Structure-Functional Activity Relationship of β-Glucans From the Perspective of Immunomodulation: A Mini-Review
β-Glucans are a heterogeneous group of glucose polymers with a common structure comprising a main chain of β-(1,3) and/or β-(1,4)-glucopyranosyl units, along with side chains with various branches and lengths. β-Glucans initiate immune responses via immune cells, which become activated by the bindin...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-04-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2020.00658/full |
| _version_ | 1811223898247659520 |
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| author | Biao Han Kartik Baruah Kartik Baruah Eric Cox Daisy Vanrompay Peter Bossier |
| author_facet | Biao Han Kartik Baruah Kartik Baruah Eric Cox Daisy Vanrompay Peter Bossier |
| author_sort | Biao Han |
| collection | DOAJ |
| description | β-Glucans are a heterogeneous group of glucose polymers with a common structure comprising a main chain of β-(1,3) and/or β-(1,4)-glucopyranosyl units, along with side chains with various branches and lengths. β-Glucans initiate immune responses via immune cells, which become activated by the binding of the polymer to specific receptors. However, β-glucans from different sources also differ in their structure, conformation, physical properties, binding affinity to receptors, and thus biological functions. The mechanisms behind this are not fully understood. This mini-review provides a comprehensive and up-to-date commentary on the relationship between β-glucans' structure and function in relation to their use for immunomodulation. |
| first_indexed | 2024-04-12T08:40:25Z |
| format | Article |
| id | doaj.art-2657013cb17a4b7e8e37e18e05eea496 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-12T08:40:25Z |
| publishDate | 2020-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-2657013cb17a4b7e8e37e18e05eea4962022-12-22T03:39:54ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-04-011110.3389/fimmu.2020.00658521871Structure-Functional Activity Relationship of β-Glucans From the Perspective of Immunomodulation: A Mini-ReviewBiao Han0Kartik Baruah1Kartik Baruah2Eric Cox3Daisy Vanrompay4Peter Bossier5Laboratory of Aquaculture & Artemia Reference Center, Faculty of Bioscience Engineering, Ghent University, Gent, BelgiumLaboratory of Aquaculture & Artemia Reference Center, Faculty of Bioscience Engineering, Ghent University, Gent, BelgiumDepartment of Animal Nutrition and Management, Faculty of Veterinary Medicine and Animal Sciences, Swedish University of Agricultural Sciences, Uppsala, SwedenLaboratory of Immunology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, BelgiumLaboratory of Immunology and Animal Biotechnology, Faculty of Bioscience Engineering, Ghent University, Gent, BelgiumLaboratory of Aquaculture & Artemia Reference Center, Faculty of Bioscience Engineering, Ghent University, Gent, Belgiumβ-Glucans are a heterogeneous group of glucose polymers with a common structure comprising a main chain of β-(1,3) and/or β-(1,4)-glucopyranosyl units, along with side chains with various branches and lengths. β-Glucans initiate immune responses via immune cells, which become activated by the binding of the polymer to specific receptors. However, β-glucans from different sources also differ in their structure, conformation, physical properties, binding affinity to receptors, and thus biological functions. The mechanisms behind this are not fully understood. This mini-review provides a comprehensive and up-to-date commentary on the relationship between β-glucans' structure and function in relation to their use for immunomodulation.https://www.frontiersin.org/article/10.3389/fimmu.2020.00658/fullβ-glucansstructure-function relationshipimmunomodulationmolecular structuremolecular weightsolubility |
| spellingShingle | Biao Han Kartik Baruah Kartik Baruah Eric Cox Daisy Vanrompay Peter Bossier Structure-Functional Activity Relationship of β-Glucans From the Perspective of Immunomodulation: A Mini-Review Frontiers in Immunology β-glucans structure-function relationship immunomodulation molecular structure molecular weight solubility |
| title | Structure-Functional Activity Relationship of β-Glucans From the Perspective of Immunomodulation: A Mini-Review |
| title_full | Structure-Functional Activity Relationship of β-Glucans From the Perspective of Immunomodulation: A Mini-Review |
| title_fullStr | Structure-Functional Activity Relationship of β-Glucans From the Perspective of Immunomodulation: A Mini-Review |
| title_full_unstemmed | Structure-Functional Activity Relationship of β-Glucans From the Perspective of Immunomodulation: A Mini-Review |
| title_short | Structure-Functional Activity Relationship of β-Glucans From the Perspective of Immunomodulation: A Mini-Review |
| title_sort | structure functional activity relationship of β glucans from the perspective of immunomodulation a mini review |
| topic | β-glucans structure-function relationship immunomodulation molecular structure molecular weight solubility |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2020.00658/full |
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