Advanced Pediatric Diffuse Pontine Glioma Murine Models Pave the Way towards Precision Medicine

Advanced Pediatric Diffuse Pontine Glioma Murine Models Pave the Way towards Precision Medicine

Diffuse intrinsic pontine gliomas (DIPGs) account for ~15% of pediatric brain tumors, which invariably present with poor survival regardless of treatment mode. Several seminal studies have revealed that 80% of DIPGs harbor H3K27M mutation coded by <i>HIST1H3B</i>, <i>HIST1H3C</i...

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Bibliographic Details
Main Authors:	Zirong Chen, Peng Peng, Xiaolin Zhang, Barbara Mania-Farnell, Guifa Xi, Feng Wan
Format:	Article
Language:	English
Published:	MDPI AG 2021-03-01
Series:	Cancers
Subjects:	diffuse intrinsic pontine glioma molecular biology patient derived xenografts genetically engineered mouse model humanized mouse model
Online Access:	https://www.mdpi.com/2072-6694/13/5/1114

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