Regenerative Potential of Hydroxyapatite-Based Ceramic Biomaterial on Mandibular Cortical Bone: An <i>In Vivo</i> Study
Reconstruction of bone defects and maintaining the continuity of the mandible is still a challenge in the maxillofacial surgery. Nowadays, the biomedical research within bone defect treatment is focussed on the therapy of using innovative biomaterials with specific characteristics consisting of the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/3/877 |
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| author | Katarína Vdoviaková Andrej Jenca Andrej Jenca Ján Danko Lenka Kresáková Veronika Simaiová Peter Reichel Pavol Rusnák Jozef Pribula Marko Vrzgula Sarah J. Askin Maria Giretová Jaroslav Briancin Lubomír Medvecký |
| author_facet | Katarína Vdoviaková Andrej Jenca Andrej Jenca Ján Danko Lenka Kresáková Veronika Simaiová Peter Reichel Pavol Rusnák Jozef Pribula Marko Vrzgula Sarah J. Askin Maria Giretová Jaroslav Briancin Lubomír Medvecký |
| author_sort | Katarína Vdoviaková |
| collection | DOAJ |
| description | Reconstruction of bone defects and maintaining the continuity of the mandible is still a challenge in the maxillofacial surgery. Nowadays, the biomedical research within bone defect treatment is focussed on the therapy of using innovative biomaterials with specific characteristics consisting of the body’s own substances. Hydroxyapatite ceramic scaffolds have fully acceptable phase compositions, microstructures and compressive strengths for their use in regenerative medicine. The innovative hydroxyapatite ceramics used by us were prepared using the tape-casting method, which allows variation in the shape of samples after packing hydroxyapatite paste to 3D-printed plastic form. The purpose of our qualitative study was to evaluate the regenerative potential of the innovative ceramic biomaterial prepared using this method in the therapy of the cortical bone of the lower jaw in four mature pigs. The mandible bone defects were evaluated after different periods of time (after 3, 4, 5 and 6 months) and compared with the control sample (healthy cortical bone from the opposite side of the mandible). The results of the morphological, clinical and radiological investigation and hardness examination confirmed the positive regenerative potential of ceramic implants after treatment of the mandible bone defects in the porcine mandible model. |
| first_indexed | 2024-03-11T06:53:15Z |
| format | Article |
| id | doaj.art-26540d21d12d4ace80d56b3318d0c356 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T06:53:15Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-26540d21d12d4ace80d56b3318d0c3562023-11-17T09:46:56ZengMDPI AGBiomedicines2227-90592023-03-0111387710.3390/biomedicines11030877Regenerative Potential of Hydroxyapatite-Based Ceramic Biomaterial on Mandibular Cortical Bone: An <i>In Vivo</i> StudyKatarína Vdoviaková0Andrej Jenca1Andrej Jenca2Ján Danko3Lenka Kresáková4Veronika Simaiová5Peter Reichel6Pavol Rusnák7Jozef Pribula8Marko Vrzgula9Sarah J. Askin10Maria Giretová11Jaroslav Briancin12Lubomír Medvecký13Department of Morphological Disciplines, University of Veterinary Medicine and Pharmacy in Kosice, Komenskeho 73, 041 81 Kosice, SlovakiaSolmea s.r.o., Bacikova 7, 040 01 Kosice, SlovakiaSolmea s.r.o., Bacikova 7, 040 01 Kosice, SlovakiaDepartment of Morphological Disciplines, University of Veterinary Medicine and Pharmacy in Kosice, Komenskeho 73, 041 81 Kosice, SlovakiaDepartment of Morphological Disciplines, University of Veterinary Medicine and Pharmacy in Kosice, Komenskeho 73, 041 81 Kosice, SlovakiaDepartment of Morphological Disciplines, University of Veterinary Medicine and Pharmacy