A Quantitative Analysis of Complexity of Human Pathogen-Specific CD4 T Cell Responses in Healthy M. tuberculosis Infected South Africans.

A Quantitative Analysis of Complexity of Human Pathogen-Specific CD4 T Cell Responses in Healthy M. tuberculosis Infected South Africans.

We performed a quantitative analysis of the HLA restriction, antigen and epitope specificity of human pathogen specific responses in healthy individuals infected with M. tuberculosis (Mtb), in a South African cohort as a test case. The results estimate the breadth of T cell responses for the first t...

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Bibliographic Details
Main Authors: Cecilia S Lindestam Arlehamn, Denise M McKinney, Chelsea Carpenter, Sinu Paul, Virginie Rozot, Edward Makgotlho, Yolande Gregg, Michele van Rooyen, Joel D Ernst, Mark Hatherill, Willem A Hanekom, Bjoern Peters, Thomas J Scriba, Alessandro Sette
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-07-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1005760

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https://doi.org/10.1371/journal.ppat.1005760

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