normal-tension glaucoma (NTG) and high-tension glaucoma (HTG) groups—and underwent assessments for myelin basic protein (MBP), heat shock protein 60, anti-Sjögren’s-syndrome-related antigen A (SSA) and antigen B (SSB), anti-α-fodrin, and anti-nucleic acid. The glaucoma group showed a higher serum MBP level and lower serum anti-α-fodrin antibody level than the control group (<i>p</i> < 0.05). The NTG group showed higher serum anti-SSA and anti-SSB levels and lower anti-α-fodrin IgG/IgA levels than the HTG group. In the receiver operating characteristic curve analysis, the area under the curve (AUC) for serum MBP level was 0.917 in discriminating between controls and patients with glaucoma. Between the NTG and HTG groups, anti-SSA, anti-SSB, and anti-α-fodrin IgG/IgA levels showed an AUC above 0.8. Thus, these biomarkers were useful for diagnosing glaucoma and discriminating between controls and patients with glaucoma, and patients with NTG and HTG.https://www.mdpi.com/2075-4418/11/1/20normal-tension glaucomaprimary open-angle glaucomaglaucomabiomarkerautoantibody |
| spellingShingle | Young Joo Shin Eunbi Kim Bobby Kwanghoon Han Kayoung Yi Serum Biomarkers for the Diagnosis of Glaucoma Diagnostics normal-tension glaucoma primary open-angle glaucoma glaucoma biomarker autoantibody |
| title | Serum Biomarkers for the Diagnosis of Glaucoma |
| title_full | Serum Biomarkers for the Diagnosis of Glaucoma |
| title_fullStr | Serum Biomarkers for the Diagnosis of Glaucoma |
| title_full_unstemmed | Serum Biomarkers for the Diagnosis of Glaucoma |
| title_short | Serum Biomarkers for the Diagnosis of Glaucoma |
| title_sort | serum biomarkers for the diagnosis of glaucoma |
| topic | normal-tension glaucoma primary open-angle glaucoma glaucoma biomarker autoantibody |
| url | https://www.mdpi.com/2075-4418/11/1/20 |
| work_keys_str_mv | AT youngjooshin serumbiomarkersforthediagnosisofglaucoma AT eunbikim serumbiomarkersforthediagnosisofglaucoma AT bobbykwanghoonhan serumbiomarkersforthediagnosisofglaucoma AT kayoungyi serumbiomarkersforthediagnosisofglaucoma |