The PenV vacuolar membrane protein that controls penicillin biosynthesis is a putative member of a subfamily of stress-gated transient receptor calcium channels
The penV gene of Penicillium chrysogenum, involved in the control of penicillin biosynthesis, encodes a large-size (832 amino acids) putative transient receptor potential (TRP) ion channel that might interact with different ligands and other proteins. It belongs to a novel class of stress-gated TRP...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-01-01
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| Series: | Current Research in Biotechnology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590262821000344 |
| _version_ | 1819096050623840256 |
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| author | Juan F. Martín Paloma Liras |
| author_facet | Juan F. Martín Paloma Liras |
| author_sort | Juan F. Martín |
| collection | DOAJ |
| description | The penV gene of Penicillium chrysogenum, involved in the control of penicillin biosynthesis, encodes a large-size (832 amino acids) putative transient receptor potential (TRP) ion channel that might interact with different ligands and other proteins. It belongs to a novel class of stress-gated TRP channels similar to the calcium transporter CSC type TRP of Arabidopsis thaliana and yeasts. These TRP proteins contains eleven and twelve transmembrane domains in yeasts and fungi, respectively, with one large interdomain loop and a C-terminal unstructured region that allows the interaction with ligands. The physiological action of many TRPs is mediated by calcium signalling. Ca2+ is released from the vacuoles into the cytosol in response to external stressing factors. PenV increases expression of the two late genes of penicillin biosynthesis (pcbC and penDE) probably by a calcium signalling cascade. The possible involvement of TRPs in the sensing of ligands or in interaction with other proteins, e.g. calmodulin, is a novel and interesting aspect of regulation of the biosynthesis of secondary metabolites in fungi. |
| first_indexed | 2024-12-21T23:53:02Z |
| format | Article |
| id | doaj.art-263fccd2e316498086ed74d0e6660266 |
| institution | Directory Open Access Journal |
| issn | 2590-2628 |
| language | English |
| last_indexed | 2024-12-21T23:53:02Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Biotechnology |
| spelling | doaj.art-263fccd2e316498086ed74d0e66602662022-12-21T18:45:53ZengElsevierCurrent Research in Biotechnology2590-26282021-01-013317322The PenV vacuolar membrane protein that controls penicillin biosynthesis is a putative member of a subfamily of stress-gated transient receptor calcium channelsJuan F. Martín0Paloma Liras1Corresponding author.; Departamento de Biología Molecular, Área de Microbiología, Universidad de León, León, SpainDepartamento de Biología Molecular, Área de Microbiología, Universidad de León, León, SpainThe penV gene of Penicillium chrysogenum, involved in the control of penicillin biosynthesis, encodes a large-size (832 amino acids) putative transient receptor potential (TRP) ion channel that might interact with different ligands and other proteins. It belongs to a novel class of stress-gated TRP channels similar to the calcium transporter CSC type TRP of Arabidopsis thaliana and yeasts. These TRP proteins contains eleven and twelve transmembrane domains in yeasts and fungi, respectively, with one large interdomain loop and a C-terminal unstructured region that allows the interaction with ligands. The physiological action of many TRPs is mediated by calcium signalling. Ca2+ is released from the vacuoles into the cytosol in response to external stressing factors. PenV increases expression of the two late genes of penicillin biosynthesis (pcbC and penDE) probably by a calcium signalling cascade. The possible involvement of TRPs in the sensing of ligands or in interaction with other proteins, e.g. calmodulin, is a novel and interesting aspect of regulation of the biosynthesis of secondary metabolites in fungi.http://www.sciencedirect.com/science/article/pii/S2590262821000344Calcium transportFilamentous fungiInteracting ligandsPenicillin biosynthesisPenicillium chrysogenumPenV |
| spellingShingle | Juan F. Martín Paloma Liras The PenV vacuolar membrane protein that controls penicillin biosynthesis is a putative member of a subfamily of stress-gated transient receptor calcium channels Current Research in Biotechnology Calcium transport Filamentous fungi Interacting ligands Penicillin biosynthesis Penicillium chrysogenum PenV |
| title | The PenV vacuolar membrane protein that controls penicillin biosynthesis is a putative member of a subfamily of stress-gated transient receptor calcium channels |
| title_full | The PenV vacuolar membrane protein that controls penicillin biosynthesis is a putative member of a subfamily of stress-gated transient receptor calcium channels |
| title_fullStr | The PenV vacuolar membrane protein that controls penicillin biosynthesis is a putative member of a subfamily of stress-gated transient receptor calcium channels |
| title_full_unstemmed | The PenV vacuolar membrane protein that controls penicillin biosynthesis is a putative member of a subfamily of stress-gated transient receptor calcium channels |
| title_short | The PenV vacuolar membrane protein that controls penicillin biosynthesis is a putative member of a subfamily of stress-gated transient receptor calcium channels |
| title_sort | penv vacuolar membrane protein that controls penicillin biosynthesis is a putative member of a subfamily of stress gated transient receptor calcium channels |
| topic | Calcium transport Filamentous fungi Interacting ligands Penicillin biosynthesis Penicillium chrysogenum PenV |
| url | http://www.sciencedirect.com/science/article/pii/S2590262821000344 |
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