in Kosice, Komenskeho 73, 041 81 Kosice, SlovakiaSvine Clinic, University of Veterinary Medicine and Pharmacy in Kosice, Komenskeho 73, 041 81 Kosice, SlovakiaHospital AGEL Kosice-Saca, Lucna 57, 040 15 Kosice-Saca, SlovakiaEducational, Scientific and Research Institute AGEL, Palisady, 743/56, 811 06 Bratislava, SlovakiaDepartment of Anatomy, Pavol Jozef Safarik University in Kosice, Srobarova 2, 041 80 Kosice, SlovakiaAshmore Veterinary Centre, 59 High Street, Geen Street Green, Orpington BR6 6BQ, UKDivision of Functional and Hybrid Systems, Institute of Materials Research of SAS, Watsonova 47, 040 01 Kosice, SlovakiaInstitute of Geotechnics of SAS, Watsonova 45, 040 01 Kosice, SlovakiaDivision of Functional and Hybrid Systems, Institute of Materials Research of SAS, Watsonova 47, 040 01 Kosice, SlovakiaReconstruction of bone defects and maintaining the continuity of the mandible is still a challenge in the maxillofacial surgery. Nowadays, the biomedical research within bone defect treatment is focussed on the therapy of using innovative biomaterials with specific characteristics consisting of the body’s own substances. Hydroxyapatite ceramic scaffolds have fully acceptable phase compositions, microstructures and compressive strengths for their use in regenerative medicine. The innovative hydroxyapatite ceramics used by us were prepared using the tape-casting method, which allows variation in the shape of samples after packing hydroxyapatite paste to 3D-printed plastic form. The purpose of our qualitative study was to evaluate the regenerative potential of the innovative ceramic biomaterial prepared using this method in the therapy of the cortical bone of the lower jaw in four mature pigs. The mandible bone defects were evaluated after different periods of time (after 3, 4, 5 and 6 months) and compared with the control sample (healthy cortical bone from the opposite side of the mandible). The results of the morphological, clinical and radiological investigation and hardness examination confirmed the positive regenerative potential of ceramic implants after treatment of the mandible bone defects in the porcine mandible model.https://www.mdpi.com/2227-9059/11/3/877biomaterialbone defectlower jawceramic implantsmandiblepig |
| spellingShingle | Katarína Vdoviaková Andrej Jenca Andrej Jenca Ján Danko Lenka Kresáková Veronika Simaiová Peter Reichel Pavol Rusnák Jozef Pribula Marko Vrzgula Sarah J. Askin Maria Giretová Jaroslav Briancin Lubomír Medvecký Regenerative Potential of Hydroxyapatite-Based Ceramic Biomaterial on Mandibular Cortical Bone: An <i>In Vivo</i> Study Biomedicines biomaterial bone defect lower jaw ceramic implants mandible pig |
| title | Regenerative Potential of Hydroxyapatite-Based Ceramic Biomaterial on Mandibular Cortical Bone: An <i>In Vivo</i> Study |
| title_full | Regenerative Potential of Hydroxyapatite-Based Ceramic Biomaterial on Mandibular Cortical Bone: An <i>In Vivo</i> Study |
| title_fullStr | Regenerative Potential of Hydroxyapatite-Based Ceramic Biomaterial on Mandibular Cortical Bone: An <i>In Vivo</i> Study |
| title_full_unstemmed | Regenerative Potential of Hydroxyapatite-Based Ceramic Biomaterial on Mandibular Cortical Bone: An <i>In Vivo</i> Study |
| title_short | Regenerative Potential of Hydroxyapatite-Based Ceramic Biomaterial on Mandibular Cortical Bone: An <i>In Vivo</i> Study |
| title_sort | regenerative potential of hydroxyapatite based ceramic biomaterial on mandibular cortical bone an i in vivo i study |
| topic | biomaterial bone defect lower jaw ceramic implants mandible pig |
| url | https://www.mdpi.com/2227-9059/11/3/877 |
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