Diagnostic value of galactomannan detection in bronchoalveolar lavage fluid in COVID-19 associated invasive pulmonary fungal infection
<b>Objective</b> To analyze the concentration of galactomannan (GM) in bronchoalveolar lavage fluid (BALF) and its value in the diagnosis of COVID-19 related invasive pulmonary fungal infection(IPFI). <b>Methods</b> From 2022 to 2023, 41 patients with COVID-19 related IPFI co...
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| Format: | Article |
| Language: | zho |
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The Editorial Department of Chinese Journal of Clinical Research
2023-09-01
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| Series: | Zhongguo linchuang yanjiu |
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| Online Access: | http://zglcyj.ijournals.cn/zglcyj/ch/reader/view_abstract.aspx?file_no=20230918&flag=1 |
| _version_ | 1797674821680627712 |
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| author | CHENG Zhongle WEI Wei WU Chengxu ZHU Chengyu WANG Zhongxin HUANG Ying XIA Hongdeng |
| author_facet | CHENG Zhongle WEI Wei WU Chengxu ZHU Chengyu WANG Zhongxin HUANG Ying XIA Hongdeng |
| author_sort | CHENG Zhongle |
| collection | DOAJ |
| description | <b>Objective</b> To analyze the concentration of galactomannan (GM) in bronchoalveolar lavage fluid (BALF) and its value in the diagnosis of COVID-19 related invasive pulmonary fungal infection(IPFI). <b>Methods</b> From 2022 to 2023, 41 patients with COVID-19 related IPFI confirmed, clinically diagnosed or to be diagnosed in the First Affiliated Hospital of Anhui Medical University were taken as the experimental group, and 42 patients with simple pneumonia were taken as the control group. Bronchoscopic alveolar lavage was performed in both groups, and the contents of GM in both BALF and serum were detected at the same time. The concentration difference and clinical diagnostic value of GM between the two groups of different specimens were analyzed, and ROC was used to evaluate the diagnostic efficacy. <b>Results</b> Compared with the control group, the experimental group had higher BALF GM concentrations [（2.27±1.78） ng/L <i>vs</i> (0.51±0.28) ng/L, <i>t</i> =6.329, <i>P</i>＜0.01) and serum GM concentrations [(1.57±0.56) ng/L <i>vs</i> (0.32±0.11) ng/L, <i>t</i> =14.190, <i>P</i>＜0.01＝. The optimal cut-off value for diagnosing IPFI with BALF was 1.82 ng/L, with sensitivity and specificity of 77.9% and 89.2%, respectively, and AUC of 0.92 (95%<i>CI</i>: 0.871-0.955). The optimal cut-off value for serum was 0.67 ng/L, with sensitivity and specificity of 64.9% and 92.2%, respectively, and AUC of 0.89 (95%<i>CI</i>: 0.854-0.925). However, the false positive rate of BALF was slightly higher than that of serum (10.8% <i>vs</i> 7.8%). <b>Conclusion</b> GM can be serve of as a good indicator for evaluating IPFI related to COVID-19. The GM detection in BALF has more clinical value in the diagnosis of IPFI than serum.
