Nano‐enabled Tumor Systematic Energy Exhaustion via Zinc (II) Interference Mediated Glycolysis Inhibition and Specific GLUT1 Depletion

Nano‐enabled Tumor Systematic Energy Exhaustion via Zinc (II) Interference Mediated Glycolysis Inhibition and Specific GLUT1 Depletion

Abstract Despite the promise of tumor starvation therapies, they are often associated with nonspecific and incomplete energy blockade. Here, a novel paradigm of starvation therapy is proposed to synergize the “Zn2+ interference”‐mediated glycolysis inhibition and Zn2+‐activating GLUT1 (Glucose trans...

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Bibliographic Details
Main Authors: Sixuan Wu, Kaixiang Zhang, Yan Liang, Yongbin Wei, Jingyi An, Yifei Wang, Jiali Yang, Hongling Zhang, Zhenzhong Zhang, Junjie Liu, Jinjin Shi
Format: Article
Language:English
Published: Wiley 2022-03-01
Series:Advanced Science
Subjects:
GLUT1 depletion
glycolysis inhibition
starvation therapy
systematic energy exhaustion
zinc (II) interference
Online Access:https://doi.org/10.1002/advs.202103534

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