Maternal obesity and resistance to breast cancer treatments among offspring: Link to gut dysbiosis
Abstract Background About 50 000 new cases of cancer in the United States are attributed to obesity. The adverse effects of obesity on breast cancer may be most profound when affecting the early development; that is, in the womb of a pregnant obese mother. Maternal obesity has several long‐lasting a...
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| Format: | Article |
| Language: | English |
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Wiley
2022-12-01
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| Series: | Cancer Reports |
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| Online Access: | https://doi.org/10.1002/cnr2.1752 |
| _version_ | 1797978680861917184 |
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| author | Fabia deOliveira Andrade Vivek Verma Leena Hilakivi‐Clarke |
| author_facet | Fabia deOliveira Andrade Vivek Verma Leena Hilakivi‐Clarke |
| author_sort | Fabia deOliveira Andrade |
| collection | DOAJ |
| description | Abstract Background About 50 000 new cases of cancer in the United States are attributed to obesity. The adverse effects of obesity on breast cancer may be most profound when affecting the early development; that is, in the womb of a pregnant obese mother. Maternal obesity has several long‐lasting adverse health effects on the offspring, including increasing offspring's breast cancer risk and mortality. Gut microbiota is a player in obesity as well as may impact breast carcinogenesis. Gut microbiota is established early in life and the microbial composition of an infant's gut becomes permanently dysregulated because of maternal obesity. Metabolites from the microbiota, especially short chain fatty acids (SCFAs), play a critical role in mediating the effect of gut bacteria on multiple biological functions, such as immune system, including tumor immune responses. Recent Findings Maternal obesity can pre‐program daughter's breast cancer to be more aggressive, less responsive to treatments and consequently more likely to cause breast cancer related death. Maternal obesity may also induce poor response to immune checkpoint inhibitor (ICB) therapy through increased abundance of inflammation associated microbiome and decreased abundance of bacteria that are linked to production of SCFAs. Dietary interventions that increase the abundance of bacteria producing SCFAs potentially reverses offspring's resistance to breast cancer therapy. Conclusion Since immunotherapies have emerged as highly effective treatments for many cancers, albeit there is an urgent need to enlarge the patient population who will be responsive to these treatments. One of the factors which may cause ICB refractoriness could be maternal obesity, based on its effects on the microbiota markers of ICB therapy response among the offspring. Since about 40% of children are born to obese mothers in the Western societies, it is important to determine if maternal obesity impairs offspring's response to cancer immunotherapies. |
| first_indexed | 2024-04-11T05:27:56Z |
| format | Article |
| id | doaj.art-2645d0002dcf485c9334b7128bb20ca7 |
| institution | Directory Open Access Journal |
| issn | 2573-8348 |
| language | English |
| last_indexed | 2024-04-11T05:27:56Z |
| publishDate | 2022-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Reports |
| spelling | doaj.art-2645d0002dcf485c9334b7128bb20ca72022-12-23T04:42:20ZengWileyCancer Reports2573-83482022-12-01512n/an/a10.1002/cnr2.1752Maternal obesity and resistance to breast cancer treatments among offspring: Link to gut dysbiosisFabia deOliveira Andrade0Vivek Verma1Leena Hilakivi‐Clarke2The Hormel Institute, University of Minnesota Austin Minnesota USAThe Hormel Institute, University of Minnesota Austin Minnesota USAThe Hormel Institute, University of Minnesota Austin Minnesota USAAbstract Background About 50 000 new cases of cancer in the United States are attributed to obesity. The adverse effects of obesity on breast cancer may be most profound when affecting the early development; that is, in the womb of a pregnant obese mother. Maternal obesity has several long‐lasting adverse health effects on the offspring, including increasing offspring's breast cancer risk and mortality. Gut microbiota is a player in obesity as well as may impact breast carcinogenesis. Gut microbiota is established early in life and the microbial composition of an infant's gut becomes permanently dysregulated because of maternal obesity. Metabolites from the microbiota, especially short chain fatty acids (SCFAs), play a critical role in mediating the effect of gut bacteria on multiple biological functions, such as immune system, including tumor immune responses. Recent Findings Maternal obesity can pre‐program daughter's breast cancer to be more aggressive, less responsive to treatments and consequently more likely to cause breast cancer related death. Maternal obesity may also induce poor response to immune checkpoint inhibitor (ICB) therapy through increased abundance of inflammation associated microbiome and decreased abundance of bacteria that are linked to production of SCFAs. Dietary interventions that increase the abundance of bacteria producing SCFAs potentially reverses offspring's resistance to breast cancer therapy. Conclusion Since immunotherapies have emerged as highly effective treatments for many cancers, albeit there is an urgent need to enlarge the patient population who will be responsive to these treatments. One of the factors which may cause ICB refractoriness could be maternal obesity, based on its effects on the microbiota markers of ICB therapy response among the offspring. Since about 40% of children are born to obese mothers in the Western societies, it is important to determine if maternal obesity impairs offspring's response to cancer immunotherapies.https://doi.org/10.1002/cnr2.1752gut microbiomeimmunotherapymaternal obesityoffspringshort chain fatty acids |
| spellingShingle | Fabia deOliveira Andrade Vivek Verma Leena Hilakivi‐Clarke Maternal obesity and resistance to breast cancer treatments among offspring: Link to gut dysbiosis Cancer Reports gut microbiome immunotherapy maternal obesity offspring short chain fatty acids |
| title | Maternal obesity and resistance to breast cancer treatments among offspring: Link to gut dysbiosis |
| title_full | Maternal obesity and resistance to breast cancer treatments among offspring: Link to gut dysbiosis |
| title_fullStr | Maternal obesity and resistance to breast cancer treatments among offspring: Link to gut dysbiosis |
| title_full_unstemmed | Maternal obesity and resistance to breast cancer treatments among offspring: Link to gut dysbiosis |
| title_short | Maternal obesity and resistance to breast cancer treatments among offspring: Link to gut dysbiosis |
| title_sort | maternal obesity and resistance to breast cancer treatments among offspring link to gut dysbiosis |
| topic | gut microbiome immunotherapy maternal obesity offspring short chain fatty acids |
| url | https://doi.org/10.1002/cnr2.1752 |
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