Saponins from Swartzia langsdorffii: biological activities
The presence of saponins and the molluscicidal activity of the roots, leaves, seeds and fruits of Swartzia langsdorffii Raddi (Leguminosae) against Biomphalaria glabrata adults and eggs were investigated. The roots, seeds and fruits were macerated in 95% ethanol. These extracts exerted a significant...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2003-01-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762003000500022 |
| _version_ | 1797721333081047040 |
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| author | Magalhães Aderbal Farias Tozzi Ana Maria Goulart de Azevedo Santos Celira Caparica Serrano Deborah Regina Zanotti-Magalhães Eliana Maria Magalhães Eva Gonçalves Magalhães Luiz Augusto |
| author_facet | Magalhães Aderbal Farias Tozzi Ana Maria Goulart de Azevedo Santos Celira Caparica Serrano Deborah Regina Zanotti-Magalhães Eliana Maria Magalhães Eva Gonçalves Magalhães Luiz Augusto |
| author_sort | Magalhães Aderbal Farias |
| collection | DOAJ |
| description | The presence of saponins and the molluscicidal activity of the roots, leaves, seeds and fruits of Swartzia langsdorffii Raddi (Leguminosae) against Biomphalaria glabrata adults and eggs were investigated. The roots, seeds and fruits were macerated in 95% ethanol. These extracts exerted a significant molluscicidal activity against B. glabrata, up to a dilution of 100 mg/l. Four mixtures (A2, B2, C and D) of triterpenoid oleanane type saponins were chromatographically isolated from the seed and fruit extracts. Two known saponins (1 and 2) were identified as beta-D-glucopyranosyl-[alpha-L-rhamnopyranosyl-(1->3)- beta-D-glucuronopyranosyl-(1->3)]-3beta-hydroxyolean-12-ene-28 -oate, and beta-D-glucopyranosyl-(1->3)-beta-D-glucuronopyranosyl-(1 ->3)]-3beta-hydroxyolean-12-ene-28-oate, respectively. These two saponins were present in all the mixtures, together with other triterpenoid oleane type saponins, which were shown to be less polar, by reversed-phase HPLC. The saponin identifications were based on spectral evidence, including ¹H-¹H two-dimensional correlation spectroscopy, nuclear Overhauser and exchange spectroscopy, heteronuclear multiple quantum coherence, and heteronuclear multiple-bond connectivity experiments. The toxicity of S. langsdorffii saponins to non-target organisms was prescreened by the brine shrimp lethality test. |
| first_indexed | 2024-03-12T09:31:54Z |
| format | Article |
| id | doaj.art-2645c849a28d4131be950625e0d46378 |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T09:31:54Z |
| publishDate | 2003-01-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-2645c849a28d4131be950625e0d463782023-09-02T13:54:00ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602003-01-01985713718Saponins from Swartzia langsdorffii: biological activitiesMagalhães Aderbal FariasTozzi Ana Maria Goulart de AzevedoSantos Celira CaparicaSerrano Deborah ReginaZanotti-Magalhães Eliana MariaMagalhães Eva GonçalvesMagalhães Luiz AugustoThe presence of saponins and the molluscicidal activity of the roots, leaves, seeds and fruits of Swartzia langsdorffii Raddi (Leguminosae) against Biomphalaria glabrata adults and eggs were investigated. The roots, seeds and fruits were macerated in 95% ethanol. These extracts exerted a significant molluscicidal activity against B. glabrata, up to a dilution of 100 mg/l. Four mixtures (A2, B2, C and D) of triterpenoid oleanane type saponins were chromatographically isolated from the seed and fruit extracts. Two known saponins (1 and 2) were identified as beta-D-glucopyranosyl-[alpha-L-rhamnopyranosyl-(1->3)- beta-D-glucuronopyranosyl-(1->3)]-3beta-hydroxyolean-12-ene-28 -oate, and beta-D-glucopyranosyl-(1->3)-beta-D-glucuronopyranosyl-(1 ->3)]-3beta-hydroxyolean-12-ene-28-oate, respectively. These two saponins were present in all the mixtures, together with other triterpenoid oleane type saponins, which were shown to be less polar, by reversed-phase HPLC. The saponin identifications were based on spectral evidence, including ¹H-¹H two-dimensional correlation spectroscopy, nuclear Overhauser and exchange spectroscopy, heteronuclear multiple quantum coherence, and heteronuclear multiple-bond connectivity experiments. The toxicity of S. langsdorffii saponins to non-target organisms was prescreened by the brine shrimp lethality test.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762003000500022Swartzia langsdorffiiLeguminosaechemotaxonomysaponinsmolluscicidal activityschistosomiasisArtemia salina |
| spellingShingle | Magalhães Aderbal Farias Tozzi Ana Maria Goulart de Azevedo Santos Celira Caparica Serrano Deborah Regina Zanotti-Magalhães Eliana Maria Magalhães Eva Gonçalves Magalhães Luiz Augusto Saponins from Swartzia langsdorffii: biological activities Memorias do Instituto Oswaldo Cruz Swartzia langsdorffii Leguminosae chemotaxonomy saponins molluscicidal activity schistosomiasis Artemia salina |
| title | Saponins from Swartzia langsdorffii: biological activities |
| title_full | Saponins from Swartzia langsdorffii: biological activities |
| title_fullStr | Saponins from Swartzia langsdorffii: biological activities |
| title_full_unstemmed | Saponins from Swartzia langsdorffii: biological activities |
| title_short | Saponins from Swartzia langsdorffii: biological activities |
| title_sort | saponins from swartzia langsdorffii biological activities |
| topic | Swartzia langsdorffii Leguminosae chemotaxonomy saponins molluscicidal activity schistosomiasis Artemia salina |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762003000500022 |
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