Transdermal buprenorphine for acute postoperative pain: a systematic review
Abstract Background and objectives: Postoperative pain is still a major concern in several surgical procedures. Multimodal analgesia is best for postoperative pain management; however, opioid therapy is still the main treatment for pain after surgical procedures. Transdermal buprenorphine is a part...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Anestesiologia
2020-09-01
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| Series: | Revista Brasileira de Anestesiologia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0034-70942020000400419&tlng=en |
| _version_ | 1798013911537025024 |
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| author | Felipe Chiodini Machado Gilson Carone Neto Luisa Oliveira de Paiva Tamiris Cristina Soares Ricardo Kenithi Nakamura Leonardo de Freitas Nascimento Camila Sato Campana Lia Alves Martins Mota Lustosa Rachel Andrade Cortez Hazem Adel Ashmawi |
| author_facet | Felipe Chiodini Machado Gilson Carone Neto Luisa Oliveira de Paiva Tamiris Cristina Soares Ricardo Kenithi Nakamura Leonardo de Freitas Nascimento Camila Sato Campana Lia Alves Martins Mota Lustosa Rachel Andrade Cortez Hazem Adel Ashmawi |
| author_sort | Felipe Chiodini Machado |
| collection | DOAJ |
| description | Abstract Background and objectives: Postoperative pain is still a major concern in several surgical procedures. Multimodal analgesia is best for postoperative pain management; however, opioid therapy is still the main treatment for pain after surgical procedures. Transdermal buprenorphine is a partial µ-agonist opioid widely used for chronic pain syndromes, with limited evidence for acute postoperative pain. A systematic review of studies examining transdermal buprenorphine for acute pain management after surgery was conducted. Contents: Data from PubMed, Embase, The Cochrane Central Register of Controlled Trials (CENTRAL), CINAHL via EBSCOhost, and LILACS were reviewed, including randomized clinical trials that evaluated total postoperative pain, postoperative analgesic consumption, drug-related side effects and patient satisfaction with analgesia regimen. Data from nine studies (615 patients) were included in this review. Most studies initiated transdermal buprenorphine use 6 to 48 hours before surgery, maintaining use from 1 to 28 days after the procedure. Most studies showed lower or similar postoperative pain scores, postoperative analgesic consumption and patient satisfaction comparing buprenorphine to placebo, tramadol, celecoxib, flurbiprofen and parecoxib. The incidence of side effects varied between studies, with most showing no increase in drug-related side effects with buprenorphine use, except one study, which compared buprenorphine to oral tramadol, and one to transdermal fentanyl. However, most results were derived from evidence with an overall high or unclear risk of bias. Conclusions: Although more studies are necessary, initial results show that transdermal buprenorphine seems to be an effective and safe opioid choice for management of acute postoperative pain. |
| first_indexed | 2024-04-11T15:09:07Z |
| format | Article |
| id | doaj.art-264b59066ac742c486c8c4d54c46ce96 |
| institution | Directory Open Access Journal |
| issn | 1806-907X |
| language | English |
| last_indexed | 2024-04-11T15:09:07Z |
| publishDate | 2020-09-01 |
| publisher | Sociedade Brasileira de Anestesiologia |
| record_format | Article |
| series | Revista Brasileira de Anestesiologia |
| spelling | doaj.art-264b59066ac742c486c8c4d54c46ce962022-12-22T04:16:41ZengSociedade Brasileira de AnestesiologiaRevista Brasileira de Anestesiologia1806-907X2020-09-0170441942810.1016/j.bjane.2020.06.009Transdermal buprenorphine for acute postoperative pain: a systematic reviewFelipe Chiodini Machadohttps://orcid.org/0000-0003-1615-2597Gilson Carone NetoLuisa Oliveira de PaivaTamiris Cristina SoaresRicardo Kenithi NakamuraLeonardo de Freitas NascimentoCamila Sato CampanaLia Alves Martins Mota LustosaRachel Andrade CortezHazem Adel AshmawiAbstract Background and objectives: Postoperative pain is still a major concern in several surgical procedures. Multimodal analgesia is best for postoperative pain management; however, opioid therapy is still the main treatment for pain after surgical procedures. Transdermal buprenorphine is a partial µ-agonist opioid widely used for chronic pain syndromes, with limited evidence for acute postoperative pain. A systematic review of studies examining transdermal buprenorphine for acute pain management after surgery was conducted. Contents: Data from PubMed, Embase, The Cochrane Central Register of Controlled Trials (CENTRAL), CINAHL via EBSCOhost, and LILACS were reviewed, including randomized clinical trials that evaluated total postoperative pain, postoperative analgesic consumption, drug-related side effects and patient satisfaction with analgesia regimen. Data from nine studies (615 patients) were included in this review. Most studies initiated transdermal buprenorphine use 6 to 48 hours before surgery, maintaining use from 1 to 28 days after the procedure. Most studies showed lower or similar postoperative pain scores, postoperative analgesic consumption and patient satisfaction comparing buprenorphine to placebo, tramadol, celecoxib, flurbiprofen and parecoxib. The incidence of side effects varied between studies, with most showing no increase in drug-related side effects with buprenorphine use, except one study, which compared buprenorphine to oral tramadol, and one to transdermal fentanyl. However, most results were derived from evidence with an overall high or unclear risk of bias. Conclusions: Although more studies are necessary, initial results show that transdermal buprenorphine seems to be an effective and safe opioid choice for management of acute postoperative pain.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0034-70942020000400419&tlng=enBuprenorphineCutaneous administrationTransdermal patchPostoperative painAcute pain |
| spellingShingle | Felipe Chiodini Machado Gilson Carone Neto Luisa Oliveira de Paiva Tamiris Cristina Soares Ricardo Kenithi Nakamura Leonardo de Freitas Nascimento Camila Sato Campana Lia Alves Martins Mota Lustosa Rachel Andrade Cortez Hazem Adel Ashmawi Transdermal buprenorphine for acute postoperative pain: a systematic review Revista Brasileira de Anestesiologia Buprenorphine Cutaneous administration Transdermal patch Postoperative pain Acute pain |
| title | Transdermal buprenorphine for acute postoperative pain: a systematic review |
| title_full | Transdermal buprenorphine for acute postoperative pain: a systematic review |
| title_fullStr | Transdermal buprenorphine for acute postoperative pain: a systematic review |
| title_full_unstemmed | Transdermal buprenorphine for acute postoperative pain: a systematic review |
| title_short | Transdermal buprenorphine for acute postoperative pain: a systematic review |
| title_sort | transdermal buprenorphine for acute postoperative pain a systematic review |
| topic | Buprenorphine Cutaneous administration Transdermal patch Postoperative pain Acute pain |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0034-70942020000400419&tlng=en |
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