Structural similarities between SARS-CoV2 3CLpro and other viral proteases suggest potential lead molecules for developing broad spectrum antivirals

Structural similarities between SARS-CoV2 3CLpro and other viral proteases suggest potential lead molecules for developing broad spectrum antivirals

Considering the significant impact of the recent COVID-19 outbreak, development of broad-spectrum antivirals is a high priority goal to prevent future global pandemics. Antiviral development processes generally emphasize targeting a specific protein from a particular virus. However, some antiviral a...

Full description

Bibliographic Details
Main Authors: Khushboo Bafna, Christopher L. Cioffi, Robert M. Krug, Gaetano T. Montelione
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Chemistry
Subjects:
COVID-19
drug discovery
structural bioinformatics
virtual docking
structure based dendrograms
topology diagrams
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2022.948553/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2022.948553/full

Similar Items