Preparation and Characterization of Semi-IPN Cryogels Based on Polyacrylamide and Poly(<i>N</i>,<i>N</i>-dimethylaminoethyl methacrylate); Functionalization of Carrier with Monochlorotriazinyl-β-cyclodextrin and Release Kinetics of Curcumin
Curcumin (CCM) is a natural hydrophobic polyphenol known for its numerous applications in the food industry as a colorant or jelly stabilizer, and in the pharmaceutical industry due to its anti-inflammatory, antibacterial, antioxidant, anti-cancer, and anti-Alzheimer properties. However, the large a...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-11-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/26/22/6975 |
| _version_ | 1797509136831741952 |
|---|---|
| author | Ecaterina Stela Dragan Maria Valentina Dinu Claudiu Augustin Ghiorghita Maria Marinela Lazar Florica Doroftei |
| author_facet | Ecaterina Stela Dragan Maria Valentina Dinu Claudiu Augustin Ghiorghita Maria Marinela Lazar Florica Doroftei |
| author_sort | Ecaterina Stela Dragan |
| collection | DOAJ |
| description | Curcumin (CCM) is a natural hydrophobic polyphenol known for its numerous applications in the food industry as a colorant or jelly stabilizer, and in the pharmaceutical industry due to its anti-inflammatory, antibacterial, antioxidant, anti-cancer, and anti-Alzheimer properties. However, the large application of CCM is limited by its poor solubility in water and low stability. To enhance the bioavailability of CCM, and to protect it against the external degradation agents, a novel strategy, which consists in the preparation of semi-interpenetrating polymer networks, (s-IPNs) based on poly(<i>N</i>,<i>N</i>-dimethylaminoethyl methacrylate) entrapped in poly(acrylamide) networks, by a cryogelation technique, was developed in this work. All s-IPN cryogels were characterized by SEM, EDX, FTIR, and swelling at equilibrium as a function of pH. Functionalization of semi-IPN cryogel with monochlorotriazinyl-β-cyclodextrin (MCT-β-CD) led to IPN cryogel. The release profile of CCM from the composite cryogels was investigated at 37 °C, in pH 3. It was found that the cumulative release increased with the increase of the carrier hydrophobicity, as a result of increasing the cross-linking degree, the content and the molar mass of PDMAEMA. Fitting Higuchi, Korsmeyer–Peppas, and first order kinetic models on the CCM release profiles indicated the diffusion as the main driving force of drug release from the composite cryogels. |
| first_indexed | 2024-03-10T05:13:31Z |
| format | Article |
| id | doaj.art-264d0236e9984a6fb88b57da4309f778 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T05:13:31Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-264d0236e9984a6fb88b57da4309f7782023-11-23T00:36:39ZengMDPI AGMolecules1420-30492021-11-012622697510.3390/molecules26226975Preparation and Characterization of Semi-IPN Cryogels Based on Polyacrylamide and Poly(<i>N</i>,<i>N</i>-dimethylaminoethyl methacrylate); Functionalization of Carrier with Monochlorotriazinyl-β-cyclodextrin and Release Kinetics of CurcuminEcaterina Stela Dragan0Maria Valentina Dinu1Claudiu Augustin Ghiorghita2Maria Marinela Lazar3Florica Doroftei4Department of Functional Polymers, “Petru Poni” Institute of Macromolecular Chemistry, 700487 Iași, RomaniaDepartment of Functional Polymers, “Petru Poni” Institute of Macromolecular Chemistry, 700487 Iași, RomaniaDepartment of Functional Polymers, “Petru Poni” Institute of Macromolecular Chemistry, 700487 Iași, RomaniaDepartment of Functional Polymers, “Petru Poni” Institute of Macromolecular Chemistry, 700487 Iași, RomaniaDepartment of Functional Polymers, “Petru Poni” Institute of Macromolecular Chemistry, 700487 Iași, RomaniaCurcumin (CCM) is a natural hydrophobic polyphenol known for its numerous applications in the food industry as a colorant or jelly stabilizer, and in the pharmaceutical industry due to its anti-inflammatory, antibacterial, antioxidant, anti-cancer, and anti-Alzheimer properties. However, the large application of CCM is limited by its poor solubility in water and low stability. To enhance the bioavailability of CCM, and to protect it against the external degradation agents, a novel strategy, which consists in the preparation of semi-interpenetrating polymer networks, (s-IPNs) based on poly(<i>N</i>,<i>N</i>-dimethylaminoethyl