Estrogen receptor targeting with genistein radiolabeled Technetium-99m as radiotracer of breast cancer: Its optimization, characterization, and predicting stability constants by DFT calculation

Estrogen receptor targeting with genistein radiolabeled Technetium-99m as radiotracer of breast cancer: Its optimization, characterization, and predicting stability constants by DFT calculation

Objective: Genistein is an isoflavone molecule with a high affinity for estrogen receptors (ER), which could lead to the mechanism of selective estrogen receptor modulators (SERMs) in breast cancer. Genistein labeling with technetium-99m can be a new promising strategy for diagnostic breast cancer....

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Bibliographic Details
Main Authors: Danni Ramdhani, Nita Listiani, Maula Eka Sriyani, Eva Maria W, Hiroshi Watabe, Resmi Mustarichie, Sri Agung Fitri Kusuma, Regaputra S. Janitra
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Heliyon
Subjects:
Breast cancer
Estrogen receptors β
Genistein
Technetium-99 m
Physicochemical properties
Thermodynamic stability
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023003766

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