Clinicopathologic Features and Prognostic Implications in 72 Cases with Lung Adenosquamous Carcinoma
Background and objective Adenosquamous carcinoma (ASC) is a rare subtype of lung cancer, it is mixed glandular and squamous cell carcinoma with a more aggressive behavior and poor prognosis than the other histologic subtypes. The aim of the study was to explore the clinicopathological characteristic...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | zho |
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Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2016-10-01
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| Series: | Chinese Journal of Lung Cancer |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.3779/j.issn.1009-3419.2016.10.03 |
| _version_ | 1819277963429937152 |
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| author | Xi WU Junling LI Shulan CHEN Lei YU Boyan YANG |
| author_facet | Xi WU Junling LI Shulan CHEN Lei YU Boyan YANG |
| author_sort | Xi WU |
| collection | DOAJ |
| description | Background and objective Adenosquamous carcinoma (ASC) is a rare subtype of lung cancer, it is mixed glandular and squamous cell carcinoma with a more aggressive behavior and poor prognosis than the other histologic subtypes. The aim of the study was to explore the clinicopathological characteristics and prognostic factors of ASC. Methods A total of 72 patients were enrolled. We investigated clinicalpathological features and prognostic factors retrospectively. Results The overall 72 ASC patients’ median age was 34.7 months, 5-year survival rate was 14.9%. The influence of tumor size, M stage, and N stage, gene mutation and surgery on the prognosis of patients show statistical significance. Conclusion ASC is characterized by both histologic aggressiveness and adverse prognosis. We suggest the comprehensive therapy based on surgery, and given small molecule tyrosine kinase inhibitors (TKIs) treatment may prolong patients’ overall survival. |
| first_indexed | 2024-12-24T00:04:28Z |
| format | Article |
| id | doaj.art-263a55f48fb84ae4af7ed3d18288bf13 |
| institution | Directory Open Access Journal |
| issn | 1009-3419 1999-6187 |
| language | zho |
| last_indexed | 2024-12-24T00:04:28Z |
| publishDate | 2016-10-01 |
| publisher | Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
| record_format | Article |
| series | Chinese Journal of Lung Cancer |
| spelling | doaj.art-263a55f48fb84ae4af7ed3d18288bf132022-12-21T17:25:02ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872016-10-011910pagepage10.3779/j.issn.1009-3419.2016.10.03Clinicopathologic Features and Prognostic Implications in 72 Cases
with Lung Adenosquamous CarcinomaXi WU0Junling LI1Shulan CHEN2Lei YU3Boyan YANG4General DepartmentInternal DepartmentMedical Record Department, National Cancer Center/Cancer Hospital Chinese
Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, ChinaGeneral DepartmentGeneral DepartmentBackground and objective Adenosquamous carcinoma (ASC) is a rare subtype of lung cancer, it is mixed glandular and squamous cell carcinoma with a more aggressive behavior and poor prognosis than the other histologic subtypes. The aim of the study was to explore the clinicopathological characteristics and prognostic factors of ASC. Methods A total of 72 patients were enrolled. We investigated clinicalpathological features and prognostic factors retrospectively. Results The overall 72 ASC patients’ median age was 34.7 months, 5-year survival rate was 14.9%. The influence of tumor size, M stage, and N stage, gene mutation and surgery on the prognosis of patients show statistical significance. Conclusion ASC is characterized by both histologic aggressiveness and adverse prognosis. We suggest the comprehensive therapy based on surgery, and given small molecule tyrosine kinase inhibitors (TKIs) treatment may prolong patients’ overall survival.http://dx.doi.org/10.3779/j.issn.1009-3419.2016.10.03Lung neoplasmsAdenosquamous carcinomaClinicopathologyPrognosis |
| spellingShingle | Xi WU Junling LI Shulan CHEN Lei YU Boyan YANG Clinicopathologic Features and Prognostic Implications in 72 Cases with Lung Adenosquamous Carcinoma Chinese Journal of Lung Cancer Lung neoplasms Adenosquamous carcinoma Clinicopathology Prognosis |
| title | Clinicopathologic Features and Prognostic Implications in 72 Cases
with Lung Adenosquamous Carcinoma |
| title_full | Clinicopathologic Features and Prognostic Implications in 72 Cases
with Lung Adenosquamous Carcinoma |
| title_fullStr | Clinicopathologic Features and Prognostic Implications in 72 Cases
with Lung Adenosquamous Carcinoma |
| title_full_unstemmed | Clinicopathologic Features and Prognostic Implications in 72 Cases
with Lung Adenosquamous Carcinoma |
| title_short | Clinicopathologic Features and Prognostic Implications in 72 Cases
with Lung Adenosquamous Carcinoma |
| title_sort | clinicopathologic features and prognostic implications in 72 cases
with lung adenosquamous carcinoma |
| topic | Lung neoplasms Adenosquamous carcinoma Clinicopathology Prognosis |
| url | http://dx.doi.org/10.3779/j.issn.1009-3419.2016.10.03 |
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