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| first_indexed | 2024-03-11T22:04:36Z |
| format | Article |
| id | doaj.art-263f4b8220b248a48e0d7a182d66c500 |
| institution | Directory Open Access Journal |
| issn | 1674-8182 |
| language | zho |
| last_indexed | 2024-03-11T22:04:36Z |
| publishDate | 2023-09-01 |
| publisher | The Editorial Department of Chinese Journal of Clinical Research |
| record_format | Article |
| series | Zhongguo linchuang yanjiu |
| spelling | doaj.art-263f4b8220b248a48e0d7a182d66c5002023-09-25T07:06:32ZzhoThe Editorial Department of Chinese Journal of Clinical ResearchZhongguo linchuang yanjiu1674-81822023-09-013691366136910.13429/j.cnki.cjcr.2023.09.018Diagnostic value of galactomannan detection in bronchoalveolar lavage fluid in COVID-19 associated invasive pulmonary fungal infectionCHENG Zhongle0WEI Wei1WU Chengxu2ZHU Chengyu3WANG Zhongxin4HUANG Ying5XIA Hongdeng6Laboratory Department, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, ChinaDepartment of Pediatrics, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, ChinaNanchang University Queen Mary School, Nanchang, Jiangxi 330006, ChinaAnhui Medical University, Hefei, Anhui 230000, ChinaLaboratory Department, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, ChinaLaboratory Department, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, ChinaLaboratory Department, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, China<b>Objective</b> To analyze the concentration of galactomannan (GM) in bronchoalveolar lavage fluid (BALF) and its value in the diagnosis of COVID-19 related invasive pulmonary fungal infection(IPFI). <b>Methods</b> From 2022 to 2023, 41 patients with COVID-19 related IPFI confirmed, clinically diagnosed or to be diagnosed in the First Affiliated Hospital of Anhui Medical University were taken as the experimental group, and 42 patients with simple pneumonia were taken as the control group. Bronchoscopic alveolar lavage was performed in both groups, and the contents of GM in both BALF and serum were detected at the same time. The concentration difference and clinical diagnostic value of GM between the two groups of different specimens were analyzed, and ROC was used to evaluate the diagnostic efficacy. <b>Results</b> Compared with the control group, the experimental group had higher BALF GM concentrations [（2.27±1.78） ng/L <i>vs</i> (0.51±0.28) ng/L, <i>t</i> =6.329, <i>P</i>＜0.01) and serum GM concentrations [(1.57±0.56) ng/L <i>vs</i> (0.32±0.11) ng/L, <i>t</i> =14.190, <i>P</i>＜0.01＝. The optimal cut-off value for diagnosing IPFI with BALF was 1.82 ng/L, with sensitivity and specificity of 77.9% and 89.2%, respectively, and AUC of 0.92 (95%<i>CI</i>: 0.871-0.955). The optimal cut-off value for serum was 0.67 ng/L, with sensitivity and specificity of 64.9% and 92.2%, respectively, and AUC of 0.89 (95%<i>CI</i>: 0.854-0.925). However, the false positive rate of BALF was slightly higher than that of serum (10.8% <i>vs</i> 7.8%). <b>Conclusion</b> GM can be serve of as a good indicator for evaluating IPFI related to COVID-19. The GM detection in BALF has more clinical value in the diagnosis of IPFI than serum. http://zglcyj.ijournals.cn/zglcyj/ch/reader/view_abstract.aspx?file_no=20230918&flag=1invasive fungal infectionbronchoalveolar lavage fluidgalactomannancovid-19 |
| spellingShingle | CHENG Zhongle WEI Wei WU Chengxu ZHU Chengyu WANG Zhongxin HUANG Ying XIA Hongdeng Diagnostic value of galactomannan detection in bronchoalveolar lavage fluid in COVID-19 associated invasive pulmonary fungal infection Zhongguo linchuang yanjiu invasive fungal infection bronchoalveolar lavage fluid galactomannan covid-19 |
| title | Diagnostic value of galactomannan detection in bronchoalveolar lavage fluid in COVID-19 associated invasive pulmonary fungal infection |
| title_full | Diagnostic value of galactomannan detection in bronchoalveolar lavage fluid in COVID-19 associated invasive pulmonary fungal infection |
| title_fullStr | Diagnostic value of galactomannan detection in bronchoalveolar lavage fluid in COVID-19 associated invasive pulmonary fungal infection |
| title_full_unstemmed | Diagnostic value of galactomannan detection in bronchoalveolar lavage fluid in COVID-19 associated invasive pulmonary fungal infection |
| title_short | Diagnostic value of galactomannan detection in bronchoalveolar lavage fluid in COVID-19 associated invasive pulmonary fungal infection |
| title_sort | diagnostic value of galactomannan detection in bronchoalveolar lavage fluid in covid 19 associated invasive pulmonary fungal infection |
| topic | invasive fungal infection bronchoalveolar lavage fluid galactomannan covid-19 |
| url | http://zglcyj.ijournals.cn/zglcyj/ch/reader/view_abstract.aspx?file_no=20230918&flag=1 |
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