Trends of Chitosan Based Delivery Systems in Neuroregeneration and Functional Recovery in Spinal Cord Injuries
Spinal cord injury (SCI) is one of the most complicated nervous system injuries with challenging treatment and recovery. Regenerative biomaterials such as chitosan are being reported for their wide use in filling the cavities, deliver curative drugs, and also provide adsorption sites for transplante...
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| Format: | Article |
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MDPI AG
2021-06-01
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| Series: | Polysaccharides |
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| Online Access: | https://www.mdpi.com/2673-4176/2/2/31 |
| _version_ | 1797520943868805120 |
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| author | Mallesh Kurakula Shashank Gorityala Devang B. Patel Pratap Basim Bhaumik Patel Saurabh Kumar Jha |
| author_facet | Mallesh Kurakula Shashank Gorityala Devang B. Patel Pratap Basim Bhaumik Patel Saurabh Kumar Jha |
| author_sort | Mallesh Kurakula |
| collection | DOAJ |
| description | Spinal cord injury (SCI) is one of the most complicated nervous system injuries with challenging treatment and recovery. Regenerative biomaterials such as chitosan are being reported for their wide use in filling the cavities, deliver curative drugs, and also provide adsorption sites for transplanted stem cells. Biomaterial scaffolds utilizing chitosan have shown certain therapeutic effects on spinal cord injury repair with some limitations. Chitosan-based delivery in stem cell transplantation is another strategy that has shown decent success. Stem cells can be directed to differentiate into neurons or glia in vitro. Stem cell-based therapy, biopolymer chitosan delivery strategies, and scaffold-based therapeutic strategies have been advancing as a combinatorial approach for spinal cord injury repair. In this review, we summarize the recent progress in the treatment strategies of SCI due to the use of bioactivity of chitosan-based drug delivery systems. An emphasis on the role of chitosan in neural regeneration has also been highlighted. |
| first_indexed | 2024-03-10T08:04:42Z |
| format | Article |
| id | doaj.art-265a1d8f7dfd41fba63b18cd6b1ddbb3 |
| institution | Directory Open Access Journal |
| issn | 2673-4176 |
| language | English |
| last_indexed | 2024-03-10T08:04:42Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polysaccharides |
| spelling | doaj.art-265a1d8f7dfd41fba63b18cd6b1ddbb32023-11-22T11:07:07ZengMDPI AGPolysaccharides2673-41762021-06-012251953710.3390/polysaccharides2020031Trends of Chitosan Based Delivery Systems in Neuroregeneration and Functional Recovery in Spinal Cord InjuriesMallesh Kurakula0Shashank Gorityala1Devang B. Patel2Pratap Basim3Bhaumik Patel4Saurabh Kumar Jha5Department of Biomedical Engineering, The University of Memphis, Memphis, TN 38152, USADepartment of Bioanalytical Chemistry, Covance Laboratories, Madison, WI 53704, USADepartment of Pharmaceutical Sciences, Arnold and Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY 11201, USAThermo Fisher Scientific, Cincinnati, OH 45237, USAProduct Development Department, Cure Pharmaceutical Corporation, Los Angeles, CA 90025, USADepartment of Biotechnology, Sharda University, Greater Noida 201310, Uttar Pradesh, IndiaSpinal cord injury (SCI) is one of the most complicated nervous system injuries with challenging treatment and recovery. Regenerative biomaterials such as chitosan are being reported for their wide use in filling the cavities, deliver curative drugs, and also provide adsorption sites for transplanted stem cells. Biomaterial scaffolds utilizing chitosan have shown certain therapeutic effects on spinal cord injury repair with some limitations. Chitosan-based delivery in stem cell transplantation is another strategy that has shown decent success. Stem cells can be directed to differentiate into neurons or glia in vitro. Stem cell-based therapy, biopolymer chitosan delivery strategies, and scaffold-based therapeutic strategies have been advancing as a combinatorial approach for spinal cord injury repair. In this review, we summarize the recent progress in the treatment strategies of SCI due to the use of bioactivity of chitosan-based drug delivery systems. An emphasis on the role of chitosan in neural regeneration has also been highlighted.https://www.mdpi.com/2673-4176/2/2/31chitosanspinal cord injuryelectrospun scaffoldsnerve regenerationstem cell-based transplantation |
| spellingShingle | Mallesh Kurakula Shashank Gorityala Devang B. Patel Pratap Basim Bhaumik Patel Saurabh Kumar Jha Trends of Chitosan Based Delivery Systems in Neuroregeneration and Functional Recovery in Spinal Cord Injuries Polysaccharides chitosan spinal cord injury electrospun scaffolds nerve regeneration stem cell-based transplantation |
| title | Trends of Chitosan Based Delivery Systems in Neuroregeneration and Functional Recovery in Spinal Cord Injuries |
| title_full | Trends of Chitosan Based Delivery Systems in Neuroregeneration and Functional Recovery in Spinal Cord Injuries |
| title_fullStr | Trends of Chitosan Based Delivery Systems in Neuroregeneration and Functional Recovery in Spinal Cord Injuries |
| title_full_unstemmed | Trends of Chitosan Based Delivery Systems in Neuroregeneration and Functional Recovery in Spinal Cord Injuries |
| title_short | Trends of Chitosan Based Delivery Systems in Neuroregeneration and Functional Recovery in Spinal Cord Injuries |
| title_sort | trends of chitosan based delivery systems in neuroregeneration and functional recovery in spinal cord injuries |
| topic | chitosan spinal cord injury electrospun scaffolds nerve regeneration stem cell-based transplantation |
| url | https://www.mdpi.com/2673-4176/2/2/31 |
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