Loss of <i>Cnot6l</i> Impairs Inosine RNA Modifications in Mouse Oocytes

Loss of <i>Cnot6l</i> Impairs Inosine RNA Modifications in Mouse Oocytes

Mammalian oocytes must degrade maternal transcripts through a process called translational mRNA decay, in which maternal mRNA undergoes translational activation, followed by deadenylation and mRNA decay. Once a transcript is translationally activated, it becomes deadenylated by the CCR4-NOT complex....

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Bibliographic Details
Main Authors: Pavla Brachova, Nehemiah S. Alvarez, Lane K. Christenson
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
inosine RNA modifications
oocyte
RNA decay
CCR4-NOT
GV-to-MII transition
polysome
Online Access:https://www.mdpi.com/1422-0067/22/3/1191

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