Iron Oxide Nanoparticles in Regenerative Medicine and Tissue Engineering
In recent years, many promising nanotechnological approaches to biomedical research have been developed in order to increase implementation of regenerative medicine and tissue engineering in clinical practice. In the meantime, the use of nanomaterials for the regeneration of diseased or injured tiss...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/11/9/2337 |
| _version_ | 1797517850495156224 |
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| author | Ralf P. Friedrich Iwona Cicha Christoph Alexiou |
| author_facet | Ralf P. Friedrich Iwona Cicha Christoph Alexiou |
| author_sort | Ralf P. Friedrich |
| collection | DOAJ |
| description | In recent years, many promising nanotechnological approaches to biomedical research have been developed in order to increase implementation of regenerative medicine and tissue engineering in clinical practice. In the meantime, the use of nanomaterials for the regeneration of diseased or injured tissues is considered advantageous in most areas of medicine. In particular, for the treatment of cardiovascular, osteochondral and neurological defects, but also for the recovery of functions of other organs such as kidney, liver, pancreas, bladder, urethra and for wound healing, nanomaterials are increasingly being developed that serve as scaffolds, mimic the extracellular matrix and promote adhesion or differentiation of cells. This review focuses on the latest developments in regenerative medicine, in which iron oxide nanoparticles (IONPs) play a crucial role for tissue engineering and cell therapy. IONPs are not only enabling the use of non-invasive observation methods to monitor the therapy, but can also accelerate and enhance regeneration, either thanks to their inherent magnetic properties or by functionalization with bioactive or therapeutic compounds, such as drugs, enzymes and growth factors. In addition, the presence of magnetic fields can direct IONP-labeled cells specifically to the site of action or induce cell differentiation into a specific cell type through mechanotransduction. |
| first_indexed | 2024-03-10T07:21:56Z |
| format | Article |
| id | doaj.art-263bf868047e4e6a8d21ad606e85e9b2 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T07:21:56Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-263bf868047e4e6a8d21ad606e85e9b22023-11-22T14:30:58ZengMDPI AGNanomaterials2079-49912021-09-01119233710.3390/nano11092337Iron Oxide Nanoparticles in Regenerative Medicine and Tissue EngineeringRalf P. Friedrich0Iwona Cicha1Christoph Alexiou2Department of Otorhinolaryngology, Head and Neck Surgery, Section of Experimental Oncology and Nanomedicine (SEON), Else Kröner-Fresenius-Stiftung Professorship, Universitätsklinikum Erlangen, 91054 Erlangen, GermanyDepartment of Otorhinolaryngology, Head and Neck Surgery, Section of Experimental Oncology and Nanomedicine (SEON), Else Kröner-Fresenius-Stiftung Professorship, Universitätsklinikum Erlangen, 91054 Erlangen, GermanyDepartment of Otorhinolaryngology, Head and Neck Surgery, Section of Experimental Oncology and Nanomedicine (SEON), Else Kröner-Fresenius-Stiftung Professorship, Universitätsklinikum Erlangen, 91054 Erlangen, GermanyIn recent years, many promising nanotechnological approaches to biomedical research have been developed in order to increase implementation of regenerative medicine and tissue engineering in clinical practice. In the meantime, the use of nanomaterials for the regeneration of diseased or injured tissues is considered advantageous in most areas of medicine. In particular, for the treatment of cardiovascular, osteochondral and neurological defects, but also for the recovery of functions of other organs such as kidney, liver, pancreas, bladder, urethra and for wound healing, nanomaterials are increasingly being developed that serve as scaffolds, mimic the extracellular matrix and promote adhesion or differentiation of cells. This review focuses on the latest developments in regenerative medicine, in which iron oxide nanoparticles (IONPs) play a crucial role for tissue engineering and cell therapy. IONPs are not only enabling the use of non-invasive observation methods to monitor the therapy, but can also accelerate and enhance regeneration, either thanks to their inherent magnetic properties or by functionalization with bioactive or therapeutic compounds, such as drugs, enzymes and growth factors. In addition, the presence of magnetic fields can direct IONP-labeled cells specifically to the site of action or induce cell differentiation into a specific cell type through mechanotransduction.https://www.mdpi.com/2079-4991/11/9/2337superparamagnetic iron oxide nanoparticlesSPIONmagnetic drug deliverymagnetic resonance imagingmagnetic particlesnanomedicine |
| spellingShingle | Ralf P. Friedrich Iwona Cicha Christoph Alexiou Iron Oxide Nanoparticles in Regenerative Medicine and Tissue Engineering Nanomaterials superparamagnetic iron oxide nanoparticles SPION magnetic drug delivery magnetic resonance imaging magnetic particles nanomedicine |
| title | Iron Oxide Nanoparticles in Regenerative Medicine and Tissue Engineering |
| title_full | Iron Oxide Nanoparticles in Regenerative Medicine and Tissue Engineering |
| title_fullStr | Iron Oxide Nanoparticles in Regenerative Medicine and Tissue Engineering |
| title_full_unstemmed | Iron Oxide Nanoparticles in Regenerative Medicine and Tissue Engineering |
| title_short | Iron Oxide Nanoparticles in Regenerative Medicine and Tissue Engineering |
| title_sort | iron oxide nanoparticles in regenerative medicine and tissue engineering |
| topic | superparamagnetic iron oxide nanoparticles SPION magnetic drug delivery magnetic resonance imaging magnetic particles nanomedicine |
| url | https://www.mdpi.com/2079-4991/11/9/2337 |
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