Bcl6 Preserves the Suppressive Function of Regulatory T Cells During Tumorigenesis

Bcl6 Preserves the Suppressive Function of Regulatory T Cells During Tumorigenesis

During tumorigenesis, tumor infiltrating regulatory T (Treg) cells restrict the function of effector T cells in tumor microenvironment and thereby promoting tumor growth. The anti-tumor activity of effector T cells can be therapeutically unleashed, and is now being exploited for the treatment of var...

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Bibliographic Details
Main Authors: Yiding Li, Zhiming Wang, Huayu Lin, Lisha Wang, Xiangyu Chen, Qiao Liu, Qianfei Zuo, Jianjun Hu, Haoqiang Wang, Junyi Guo, Luoyingzi Xie, Jianfang Tang, Zhirong Li, Li Hu, Litian Xu, Xinyuan Zhou, Lilin Ye, Qizhao Huang, Lifan Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Immunology
Subjects:
Bcl6
Treg
tumorigenesis
checkpoint blockade therapy
anti-tumor immunity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00806/full

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