Resveratrol elongates the lifespan and improves antioxidant activity in the silkworm Bombyx mori
A number of research has shown that the plant polyphenol resveratrol, one of the most prominent small molecules, has beneficial protective effects in multiple organisms, including worms, flies, and killifish. To understand the effects of resveratrol on lifespan, we evaluated its effects in the silkw...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-06-01
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| Series: | Journal of Pharmaceutical Analysis |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2095177919311700 |
| _version_ | 1818456325825232896 |
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| author | Jiangbo Song Lian Liu Kaige Hao Shuang Mao Yongxi Tang Xiaoling Tong Fangyin Dai |
| author_facet | Jiangbo Song Lian Liu Kaige Hao Shuang Mao Yongxi Tang Xiaoling Tong Fangyin Dai |
| author_sort | Jiangbo Song |
| collection | DOAJ |
| description | A number of research has shown that the plant polyphenol resveratrol, one of the most prominent small molecules, has beneficial protective effects in multiple organisms, including worms, flies, and killifish. To understand the effects of resveratrol on lifespan, we evaluated its effects in the silkworm Bombyx mori. In this study, we found that lifespan was significantly prolonged in both female and male silkworms treated with resveratrol. Silkworm larval weight was significantly increased from day 3 of the 5th larval instar (L5D3) to day 7 of the 5th larval instar (L5D7). However, the weight of the pupa, cocoon, and total cocoon was not significantly different in female silkworms with resveratrol treatment than that in controls. Meanwhile, resveratrol significantly improved the thermotolerance of the silkworms, which enhanced their survival rate. Moreover, antioxidant activity was increased by resveratrol in both female and male silkworms. Furthermore, an antioxidant-related signalling pathway, SIRT7-FoxO-GST, was activated in silkworms with resveratrol treatment. Collectively, these results help us to understand the molecular pathways underlying resveratrol induced pro-longevity effects and indicate that silkworm is a promising animal model for evaluating the effects of lifespan-extending drugs. |
| first_indexed | 2024-12-14T22:24:53Z |
| format | Article |
| id | doaj.art-26438e99ea0b487ea31bce554f6d22e4 |
| institution | Directory Open Access Journal |
| issn | 2095-1779 |
| language | English |
| last_indexed | 2024-12-14T22:24:53Z |
| publishDate | 2021-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmaceutical Analysis |
| spelling | doaj.art-26438e99ea0b487ea31bce554f6d22e42022-12-21T22:45:23ZengElsevierJournal of Pharmaceutical Analysis2095-17792021-06-01113374382Resveratrol elongates the lifespan and improves antioxidant activity in the silkworm Bombyx moriJiangbo Song0Lian Liu1Kaige Hao2Shuang Mao3Yongxi Tang4Xiaoling Tong5Fangyin Dai6State Key Laboratory of Silkworm Genome Biology; Key Laboratory for Sericulture Biology and Genetic Breeding, Ministry of Agriculture and Rural Affairs; College of Biotechnology, Southwest University, No. 2 Tiansheng Road, Beibei District, Chongqing, 400715, ChinaState Key Laboratory of Silkworm Genome Biology; Key Laboratory for Sericulture Biology and Genetic Breeding, Ministry of Agriculture and Rural Affairs; College of Biotechnology, Southwest University, No. 2 Tiansheng Road, Beibei District, Chongqing, 400715, ChinaState Key Laboratory of Silkworm Genome Biology; Key Laboratory for Sericulture Biology and Genetic Breeding, Ministry of Agriculture and Rural Affairs; College of Biotechnology, Southwest University, No. 2 Tiansheng Road, Beibei District, Chongqing, 400715, ChinaState Key Laboratory of Silkworm Genome Biology; Key Laboratory for Sericulture Biology and Genetic Breeding, Ministry of Agriculture and Rural Affairs; College of Biotechnology, Southwest University, No. 2 Tiansheng Road, Beibei District, Chongqing, 400715, ChinaState Key Laboratory of Silkworm Genome Biology; Key Laboratory for Sericulture Biology and Genetic Breeding, Ministry of Agriculture and Rural Affairs; College of Biotechnology, Southwest University, No. 2 Tiansheng Road, Beibei District, Chongqing, 400715, ChinaState Key Laboratory of Silkworm Genome Biology; Key Laboratory for Sericulture Biology and Genetic Breeding, Ministry of Agriculture and Rural Affairs; College of Biotechnology, Southwest University, No. 2 Tiansheng Road, Beibei District, Chongqing, 400715, ChinaCorresponding author.; State Key Laboratory of Silkworm Genome Biology; Key Laboratory for Sericulture Biology and Genetic Breeding, Ministry of Agriculture and Rural Affairs; College of Biotechnology, Southwest University, No. 2 Tiansheng Road, Beibei District, Chongqing, 400715, ChinaA number of research has shown that the plant polyphenol resveratrol, one of the most prominent small molecules, has beneficial protective effects in multiple organisms, including worms, flies, and killifish. To understand the effects of resveratrol on lifespan, we evaluated its effects in the silkworm Bombyx mori. In this study, we found that lifespan was significantly prolonged in both female and male silkworms treated with resveratrol. Silkworm larval weight was significantly increased from day 3 of the 5th larval instar (L5D3) to day 7 of the 5th larval instar (L5D7). However, the weight of the pupa, cocoon, and total cocoon was not significantly different in female silkworms with resveratrol treatment than that in controls. Meanwhile, resveratrol significantly improved the thermotolerance of the silkworms, which enhanced their survival rate. Moreover, antioxidant activity was increased by resveratrol in both female and male silkworms. Furthermore, an antioxidant-related signalling pathway, SIRT7-FoxO-GST, was activated in silkworms with resveratrol treatment. Collectively, these results help us to understand the molecular pathways underlying resveratrol induced pro-longevity effects and indicate that silkworm is a promising animal model for evaluating the effects of lifespan-extending drugs.http://www.sciencedirect.com/science/article/pii/S2095177919311700ResveratrolBombyx moriLifespanAntioxidant activitySIRT7-FoxO-GST pathway |
| spellingShingle | Jiangbo Song Lian Liu Kaige Hao Shuang Mao Yongxi Tang Xiaoling Tong Fangyin Dai Resveratrol elongates the lifespan and improves antioxidant activity in the silkworm Bombyx mori Journal of Pharmaceutical Analysis Resveratrol Bombyx mori Lifespan Antioxidant activity SIRT7-FoxO-GST pathway |
| title | Resveratrol elongates the lifespan and improves antioxidant activity in the silkworm Bombyx mori |
| title_full | Resveratrol elongates the lifespan and improves antioxidant activity in the silkworm Bombyx mori |
| title_fullStr | Resveratrol elongates the lifespan and improves antioxidant activity in the silkworm Bombyx mori |
| title_full_unstemmed | Resveratrol elongates the lifespan and improves antioxidant activity in the silkworm Bombyx mori |
| title_short | Resveratrol elongates the lifespan and improves antioxidant activity in the silkworm Bombyx mori |
| title_sort | resveratrol elongates the lifespan and improves antioxidant activity in the silkworm bombyx mori |
| topic | Resveratrol Bombyx mori Lifespan Antioxidant activity SIRT7-FoxO-GST pathway |
| url | http://www.sciencedirect.com/science/article/pii/S2095177919311700 |
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