Inclisiran inhibits oxidized low-density lipoprotein-induced foam cell formation in Raw264.7 macrophages via activating the PPARγ pathway

Inclisiran inhibits oxidized low-density lipoprotein-induced foam cell formation in Raw264.7 macrophages via activating the PPARγ pathway

Proprotein convertase subtilisin kexin type 9 (PCSK9) is a well-known proprotein convertase that influences foam cell formation and modulates atherosclerosis. Inclisiran is a novel chemosynthetic small interfering RNA that inhibits PCSK9 synthesis. This study aimed to explore the effect of inclisira...

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Bibliographic Details
Main Authors: Zhaoping Wang, Xiangyu Chen, Jingxing Liu, Yingcui Wang, Suhua Zhang
Format: Article
Language:English
Published: Taylor & Francis Group 2022-05-01
Series:Autoimmunity
Subjects:
atherosclerosis
inclisiran
lipid accumulation
foam cell
pparγ
Online Access:http://dx.doi.org/10.1080/08916934.2022.2051142

Internet

http://dx.doi.org/10.1080/08916934.2022.2051142

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