IL-18 Serum Levels in Patients with Obesity, Prediabetes and Newly Diagnosed Type 2 Diabetes
Background: Obesity and diabetes are related to a chronic low-grade inflammation. As a pro-inflammatory cytokine, IL-18 stimulates various cell types and has pleiotropic functions. Objective: To assess the levels of IL-18 in subjects from the entire spectrum of glycemic disorders. Methods: This stud...
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| Format: | Article |
| Language: | English |
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Shiraz University of Medical Sciences
2022-06-01
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| Series: | Iranian Journal of Immunology |
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| Online Access: | https://iji.sums.ac.ir/article_48523_a9ddec6b4bc690bfe4dd298952cf71ee.pdf |
| _version_ | 1811215963328086016 |
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| author | Iveta Nedeva Antoaneta Gateva Yavor Assyov Vera Karamfilova Julieta Hristova Kyosuke Yamanishi Zdravko Kamenov Haruki Okamura |
| author_facet | Iveta Nedeva Antoaneta Gateva Yavor Assyov Vera Karamfilova Julieta Hristova Kyosuke Yamanishi Zdravko Kamenov Haruki Okamura |
| author_sort | Iveta Nedeva |
| collection | DOAJ |
| description | Background: Obesity and diabetes are related to a chronic low-grade inflammation. As a pro-inflammatory cytokine, IL-18 stimulates various cell types and has pleiotropic functions. Objective: To assess the levels of IL-18 in subjects from the entire spectrum of glycemic disorders. Methods: This study included 387 Caucasians divided into four groups: healthy controls, obese subjects without carbohydrate issues, prediabetic patients, and recently discovered type 2 diabetics. Results: Subject with body mass index ≥30kg/m2 and glycemic disorders showed significantly higher levels of IL-18 (249.77 ± 89.96 pg/ml; 259.01 ± 95.70 pg/ml; and 340.98 ± 127.65 pg/ml) compared with that of the control group (219.47 ± 110.53 pg/ml, p < 0.05). IL-18 also had significant positive associations with some anthropometric parameters, liver enzymes, fasting, post-load glucose, insulin, uric acid, and triglycerides while negative with HDL. The circulating IL-18 levels for differentiating subjects with carbohydrate disturbances and those with metabolic syndrome were determined by ROC analysis. The AUC for the disturbances of the carbohydrate metabolism was 0.597 (p = 0.001; 95% CI = 0.539 - 0.654) and for MS AUC was 0.581 (p = 0.021; 95 % CI = 0.516 - 0.647). Conclusion: Our data indicate that as the levels of IL-18 are increased the carbohydrate tolerance is deteriorated. However, the significance of IL-18 in the progression of diabetes mellitus and subsequent consequences requires further exploration. |
| first_indexed | 2024-04-12T06:31:08Z |
| format | Article |
| id | doaj.art-2663f3fccc5246388f039142c0c60537 |
| institution | Directory Open Access Journal |
| issn | 1735-1383 1735-367X |
| language | English |
| last_indexed | 2024-04-12T06:31:08Z |
| publishDate | 2022-06-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Immunology |
