Effects of cancer type and sex on genetic testing for clinician recommendation and uptake
This study investigated reasons for lower-than-expected uptake of germline genetic testing compared to national guidelines amongst adult patients with cancer, self-reporting clinician recommendation for genetic testing. Cross-sectional survey of 596 patients with a personal history of cancer, res...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MRE Press
2023-12-01
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| Series: | Journal of Men's Health |
| Subjects: | |
| Online Access: | https://oss.jomh.org/files/article/20231229-160/pdf/JOMH2023070401.pdf |
| Summary: | This study investigated reasons for lower-than-expected uptake of germline
genetic testing compared to national guidelines amongst adult patients with
cancer, self-reporting clinician recommendation for genetic testing. Cross-sectional survey of 596 patients with a personal history of cancer,
responded about their cancer diagnosis, physician recommendation for and status
of genetic testing and demographics. Adjusting for potential confounding
factors (cancer type, education, income and insurance status) male sex
significantly decreased odds of receiving a clinical recommendation for genetic
testing (Odds Ratio: 0.06; 95% Confidence Interval: 0.04–0.10). Females, with a
diagnosis of breast cancer, were more likely to receive a recommendation than
other cancer types (64.8% vs. 90.9%, p < 0.001).
Participants who received a physician recommendation were significantly more
likely to receive genetic testing (p < 0.001). Clinician
recommendation is an important driver of genetic testing, necessitating efforts
to increase clinician recommendations, particularly for males and patients with
cancers other than breast. |
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| ISSN: | 1875-6867 1875-6859 |