Topical Effects of Glycirrhizic Acid on Allergic Rhinitis in Comparison to the Beclomethazone Treatment
Background: Drug treatment of Allergic rhinitis is based on anti-histaminic and antiinflammatory drugs. Glycyrrhizic acid is an effective ingredient of liquorice root that has affirmed anti-histaminic and anti-inflammatory natures. Objective: The present study has evaluated the clinical efficacy of...
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| Format: | Article |
| Language: | English |
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Institue of Medicinal Plants, ACECR
2012-11-01
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| Series: | Journal of Medicinal Plants |
| Subjects: | |
| Online Access: | http://jmp.ir/article-1-125-en.html |
| _version_ | 1818725947295137792 |
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| author | A Akhavan M Saberi F Saberi |
| author_facet | A Akhavan M Saberi F Saberi |
| author_sort | A Akhavan |
| collection | DOAJ |
| description | Background: Drug treatment of Allergic rhinitis is based on anti-histaminic and antiinflammatory drugs. Glycyrrhizic acid is an effective ingredient of liquorice root that has affirmed anti-histaminic and anti-inflammatory natures. Objective: The present study has evaluated the clinical efficacy of local glycyrrhizinic acid drop for treatment or reduction of allergic rhinitis. Methods: A double blind clinical trial study was preceded on patients with allergic rhinitis that referred to the ENT clinic of Baghiyatallah hospital. The severity of rhinitis symptoms (rhino rhea, Sneeze, pruritus, congestion) were evaluated before and after treatment with either beclomethasone nasal spray (standard) or glycirrhizic acib nasal drop. Also, complications of treatments and rate of recovery were recorded. Results: The rate of allergic rhinitis symptoms including, sever rhinorhea, Sneeze, pruritus and congestion were lowered significantly after consuming of either glycyrrhicinc acid or beclomethasone nasal spray on day 3. While, more reduction of moderate sneeze and congestion was seen prominently in patients who received beclomethasone, but patients with mild symptoms were increased in beclomethasone treated group. Conclusion: This study showed that efficacy of glycyrrhizinc acid nasal drop is closely similar and comparable to the beclomethasone nasal spray in treatment of severe symptoms of allergic rhinitis. So, this drug can be premier for treatment of severe allergic rhinitis, because of more accessibility and less complications than chemical drugs. |
| first_indexed | 2024-12-17T21:50:24Z |
| format | Article |
| id | doaj.art-263f39c49ce1414da160a5e48929887b |
| institution | Directory Open Access Journal |
| issn | 2717-204X 2717-2058 |
| language | English |
| last_indexed | 2024-12-17T21:50:24Z |
| publishDate | 2012-11-01 |
| publisher | Institue of Medicinal Plants, ACECR |
| record_format | Article |
| series | Journal of Medicinal Plants |
| spelling | doaj.art-263f39c49ce1414da160a5e48929887b2022-12-21T21:31:20ZengInstitue of Medicinal Plants, ACECRJournal of Medicinal Plants2717-204X2717-20582012-11-011144120129Topical Effects of Glycirrhizic Acid on Allergic Rhinitis in Comparison to the Beclomethazone TreatmentA Akhavan0M Saberi1F Saberi2 Department of ENT, Baqiyatallah University of Medical Sciences Depatment of Pharmacology and Toxicology, Applied Neuroscience Research Center, Faculty of Medicine, Baqiyatallah University of Medical Sciences Depatment of Pharmacology and Toxicology, Applied Neuroscience Research Center, Faculty of Medicine, Baqiyatallah University of Medical Sciences Background: Drug treatment of Allergic rhinitis is based on anti-histaminic and antiinflammatory drugs. Glycyrrhizic acid is an effective ingredient of liquorice root that has affirmed anti-histaminic and anti-inflammatory natures. Objective: The present study has evaluated the clinical efficacy of local glycyrrhizinic acid drop for treatment or reduction of allergic rhinitis. Methods: A double blind clinical trial study was preceded on patients with allergic rhinitis that referred to the ENT clinic of Baghiyatallah hospital. The severity of rhinitis symptoms (rhino rhea, Sneeze, pruritus, congestion) were evaluated before and after treatment with either beclomethasone nasal spray (standard) or glycirrhizic acib nasal drop. Also, complications of treatments and rate of recovery were recorded. Results: The rate of allergic rhinitis symptoms including, sever rhinorhea, Sneeze, pruritus and congestion were lowered significantly after consuming of either glycyrrhicinc acid or beclomethasone nasal spray on day 3. While, more reduction of moderate sneeze and congestion was seen prominently in patients who received beclomethasone, but patients with mild symptoms were increased in beclomethasone treated group. Conclusion: This study showed that efficacy of glycyrrhizinc acid nasal drop is closely similar and comparable to the beclomethasone nasal spray in treatment of severe symptoms of allergic rhinitis. So, this drug can be premier for treatment of severe allergic rhinitis, because of more accessibility and less complications than chemical drugs.http://jmp.ir/article-1-125-en.htmlallergyallergic rhinitisglycyrrhizinic acidbeclomethasone |
| spellingShingle | A Akhavan M Saberi F Saberi Topical Effects of Glycirrhizic Acid on Allergic Rhinitis in Comparison to the Beclomethazone Treatment Journal of Medicinal Plants allergy allergic rhinitis glycyrrhizinic acid beclomethasone |
| title | Topical Effects of Glycirrhizic Acid on Allergic Rhinitis in Comparison to the Beclomethazone Treatment |
| title_full | Topical Effects of Glycirrhizic Acid on Allergic Rhinitis in Comparison to the Beclomethazone Treatment |
| title_fullStr | Topical Effects of Glycirrhizic Acid on Allergic Rhinitis in Comparison to the Beclomethazone Treatment |
| title_full_unstemmed | Topical Effects of Glycirrhizic Acid on Allergic Rhinitis in Comparison to the Beclomethazone Treatment |
| title_short | Topical Effects of Glycirrhizic Acid on Allergic Rhinitis in Comparison to the Beclomethazone Treatment |
| title_sort | topical effects of glycirrhizic acid on allergic rhinitis in comparison to the beclomethazone treatment |
| topic | allergy allergic rhinitis glycyrrhizinic acid beclomethasone |
| url | http://jmp.ir/article-1-125-en.html |
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