Iodo Silanes as Superior Substrates for the Solid Phase Synthesis of Molecularly Imprinted Polymer Nanoparticles
Current state-of-the-art techniques for the solid phase synthesis of molecularly imprinted polymer (MIP) nanoparticles typically rely on amino silanes for the immobilisation of template molecules prior to polymerisation. An investigation into commonly used amino silanes identified a number of proble...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-04-01
|
| Series: | Polymers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4360/14/8/1595 |
| _version_ | 1797409520461283328 |
|---|---|
| author | Stanislav S. Piletsky Alvaro Garcia Cruz Elena Piletska Sergey A. Piletsky Eric O. Aboagye Alan C. Spivey |
| author_facet | Stanislav S. Piletsky Alvaro Garcia Cruz Elena Piletska Sergey A. Piletsky Eric O. Aboagye Alan C. Spivey |
| author_sort | Stanislav S. Piletsky |
| collection | DOAJ |
| description | Current state-of-the-art techniques for the solid phase synthesis of molecularly imprinted polymer (MIP) nanoparticles typically rely on amino silanes for the immobilisation of template molecules prior to polymerisation. An investigation into commonly used amino silanes identified a number of problematic side reactions which negatively affect the purity and affinity of these polymers. Iodo silanes are presented as a superior alternative in a case study describing the synthesis of MIPs against epitopes of a common cancer biomarker, epidermal growth factor receptor (EGFR). The proposed iodo silane outperformed the amino silane by all metrics tested, showing high purity and specificity, and nanomolar affinity for the target peptide. |
| first_indexed | 2024-03-09T04:16:46Z |
| format | Article |
| id | doaj.art-264c765d2ee84b4c848615d0592fb555 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-09T04:16:46Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-264c765d2ee84b4c848615d0592fb5552023-12-03T13:52:49ZengMDPI AGPolymers2073-43602022-04-01148159510.3390/polym14081595Iodo Silanes as Superior Substrates for the Solid Phase Synthesis of Molecularly Imprinted Polymer NanoparticlesStanislav S. Piletsky0Alvaro Garcia Cruz1Elena Piletska2Sergey A. Piletsky3Eric O. Aboagye4Alan C. Spivey5Department of Chemistry, Molecular Sciences Research Hub, White City Campus, Imperial College London, London W12 0BZ, UKSchool of Chemistry, College of Science and Engineering, University of Leicester, Leicester LE1 7RH, UKSchool of Chemistry, College of Science and Engineering, University of Leicester, Leicester LE1 7RH, UKSchool of Chemistry, College of Science and Engineering, University of Leicester, Leicester LE1 7RH, UKDepartment of Surgery and Cancer, Hammersmith Campus, Imperial College, London W12 0NN, UKDepartment of Chemistry, Molecular Sciences Research Hub, White City Campus, Imperial College London, London W12 0BZ, UKCurrent state-of-the-art techniques for the solid phase synthesis of molecularly imprinted polymer (MIP) nanoparticles typically rely on amino silanes for the immobilisation of template molecules prior to polymerisation. An investigation into commonly used amino silanes identified a number of problematic side reactions which negatively affect the purity and affinity of these polymers. Iodo silanes are presented as a superior alternative in a case study describing the synthesis of MIPs against epitopes of a common cancer biomarker, epidermal growth factor receptor (EGFR). The proposed iodo silane outperformed the amino silane by all metrics tested, showing high purity and specificity, and nanomolar affinity for the target peptide.https://www.mdpi.com/2073-4360/14/8/1595molecularly imprinted polymerssolid phase synthesisepidermal growth factor receptor |
| spellingShingle | Stanislav S. Piletsky Alvaro Garcia Cruz Elena Piletska Sergey A. Piletsky Eric O. Aboagye Alan C. Spivey Iodo Silanes as Superior Substrates for the Solid Phase Synthesis of Molecularly Imprinted Polymer Nanoparticles Polymers molecularly imprinted polymers solid phase synthesis epidermal growth factor receptor |
| title | Iodo Silanes as Superior Substrates for the Solid Phase Synthesis of Molecularly Imprinted Polymer Nanoparticles |
| title_full | Iodo Silanes as Superior Substrates for the Solid Phase Synthesis of Molecularly Imprinted Polymer Nanoparticles |
| title_fullStr | Iodo Silanes as Superior Substrates for the Solid Phase Synthesis of Molecularly Imprinted Polymer Nanoparticles |
| title_full_unstemmed | Iodo Silanes as Superior Substrates for the Solid Phase Synthesis of Molecularly Imprinted Polymer Nanoparticles |
| title_short | Iodo Silanes as Superior Substrates for the Solid Phase Synthesis of Molecularly Imprinted Polymer Nanoparticles |
| title_sort | iodo silanes as superior substrates for the solid phase synthesis of molecularly imprinted polymer nanoparticles |
| topic | molecularly imprinted polymers solid phase synthesis epidermal growth factor receptor |
| url | https://www.mdpi.com/2073-4360/14/8/1595 |
| work_keys_str_mv | AT stanislavspiletsky iodosilanesassuperiorsubstratesforthesolidphasesynthesisofmolecularlyimprintedpolymernanoparticles AT alvarogarciacruz iodosilanesassuperiorsubstratesforthesolidphasesynthesisofmolecularlyimprintedpolymernanoparticles AT elenapiletska iodosilanesassuperiorsubstratesforthesolidphasesynthesisofmolecularlyimprintedpolymernanoparticles AT sergeyapiletsky iodosilanesassuperiorsubstratesforthesolidphasesynthesisofmolecularlyimprintedpolymernanoparticles AT ericoaboagye iodosilanesassuperiorsubstratesforthesolidphasesynthesisofmolecularlyimprintedpolymernanoparticles AT alancspivey iodosilanesassuperiorsubstratesforthesolidphasesynthesisofmolecularlyimprintedpolymernanoparticles |