Photodynamic therapy for precancer diseases and cervical cancer (review of literature)

The paper presents the results of literature data analysis on the main directions of precancerous diseases of the cervix uteri and cervical cancer treatment. Side effects following surgery or radiation treatment can lead to structural deformities, scarring, hyperpigmentation, systemic side effects,...

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Main Authors: A. V. Gilyadova, Yu. S. Romanko, A. A. Ishchenko, S. V. Samoilova, A. A. Shiryaev, P. M. Alekseeva, K. T. Efendiev, I. V. Reshetov
Format: Article
Language:Russian
Published: Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association" 2022-02-01
Series:Biomedical Photonics
Subjects:
Online Access:https://www.pdt-journal.com/jour/article/view/519
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author A. V. Gilyadova
Yu. S. Romanko
A. A. Ishchenko
S. V. Samoilova
A. A. Shiryaev
P. M. Alekseeva
K. T. Efendiev
I. V. Reshetov
author_facet A. V. Gilyadova
Yu. S. Romanko
A. A. Ishchenko
S. V. Samoilova
A. A. Shiryaev
P. M. Alekseeva
K. T. Efendiev
I. V. Reshetov
author_sort A. V. Gilyadova
collection DOAJ
description The paper presents the results of literature data analysis on the main directions of precancerous diseases of the cervix uteri and cervical cancer treatment. Side effects following surgery or radiation treatment can lead to structural deformities, scarring, hyperpigmentation, systemic side effects, and destruction of normal tissue. In addition, the use of traditional methods of treatment can cause multidrug resistance, which will lead to ineffective treatment and the development of a relapse of the disease. To avoid toxicity and reduce side effects, alternative treatment strategies have been proposed. Photodynamic therapy (PDT) is a promising organ-preserving highly selective method for treating cervical neoplasia, which includes two stages: the introduction of a photosensitizer and local exposure to directed light radiation. A number of studies have demonstrated the high clinical efficacy of this method in the treatment of patients with cervical neoplasia and carriage of human papillomavirus infection without adverse consequences for fertility. The use of PDT contributes to the successful outcome of the treatment of pathological foci on the mucous membrane of the cervix, the effectiveness and safety of the method is ensured by the selective effect on tissues. In the course of treatment, normal surrounding tissues are not damaged, there is no gross scarring and stenosis of the cervical canal, thereby PDT allows maintaining the normal anatomical and functional characteristics of the cervix.
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spelling doaj.art-2645337430f94587a7d9cbb58d067cc22023-03-13T07:12:31ZrusNon-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association"Biomedical Photonics2413-94322022-02-01104596710.24931/2413-9432-2021-10-4-59-67244Photodynamic therapy for precancer diseases and cervical cancer (review of literature)A. V. Gilyadova0Yu. S. Romanko1A. A. Ishchenko2S. V. Samoilova3A. A. Shiryaev4P. M. Alekseeva5K. T. Efendiev6I. V. Reshetov7Первый Московский государственный медицинский университет им. И.М. Сеченова; Лечебно-реабилитационный центр МинздраваПервый Московский государственный медицинский университет им. И.М. СеченоваЛечебно-реабилитационный центр МинздраваПервый Московский государственный медицинский университет им. И.М. СеченоваПервый Московский государственный медицинский университет им. И.М. СеченоваФИЦ «Институт общей физики им. А.М. Прохорова РАН»; Национальный исследовательский ядерный университет МИФИФИЦ «Институт общей физики им. А.М. Прохорова РАН»; Национальный исследовательский ядерный университет МИФИПервый Московский государственный медицинский университет им. И.М. Сеченова; Федеральный научно-клинический центр специализированных видов медицинской помощи и медицинских технологий ФМБА; Московский университет им. С.Ю. ВиттеThe paper presents the results of literature data analysis on the main directions of precancerous diseases of the cervix uteri and cervical cancer treatment. Side effects following surgery or radiation treatment can lead to structural deformities, scarring, hyperpigmentation, systemic side effects, and destruction of normal tissue. In addition, the use of traditional methods of treatment can cause multidrug resistance, which will lead to ineffective treatment and the development of a relapse of the disease. To avoid toxicity and reduce side effects, alternative treatment strategies have been proposed. Photodynamic therapy (PDT) is a promising organ-preserving highly selective method for treating cervical neoplasia, which includes two stages: the introduction of a photosensitizer and local exposure to directed light radiation. A number of studies have demonstrated the high clinical efficacy of this method in the treatment of patients with cervical neoplasia and carriage of human papillomavirus infection without adverse consequences for fertility. The use of PDT contributes to the successful outcome of the treatment of pathological foci on the mucous membrane of the cervix, the effectiveness and safety of the method is ensured by the selective effect on tissues. In the course of treatment, normal surrounding tissues are not damaged, there is no gross scarring and stenosis of the cervical canal, thereby PDT allows maintaining the normal anatomical and functional characteristics of the cervix.https://www.pdt-journal.com/jour/article/view/519рак шейки маткидисплазия шейки маткивирус папилломы человекафотодинамическая терапияфотосенсибилизатор
spellingShingle A. V. Gilyadova
Yu. S. Romanko
A. A. Ishchenko
S. V. Samoilova
A. A. Shiryaev
P. M. Alekseeva
K. T. Efendiev
I. V. Reshetov
Photodynamic therapy for precancer diseases and cervical cancer (review of literature)
Biomedical Photonics
рак шейки матки
дисплазия шейки матки
вирус папилломы человека
фотодинамическая терапия
фотосенсибилизатор
title Photodynamic therapy for precancer diseases and cervical cancer (review of literature)
title_full Photodynamic therapy for precancer diseases and cervical cancer (review of literature)
title_fullStr Photodynamic therapy for precancer diseases and cervical cancer (review of literature)
title_full_unstemmed Photodynamic therapy for precancer diseases and cervical cancer (review of literature)
title_short Photodynamic therapy for precancer diseases and cervical cancer (review of literature)
title_sort photodynamic therapy for precancer diseases and cervical cancer review of literature
topic рак шейки матки
дисплазия шейки матки
вирус папилломы человека
фотодинамическая терапия
фотосенсибилизатор
url https://www.pdt-journal.com/jour/article/view/519
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