Lipid accumulation product index in HIV-infected patients: a marker of cardiovascular risk
ABSTRACT The lipid accumulation product (LAP) index is an emerging cardiovascular risk marker. We aimed to assess the accuracy of this index as a marker of cardiovascular risk in HIV-infected patients. A cross-sectional study of 133 HIV-infected patients on antiretroviral drugs and 20 non-infected c...
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| Format: | Article |
| Language: | English |
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Elsevier
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| Series: | Brazilian Journal of Infectious Diseases |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000300171&lng=en&tlng=en |
| _version_ | 1819112161253785600 |
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| author | Milena Maria Moreira Guimarães Dirceu Bartolomeu Greco Allyson Nogueira Moreira Nathalia Sernizon Guimarães Cláudia Maria Vilas Freire Bruna Guimarães Rohlfs Lucas José de Campos Machado |
| author_facet | Milena Maria Moreira Guimarães Dirceu Bartolomeu Greco Allyson Nogueira Moreira Nathalia Sernizon Guimarães Cláudia Maria Vilas Freire Bruna Guimarães Rohlfs Lucas José de Campos Machado |
| author_sort | Milena Maria Moreira Guimarães |
| collection | DOAJ |
| description | ABSTRACT The lipid accumulation product (LAP) index is an emerging cardiovascular risk marker. We aimed to assess the accuracy of this index as a marker of cardiovascular risk in HIV-infected patients. A cross-sectional study of 133 HIV-infected patients on antiretroviral drugs and 20 non-infected controls was conducted at the outpatient clinic of a referral center of infectious and parasitic diseases. Evaluations included LAP index, homeostasis model assessment (HOMA) index, anthropometric measurements, blood pressure, glucose tolerance test, and cholesterol and triglyceride levels. Body mass index (BMI) was similar in both groups; however, waist circumference was greater in the HIV-infected patients. Triglyceride levels were significantly higher (p < 0.001) and HDL cholesterol levels were lower in HIV-infected patients (p < 0.001). Plasma glucose (p = 0.01) and insulin (p = 0.005) levels two hours after a glucose load, HOMA-IR index (p < 0.001) and LAP index (p < 0.001) were higher in the HIV-infected patients. A positive and significant correlation was found between HOMA-IR index and LAP (r = 0.615; p < 0.01), BMI (r = 0.334; p < 0.01) and waist circumference (r = 0.452; p < 0.01) in the HIV-infected patients. In male HIV-infected patients and controls, ROC curve analyses revealed that the best cut-off value of LAP to define the presence of insulin resistance was 64.8 (sensitivity 86%, specificity 77% and area under the curve 0.824). These results confirm that insulin resistance is more common in HIV-patients on antiretroviral drugs than in HIV-negative controls. A positive and significant correlation was found between the LAP index and the HOMA index, with LAP ≥ 64.8 constituting an additional risk factor for cardiovascular disease in male HIV patients. |
| first_indexed | 2024-12-22T04:09:06Z |
| format | Article |
| id | doaj.art-263c4c3ab2434220a8aac0a6fff1e847 |
| institution | Directory Open Access Journal |
| issn | 1678-4391 |
| language | English |
| last_indexed | 2024-12-22T04:09:06Z |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-263c4c3ab2434220a8aac0a6fff1e8472022-12-21T18:39:33ZengElsevierBrazilian Journal of Infectious Diseases1678-439122317117610.1016/j.bjid.2018.03.006S1413-86702018000300171Lipid accumulation product index in HIV-infected patients: a marker of cardiovascular riskMilena Maria Moreira GuimarãesDirceu Bartolomeu GrecoAllyson Nogueira MoreiraNathalia Sernizon GuimarãesCláudia Maria Vilas FreireBruna Guimarães RohlfsLucas José de Campos MachadoABSTRACT The lipid accumulation product (LAP) index is an emerging cardiovascular risk marker. We aimed to assess the accuracy of this index as a marker of cardiovascular risk in HIV-infected patients. A cross-sectional study of 133 HIV-infected patients on antiretroviral drugs and 20 non-infected controls was conducted at the outpatient clinic of a referral center of infectious and parasitic diseases. Evaluations included LAP index, homeostasis model assessment (HOMA) index, anthropometric measurements, blood pressure, glucose tolerance test, and cholesterol and triglyceride levels. Body mass index (BMI) was similar in both groups; however, waist circumference was greater in the HIV-infected patients. Triglyceride levels were significantly higher (p < 0.001) and HDL cholesterol levels were lower in HIV-infected patients (p < 0.001). Plasma glucose (p = 0.01) and insulin (p = 0.005) levels two hours after a glucose load, HOMA-IR index (p < 0.001) and LAP index (p < 0.001) were higher in the HIV-infected patients. A positive and significant correlation was found between HOMA-IR index and LAP (r = 0.615; p < 0.01), BMI (r = 0.334; p < 0.01) and waist circumference (r = 0.452; p < 0.01) in the HIV-infected patients. In male HIV-infected patients and controls, ROC curve analyses revealed that the best cut-off value of LAP to define the presence of insulin resistance was 64.8 (sensitivity 86%, specificity 77% and area under the curve 0.824). These results confirm that insulin resistance is more common in HIV-patients on antiretroviral drugs than in HIV-negative controls. A positive and significant correlation was found between the LAP index and the HOMA index, with LAP ≥ 64.8 constituting an additional risk factor for cardiovascular disease in male HIV patients.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000300171&lng=en&tlng=enHIVHyperlipidemiaAtherosclerosisLipid accumulation product indexCardiovascular riskInsulin resistance |
| spellingShingle | Milena Maria Moreira Guimarães Dirceu Bartolomeu Greco Allyson Nogueira Moreira Nathalia Sernizon Guimarães Cláudia Maria Vilas Freire Bruna Guimarães Rohlfs Lucas José de Campos Machado Lipid accumulation product index in HIV-infected patients: a marker of cardiovascular risk Brazilian Journal of Infectious Diseases HIV Hyperlipidemia Atherosclerosis Lipid accumulation product index Cardiovascular risk Insulin resistance |
| title | Lipid accumulation product index in HIV-infected patients: a marker of cardiovascular risk |
| title_full | Lipid accumulation product index in HIV-infected patients: a marker of cardiovascular risk |
| title_fullStr | Lipid accumulation product index in HIV-infected patients: a marker of cardiovascular risk |
| title_full_unstemmed | Lipid accumulation product index in HIV-infected patients: a marker of cardiovascular risk |
| title_short | Lipid accumulation product index in HIV-infected patients: a marker of cardiovascular risk |
| title_sort | lipid accumulation product index in hiv infected patients a marker of cardiovascular risk |
| topic | HIV Hyperlipidemia Atherosclerosis Lipid accumulation product index Cardiovascular risk Insulin resistance |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000300171&lng=en&tlng=en |
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