Hsa_circ_0016070/micro‐340‐5p Axis Accelerates Pulmonary Arterial Hypertension Progression by Upregulating TWIST1 Transcription Via TCF4/β‐Catenin Complex

Hsa_circ_0016070/micro‐340‐5p Axis Accelerates Pulmonary Arterial Hypertension Progression by Upregulating TWIST1 Transcription Via TCF4/β‐Catenin Complex

Background Hypoxia is considered a major leading cause of pulmonary hypertension (PH). In this study, the roles and molecular mechanism of circ_0016070 in PH were studied. Methods and Results The expression of circ_0016070 in serum samples, human pulmonary artery smooth muscle cells and hypoxia/mono...

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Bibliographic Details
Main Authors: Chun‐Xia Huang, Zhi‐Xin Jiang, Da‐Yong Du, Zhi‐Min Zhang, Yang Liu, Yun‐Tian Li
Format: Article
Language:English
Published: Wiley 2022-07-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
hsa_circ_0016070
miR‐340‐5p
pulmonary hypertension
transcription factor 4
TWIST1
β‐catenin
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.121.024147

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