Composition, Biogenesis, and Role of Exosomes in Tumor Development
The role of exosomes and their mechanism of action at the tumor site have received increasing attention. These microvesicles are produced by a wide range of cells including mesenchymal stem cells (MSCs) and immune cells. In particular, tumor cells release remarkable amounts of exosomes which spread...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Hindawi Limited
2022-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2022/8392509 |
| _version_ | 1797995013463867392 |
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| author | Leila Moeinzadeh Iman Razeghian-Jahromi Zeinab Zarei-Behjani Zohreh Bagheri Mahboobeh Razmkhah |
| author_facet | Leila Moeinzadeh Iman Razeghian-Jahromi Zeinab Zarei-Behjani Zohreh Bagheri Mahboobeh Razmkhah |
| author_sort | Leila Moeinzadeh |
| collection | DOAJ |
| description | The role of exosomes and their mechanism of action at the tumor site have received increasing attention. These microvesicles are produced by a wide range of cells including mesenchymal stem cells (MSCs) and immune cells. In particular, tumor cells release remarkable amounts of exosomes which spread to distant organs through the blood and enhance the possibility of tumor metastasis. In spite of results on tumor promoting properties, there are reports demonstrating the tumor inhibiting effects of exosomes depending on the type of the tumor and cell source. This review aims to have a comprehensive appraisal on the biogenesis, composition, and isolation of exosomes and then highlights the current knowledge of their role in cancer progression or inhibition by special focusing on MSC’s exosomes (MSC-EXOs). |
| first_indexed | 2024-04-11T09:53:47Z |
| format | Article |
| id | doaj.art-265560a20e494979b3aa55e5df9e90f3 |
| institution | Directory Open Access Journal |
| issn | 1687-9678 |
| language | English |
| last_indexed | 2024-04-11T09:53:47Z |
| publishDate | 2022-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj.art-265560a20e494979b3aa55e5df9e90f32022-12-22T04:30:41ZengHindawi LimitedStem Cells International1687-96782022-01-01202210.1155/2022/8392509Composition, Biogenesis, and Role of Exosomes in Tumor DevelopmentLeila Moeinzadeh0Iman Razeghian-Jahromi1Zeinab Zarei-Behjani2Zohreh Bagheri3Mahboobeh Razmkhah4Department of Tissue Engineering and Applied Cell SciencesCardiovascular Research CenterDepartment of Tissue Engineering and Applied Cell SciencesShiraz Institute for Cancer ResearchDepartment of Tissue Engineering and Applied Cell SciencesThe role of exosomes and their mechanism of action at the tumor site have received increasing attention. These microvesicles are produced by a wide range of cells including mesenchymal stem cells (MSCs) and immune cells. In particular, tumor cells release remarkable amounts of exosomes which spread to distant organs through the blood and enhance the possibility of tumor metastasis. In spite of results on tumor promoting properties, there are reports demonstrating the tumor inhibiting effects of exosomes depending on the type of the tumor and cell source. This review aims to have a comprehensive appraisal on the biogenesis, composition, and isolation of exosomes and then highlights the current knowledge of their role in cancer progression or inhibition by special focusing on MSC’s exosomes (MSC-EXOs).http://dx.doi.org/10.1155/2022/8392509 |
| spellingShingle | Leila Moeinzadeh Iman Razeghian-Jahromi Zeinab Zarei-Behjani Zohreh Bagheri Mahboobeh Razmkhah Composition, Biogenesis, and Role of Exosomes in Tumor Development Stem Cells International |
| title | Composition, Biogenesis, and Role of Exosomes in Tumor Development |
| title_full | Composition, Biogenesis, and Role of Exosomes in Tumor Development |
| title_fullStr | Composition, Biogenesis, and Role of Exosomes in Tumor Development |
| title_full_unstemmed | Composition, Biogenesis, and Role of Exosomes in Tumor Development |
| title_short | Composition, Biogenesis, and Role of Exosomes in Tumor Development |
| title_sort | composition biogenesis and role of exosomes in tumor development |
| url | http://dx.doi.org/10.1155/2022/8392509 |
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