Metabolic Profile Characterization of Different Thyroid Nodules Using FTIR Spectroscopy: A Review

Thyroid cancer’s incidence has increased in the last decades, and its diagnosis can be a challenge. Further and complementary testing based in biochemical alterations may be important to correctly identify thyroid cancer and prevent unnecessary surgery. Fourier-transform infrared (FTIR) spectroscopy...

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Bibliographic Details
Main Authors: Vanessa Neto, Sara Esteves-Ferreira, Isabel Inácio, Márcia Alves, Rosa Dantas, Idália Almeida, Joana Guimarães, Teresa Azevedo, Alexandra Nunes
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Metabolites
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Online Access:https://www.mdpi.com/2218-1989/12/1/53
Description
Summary:Thyroid cancer’s incidence has increased in the last decades, and its diagnosis can be a challenge. Further and complementary testing based in biochemical alterations may be important to correctly identify thyroid cancer and prevent unnecessary surgery. Fourier-transform infrared (FTIR) spectroscopy is a metabolomic technique that has already shown promising results in cancer metabolome analysis of neoplastic thyroid tissue, in the identification and classification of prostate tumor tissues and of breast carcinoma, among others. This work aims to gather and discuss published information on the ability of FTIR spectroscopy to be used in metabolomic studies of the thyroid, including discriminating between benign and malignant thyroid samples and grading and classifying different types of thyroid tumors.
ISSN:2218-1989