| spelling | doaj.art-2663f3fccc5246388f039142c0c605372022-12-22T03:44:00ZengShiraz University of Medical SciencesIranian Journal of Immunology1735-13831735-367X2022-06-0119219920610.22034/iji.2022.90095.198748523IL-18 Serum Levels in Patients with Obesity, Prediabetes and Newly Diagnosed Type 2 DiabetesIveta Nedeva0Antoaneta Gateva1Yavor Assyov2Vera Karamfilova3Julieta Hristova4Kyosuke Yamanishi5Zdravko Kamenov6Haruki Okamura7Clinic of Endocrinology, University Hospital “Alexandrovska”, Department of Internal Medicine, Medical University-Sofia, BulgariaClinic of Endocrinology, University Hospital “Alexandrovska”, Department of Internal Medicine, Medical University-Sofia, BulgariaClinic of Endocrinology, University Hospital “Alexandrovska”, Department of Internal Medicine, Medical University-Sofia, BulgariaClinic of Endocrinology, University Hospital “Alexandrovska”, Department of Internal Medicine, Medical University-Sofia, BulgariaClinical Laboratory and Clinical Pharmacology, University Hospital “Alexandrovska”, Department of Clinical Laboratory, Medical University-Sofia, BulgariaDepartment of Psychoimmunology, Hyogo College of Medicine, JapanClinic of Endocrinology, University Hospital “Alexandrovska”, Department of Internal Medicine, Medical University-Sofia, BulgariaDepartment of Psychoimmunology, Hyogo College of Medicine, JapanBackground: Obesity and diabetes are related to a chronic low-grade inflammation. As a pro-inflammatory cytokine, IL-18 stimulates various cell types and has pleiotropic functions. Objective: To assess the levels of IL-18 in subjects from the entire spectrum of glycemic disorders. Methods: This study included 387 Caucasians divided into four groups: healthy controls, obese subjects without carbohydrate issues, prediabetic patients, and recently discovered type 2 diabetics. Results: Subject with body mass index ≥30kg/m2 and glycemic disorders showed significantly higher levels of IL-18 (249.77 ± 89.96 pg/ml; 259.01 ± 95.70 pg/ml; and 340.98 ± 127.65 pg/ml) compared with that of the control group (219.47 ± 110.53 pg/ml, p < 0.05). IL-18 also had significant positive associations with some anthropometric parameters, liver enzymes, fasting, post-load glucose, insulin, uric acid, and triglycerides while negative with HDL. The circulating IL-18 levels for differentiating subjects with carbohydrate disturbances and those with metabolic syndrome were determined by ROC analysis. The AUC for the disturbances of the carbohydrate metabolism was 0.597 (p = 0.001; 95% CI = 0.539 - 0.654) and for MS AUC was 0.581 (p = 0.021; 95 % CI = 0.516 - 0.647). Conclusion: Our data indicate that as the levels of IL-18 are increased the carbohydrate tolerance is deteriorated. However, the significance of IL-18 in the progression of diabetes mellitus and subsequent consequences requires further exploration.https://iji.sums.ac.ir/article_48523_a9ddec6b4bc690bfe4dd298952cf71ee.pdfcarbohydrate disturbancesil-18metabolic syndrome |
| spellingShingle | Iveta Nedeva Antoaneta Gateva Yavor Assyov Vera Karamfilova Julieta Hristova Kyosuke Yamanishi Zdravko Kamenov Haruki Okamura IL-18 Serum Levels in Patients with Obesity, Prediabetes and Newly Diagnosed Type 2 Diabetes Iranian Journal of Immunology carbohydrate disturbances il-18 metabolic syndrome |
| title | IL-18 Serum Levels in Patients with Obesity, Prediabetes and Newly Diagnosed Type 2 Diabetes |
| title_full | IL-18 Serum Levels in Patients with Obesity, Prediabetes and Newly Diagnosed Type 2 Diabetes |
| title_fullStr | IL-18 Serum Levels in Patients with Obesity, Prediabetes and Newly Diagnosed Type 2 Diabetes |
| title_full_unstemmed | IL-18 Serum Levels in Patients with Obesity, Prediabetes and Newly Diagnosed Type 2 Diabetes |
| title_short | IL-18 Serum Levels in Patients with Obesity, Prediabetes and Newly Diagnosed Type 2 Diabetes |
| title_sort | il 18 serum levels in patients with obesity prediabetes and newly diagnosed type 2 diabetes |
| topic | carbohydrate disturbances il-18 metabolic syndrome |
| url | https://iji.sums.ac.ir/article_48523_a9ddec6b4bc690bfe4dd298952cf71ee.pdf |
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