The Impacts of Cord Blood Cotinine and Glutathione-S-Transferase Gene Polymorphisms on Birth Outcome
This study aimed to investigate the association between cord blood cotinine levels and birth outcome, and to determine whether fetal metabolic gene polymorphisms of glutathione-S-transferase (GST) modulate the effect of environmental tobacco smoke exposure during pregnancy. Methods: This study inclu...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-08-01
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| Series: | Pediatrics and Neonatology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957217300165 |
| _version_ | 1818271551352471552 |
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| author | Kuan-Han Huang An-Kuo Chou Suh-Fang Jeng Sharon Ng Chia-Jung Hsieh Mei-Huei Chen Pau-Chung Chen Wu-Shiun Hsieh |
| author_facet | Kuan-Han Huang An-Kuo Chou Suh-Fang Jeng Sharon Ng Chia-Jung Hsieh Mei-Huei Chen Pau-Chung Chen Wu-Shiun Hsieh |
| author_sort | Kuan-Han Huang |
| collection | DOAJ |
| description | This study aimed to investigate the association between cord blood cotinine levels and birth outcome, and to determine whether fetal metabolic gene polymorphisms of glutathione-S-transferase (GST) modulate the effect of environmental tobacco smoke exposure during pregnancy.
Methods: This study included 328 maternal and neonatal pairs. Maternal and cord blood cotinine levels were measured using high performance liquid chromatography. The GST T1 (GSTT1) and GST M1 (GSTM1) polymorphisms were examined using the polymerase chain reaction method. The birth outcomes included birth weight, length, and head circumference, and the risks of having low birth weight and being small for gestational age (SGA).
Results: Cord cotinine level had a dose-dependent impact on the reduction of birth weight, length, and head circumference in newborns. Elevation of cord blood cotinine concentration increased the rate of SGA and low birth weight. The neonates who had GSTT1 or GSTM1 polymorphism were associated with an increased risk of being SGA. A combination of the GSTT1 and GSTM1 null genotype exacerbated the effect of maternal environmental tobacco smoke exposure on SGA more than the presence of either genotype alone (odds ratio=8.90, 95% confidence interval=1.00–79.5).
Conclusion: Cord blood cotinine adversely affects birth outcomes. GSTT1 and GSTM1 null genotype may modify the effect of cord blood cotinine on birth outcomes. |
| first_indexed | 2024-12-12T21:27:58Z |
| format | Article |
| id | doaj.art-2646a4aadead4e9ea8081b295196b61b |
| institution | Directory Open Access Journal |
| issn | 1875-9572 |
| language | English |
| last_indexed | 2024-12-12T21:27:58Z |
| publishDate | 2017-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj.art-2646a4aadead4e9ea8081b295196b61b2022-12-22T00:11:23ZengElsevierPediatrics and Neonatology1875-95722017-08-0158436236910.1016/j.pedneo.2016.08.006The Impacts of Cord Blood Cotinine and Glutathione-S-Transferase Gene Polymorphisms on Birth OutcomeKuan-Han Huang0An-Kuo Chou1Suh-Fang Jeng2Sharon Ng3Chia-Jung Hsieh4Mei-Huei Chen5Pau-Chung Chen6Wu-Shiun Hsieh7Department of Pediatrics, National Taiwan University Children’s Hospital and National Taiwan University, College of Medicine, Taipei, TaiwanDepartment of Pediatrics, National Taiwan University Hospital, Hsinchu Branch, Hsinchu, TaiwanSchool and Graduate Institute of Physical Therapy, National Taiwan University College of Medicine, Taipei, TaiwanDepartment of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, SingaporeDepartment of Public Health, Tzu Chi University, Hualien, TaiwanDepartment of Pediatrics, National Taiwan University Hospital Yunlin Branch, Yunlin, TaiwanInstitute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, TaiwanDepartment of Pediatrics, National Taiwan University Children’s Hospital and National Taiwan University, College of Medicine, Taipei, TaiwanThis study aimed to investigate the association between cord blood cotinine levels and birth outcome, and to determine whether fetal metabolic gene polymorphisms of glutathione-S-transferase (GST) modulate the effect of environmental tobacco smoke exposure during pregnancy. Methods: This study included 328 maternal and neonatal pairs. Maternal and cord blood cotinine levels were measured using high performance liquid chromatography. The GST T1 (GSTT1) and GST M1 (GSTM1) polymorphisms were examined using the polymerase chain reaction method. The birth outcomes included birth weight, length, and head circumference, and the risks of having low birth weight and being small for gestational age (SGA). Results: Cord cotinine level had a dose-dependent impact on the reduction of birth weight, length, and head circumference in newborns. Elevation of cord blood cotinine concentration increased the rate of SGA and low birth weight. The neonates who had GSTT1 or GSTM1 polymorphism were associated with an increased risk of being SGA. A combination of the GSTT1 and GSTM1 null genotype exacerbated the effect of maternal environmental tobacco smoke exposure on SGA more than the presence of either genotype alone (odds ratio=8.90, 95% confidence interval=1.00–79.5). Conclusion: Cord blood cotinine adversely affects birth outcomes. GSTT1 and GSTM1 null genotype may modify the effect of cord blood cotinine on birth outcomes.http://www.sciencedirect.com/science/article/pii/S1875957217300165cotinineenvironmental tobacco smokeglutathione S-transferasenewbornpremature birthsmall for gestational age |
| spellingShingle | Kuan-Han Huang An-Kuo Chou Suh-Fang Jeng Sharon Ng Chia-Jung Hsieh Mei-Huei Chen Pau-Chung Chen Wu-Shiun Hsieh The Impacts of Cord Blood Cotinine and Glutathione-S-Transferase Gene Polymorphisms on Birth Outcome Pediatrics and Neonatology cotinine environmental tobacco smoke glutathione S-transferase newborn premature birth small for gestational age |
| title | The Impacts of Cord Blood Cotinine and Glutathione-S-Transferase Gene Polymorphisms on Birth Outcome |
| title_full | The Impacts of Cord Blood Cotinine and Glutathione-S-Transferase Gene Polymorphisms on Birth Outcome |
| title_fullStr | The Impacts of Cord Blood Cotinine and Glutathione-S-Transferase Gene Polymorphisms on Birth Outcome |
| title_full_unstemmed | The Impacts of Cord Blood Cotinine and Glutathione-S-Transferase Gene Polymorphisms on Birth Outcome |
| title_short | The Impacts of Cord Blood Cotinine and Glutathione-S-Transferase Gene Polymorphisms on Birth Outcome |
| title_sort | impacts of cord blood cotinine and glutathione s transferase gene polymorphisms on birth outcome |
| topic | cotinine environmental tobacco smoke glutathione S-transferase newborn premature birth small for gestational age |
| url | http://www.sciencedirect.com/science/article/pii/S1875957217300165 |
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