Germline amino acid diversity in B cell receptors is a good predictor of somatic selection pressures.
The diversity of the immune repertoire is important for the adaptive immunesystem's ability to detect pathogens. Much of this diversity is generated in twosteps, first through the recombination of germline gene segments and secondthrough hypermutation during an immune response. While both st...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2013-11-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00357/full |