methacrylate) entrapped in poly(acrylamide) networks, by a cryogelation technique, was developed in this work. All s-IPN cryogels were characterized by SEM, EDX, FTIR, and swelling at equilibrium as a function of pH. Functionalization of semi-IPN cryogel with monochlorotriazinyl-β-cyclodextrin (MCT-β-CD) led to IPN cryogel. The release profile of CCM from the composite cryogels was investigated at 37 °C, in pH 3. It was found that the cumulative release increased with the increase of the carrier hydrophobicity, as a result of increasing the cross-linking degree, the content and the molar mass of PDMAEMA. Fitting Higuchi, Korsmeyer–Peppas, and first order kinetic models on the CCM release profiles indicated the diffusion as the main driving force of drug release from the composite cryogels.https://www.mdpi.com/1420-3049/26/22/6975cryogelpoly(acrylamide)poly(<i>N</i>,<i>N</i>-dimethylaminoethylmethacrylate)monochlorotriazinyl-β-cyclodextrincurcumin |
| spellingShingle | Ecaterina Stela Dragan Maria Valentina Dinu Claudiu Augustin Ghiorghita Maria Marinela Lazar Florica Doroftei Preparation and Characterization of Semi-IPN Cryogels Based on Polyacrylamide and Poly(<i>N</i>,<i>N</i>-dimethylaminoethyl methacrylate); Functionalization of Carrier with Monochlorotriazinyl-β-cyclodextrin and Release Kinetics of Curcumin Molecules cryogel poly(acrylamide) poly(<i>N</i>,<i>N</i>-dimethylaminoethylmethacrylate) monochlorotriazinyl-β-cyclodextrin curcumin |
| title | Preparation and Characterization of Semi-IPN Cryogels Based on Polyacrylamide and Poly(<i>N</i>,<i>N</i>-dimethylaminoethyl methacrylate); Functionalization of Carrier with Monochlorotriazinyl-β-cyclodextrin and Release Kinetics of Curcumin |
| title_full | Preparation and Characterization of Semi-IPN Cryogels Based on Polyacrylamide and Poly(<i>N</i>,<i>N</i>-dimethylaminoethyl methacrylate); Functionalization of Carrier with Monochlorotriazinyl-β-cyclodextrin and Release Kinetics of Curcumin |
| title_fullStr | Preparation and Characterization of Semi-IPN Cryogels Based on Polyacrylamide and Poly(<i>N</i>,<i>N</i>-dimethylaminoethyl methacrylate); Functionalization of Carrier with Monochlorotriazinyl-β-cyclodextrin and Release Kinetics of Curcumin |
| title_full_unstemmed | Preparation and Characterization of Semi-IPN Cryogels Based on Polyacrylamide and Poly(<i>N</i>,<i>N</i>-dimethylaminoethyl methacrylate); Functionalization of Carrier with Monochlorotriazinyl-β-cyclodextrin and Release Kinetics of Curcumin |
| title_short | Preparation and Characterization of Semi-IPN Cryogels Based on Polyacrylamide and Poly(<i>N</i>,<i>N</i>-dimethylaminoethyl methacrylate); Functionalization of Carrier with Monochlorotriazinyl-β-cyclodextrin and Release Kinetics of Curcumin |
| title_sort | preparation and characterization of semi ipn cryogels based on polyacrylamide and poly i n i i n i dimethylaminoethyl methacrylate functionalization of carrier with monochlorotriazinyl β cyclodextrin and release kinetics of curcumin |
| topic | cryogel poly(acrylamide) poly(<i>N</i>,<i>N</i>-dimethylaminoethylmethacrylate) monochlorotriazinyl-β-cyclodextrin curcumin |
| url | https://www.mdpi.com/1420-3049/26/22/6975 |
| work_keys_str_mv | AT ecaterinasteladragan preparationandcharacterizationofsemiipncryogelsbasedonpolyacrylamideandpolyiniinidimethylaminoethylmethacrylatefunctionalizationofcarrierwithmonochlorotriazinylbcyclodextrinandreleasekineticsofcurcumin AT mariavalentinadinu preparationandcharacterizationofsemiipncryogelsbasedonpolyacrylamideandpolyiniinidimethylaminoethylmethacrylatefunctionalizationofcarrierwithmonochlorotriazinylbcyclodextrinandreleasekineticsofcurcumin AT claudiuaugustinghiorghita preparationandcharacterizationofsemiipncryogelsbasedonpolyacrylamideandpolyiniinidimethylaminoethylmethacrylatefunctionalizationofcarrierwithmonochlorotriazinylbcyclodextrinandreleasekineticsofcurcumin AT mariamarinelalazar preparationandcharacterizationofsemiipncryogelsbasedonpolyacrylamideandpolyiniinidimethylaminoethylmethacrylatefunctionalizationofcarrierwithmonochlorotriazinylbcyclodextrinandreleasekineticsofcurcumin AT floricadoroftei preparationandcharacterizationofsemiipncryogelsbasedonpolyacrylamideandpolyiniinidimethylaminoethylmethacrylatefunctionalizationofcarrierwithmonochlorotriazinylbcyclodextrinandreleasekineticsofcurcumin |