Defining the conformational features of anchorless, poorly neuroinvasive prions.

Defining the conformational features of anchorless, poorly neuroinvasive prions.

Infectious prions cause diverse clinical signs and form an extraordinary range of structures, from amorphous aggregates to fibrils. How the conformation of a prion dictates the disease phenotype remains unclear. Mice expressing GPI-anchorless or GPI-anchored prion protein exposed to the same infecti...

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Bibliographic Details
Main Authors: Cyrus Bett, Tim D Kurt, Melanie Lucero, Margarita Trejo, Annemieke J Rozemuller, Qingzhong Kong, K Peter R Nilsson, Eliezer Masliah, Michael B Oldstone, Christina J Sigurdson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3630170?pdf=render

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