Angiotensin-Converting Enzyme 2 Gene Expression in Breast Tissue
Objective:Binding to angiotensin-converting enzyme 2 (ACE2) receptor is a critical step for severe acute respiratory syndrome coronavirus 2 (SARSCoV- 2) to mediate its entry into target cells. ACE2 is expressed in many human tissues, including the lungs. However, no research has demonstrated that SA...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2021-04-01
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| Series: | European Journal of Breast Health |
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| Online Access: |
http://www.eurjbreasthealth.com/archives/archive-detail/article-preview/iangiotensin-converting-enzyme-2-i-gene-expression/47119
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| _version_ | 1797924169332031488 |
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| author | Sammy Al-Benna |
| author_facet | Sammy Al-Benna |
| author_sort | Sammy Al-Benna |
| collection | DOAJ |
| description | Objective:Binding to angiotensin-converting enzyme 2 (ACE2) receptor is a critical step for severe acute respiratory syndrome coronavirus 2 (SARSCoV- 2) to mediate its entry into target cells. ACE2 is expressed in many human tissues, including the lungs. However, no research has demonstrated that SARS-CoV-2 can infect human breast tissue. This study aimed to investigate ACE2 gene expression in human breast tissue using a public database.Materials and Methods:A search of a public gene expression database was performed to investigate ACE2 gene expression in in human breast tissue.Results:The gene expression profile demonstrated that ACE2 gene expression was higher in human breast tissue than human lung tissue.Conclusion:Our knowledge about coronavirus disease-2019 (COVID-19) is expanding rapidly. Clinicians are eager for vetted information regarding all aspects of this new illness, and this study demonstrates that the level of ACE2 expression in human breast tissue is higher than that in the lung tissue, a major target tissue affected by SARS-CoV-2 infection. This finding strongly suggests that SARS-CoV-2 infection causes breast pathology. |
| first_indexed | 2024-04-10T14:57:19Z |
| format | Article |
| id | doaj.art-26564a8af6f3406b96917c2350c6703a |
| institution | Directory Open Access Journal |
| issn | 2587-0831 |
| language | English |
| last_indexed | 2024-04-10T14:57:19Z |
| publishDate | 2021-04-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | European Journal of Breast Health |
| spelling | doaj.art-26564a8af6f3406b96917c2350c6703a2023-02-15T16:07:17ZengGalenos Publishing HouseEuropean Journal of Breast Health2587-08312021-04-0117211211510.4274/ejbh.galenos.2021.600713049054Angiotensin-Converting Enzyme 2 Gene Expression in Breast TissueSammy Al-Benna0 Division of Plastic and Reconstructive Surgery, Stellenbosch University and Tygerberg Academic Hospital, Cape Town, South Africa Objective:Binding to angiotensin-converting enzyme 2 (ACE2) receptor is a critical step for severe acute respiratory syndrome coronavirus 2 (SARSCoV- 2) to mediate its entry into target cells. ACE2 is expressed in many human tissues, including the lungs. However, no research has demonstrated that SARS-CoV-2 can infect human breast tissue. This study aimed to investigate ACE2 gene expression in human breast tissue using a public database.Materials and Methods:A search of a public gene expression database was performed to investigate ACE2 gene expression in in human breast tissue.Results:The gene expression profile demonstrated that ACE2 gene expression was higher in human breast tissue than human lung tissue.Conclusion:Our knowledge about coronavirus disease-2019 (COVID-19) is expanding rapidly. Clinicians are eager for vetted information regarding all aspects of this new illness, and this study demonstrates that the level of ACE2 expression in human breast tissue is higher than that in the lung tissue, a major target tissue affected by SARS-CoV-2 infection. This finding strongly suggests that SARS-CoV-2 infection causes breast pathology. http://www.eurjbreasthealth.com/archives/archive-detail/article-preview/iangiotensin-converting-enzyme-2-i-gene-expression/47119 breastangiotensin converting enzyme 2gene expressioncoronavirussevere acute respiratory syndrome coronavirus 2covid-19 |
| spellingShingle | Sammy Al-Benna Angiotensin-Converting Enzyme 2 Gene Expression in Breast Tissue European Journal of Breast Health breast angiotensin converting enzyme 2 gene expression coronavirus severe acute respiratory syndrome coronavirus 2 covid-19 |
| title | Angiotensin-Converting Enzyme 2 Gene Expression in Breast Tissue |
| title_full | Angiotensin-Converting Enzyme 2 Gene Expression in Breast Tissue |
| title_fullStr | Angiotensin-Converting Enzyme 2 Gene Expression in Breast Tissue |
| title_full_unstemmed | Angiotensin-Converting Enzyme 2 Gene Expression in Breast Tissue |
| title_short | Angiotensin-Converting Enzyme 2 Gene Expression in Breast Tissue |
| title_sort | angiotensin converting enzyme 2 gene expression in breast tissue |
| topic | breast angiotensin converting enzyme 2 gene expression coronavirus severe acute respiratory syndrome coronavirus 2 covid-19 |
| url |
http://www.eurjbreasthealth.com/archives/archive-detail/article-preview/iangiotensin-converting-enzyme-2-i-gene-expression/47119
|
| work_keys_str_mv | AT sammyalbenna angiotensinconvertingenzyme2geneexpressioninbreasttissue |