The predictive role of soluble programmed death ligand 1 in digestive system cancers
IntroductionThe prognostic role of soluble programmed death ligand 1 (sPD-L1) in digestive system cancers (DSCs) remains inconclusive. This study aimed to explore the predictive value of sPD-L1 expression in DSCs.MethodsComprehensive searches were run on the electronic databases (PubMed, Web of Scie...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1170220/full |
| _version_ | 1797780740611506176 |
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| author | Jian Ruan Zhihong Zhao Yuting Qian Ruilian Xu Guixiang Liao Feng-Ming (Spring) Kong Feng-Ming (Spring) Kong |
| author_facet | Jian Ruan Zhihong Zhao Yuting Qian Ruilian Xu Guixiang Liao Feng-Ming (Spring) Kong Feng-Ming (Spring) Kong |
| author_sort | Jian Ruan |
| collection | DOAJ |
| description | IntroductionThe prognostic role of soluble programmed death ligand 1 (sPD-L1) in digestive system cancers (DSCs) remains inconclusive. This study aimed to explore the predictive value of sPD-L1 expression in DSCs.MethodsComprehensive searches were run on the electronic databases (PubMed, Web of Science, EMBASE, and the Cochrane Library) to identify studies that assessed the prognostic role of sPD-L1 in DSCs. Review Manager software (version 5.3) was used for all analyses. Pooled data for survival outcomes were measured as hazard ratios (HRs), 95% confidence intervals (CIs), and odds ratios and their 95% CIs.ResultsThe search identified 18 studies involving 2,070 patients with DSCs. The meta-outcome revealed that a high level of sPD-L1 was related to poorer overall survival (HR, 3.06; 95% CI: 2.22–4.22, p<0.001) and disease-free survival (HR, 2.53; 95% CI: 1.67–3.83, p<0.001) in DSCs. Individually, the prognostic significance of high level of sPD-L1 expression was the highest in hepatic cell carcinoma (HR, 4.76; p<0.001) followed by gastric cancer (HR=3.55, p<0.001).ConclusionsPD-L1 may be a prognostic factor in DSCs for overall survival and disease-free survival. Inflammatory cytokines, treatment approaches, and other factors may affect the expression of sPD-L1. Therefore, the prognostic value of sPD-L1 for recurrence and metastasis should be further investigated. sPD-L1 may also predict response to treatment. Well-designed prospective studies with standard assessment methods should be conducted to determine the prognostic value of sPD-L1 in DSCs. |
| first_indexed | 2024-03-12T23:48:08Z |
| format | Article |
| id | doaj.art-2666471170d34e2da683cd73db3bf969 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-12T23:48:08Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-2666471170d34e2da683cd73db3bf9692023-07-14T01:47:14ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-07-011310.3389/fonc.2023.11702201170220The predictive role of soluble programmed death ligand 1 in digestive system cancersJian Ruan0Zhihong Zhao1Yuting Qian2Ruilian Xu3Guixiang Liao4Feng-Ming (Spring) Kong5Feng-Ming (Spring) Kong6The Second Clinical Medical College, Jinan University, Guangdong, ChinaDepartment of Nephrology, Shenzhen People’s Hospital, The Second Clinical Medical College, Jinan University, Guangdong, ChinaThe Second Clinical Medical College, Jinan University, Guangdong, ChinaThe Second Clinical Medical College, Jinan University, Guangdong, ChinaThe Second Clinical Medical College, Jinan University, Guangdong, ChinaDepartment of Clinical Oncology, Hong Kong University Shenzhen Hospital and Queen Mary Hospital, Hong Kong University Li Ka Shing Medical School, Hong Kong, Hong Kong SAR, ChinaDepartment of Clinical Oncology, Queen Mary Hospital, Hong Kong University Li Ka Shing Faculty of Medicine, Hong Kong, Hong Kong SR, ChinaIntroductionThe prognostic role of soluble programmed death ligand 1 (sPD-L1) in digestive system cancers (DSCs) remains inconclusive. This study aimed to explore the predictive value of sPD-L1 expression in DSCs.MethodsComprehensive searches were run on the electronic databases (PubMed, Web of Science, EMBASE, and the Cochrane Library) to identify studies that assessed the prognostic role of sPD-L1 in DSCs. Review Manager software (version 5.3) was used for all analyses. Pooled data for survival outcomes were measured as hazard ratios (HRs), 95% confidence intervals (CIs), and odds ratios and their 95% CIs.ResultsThe search identified 18 studies involving 2,070 patients with DSCs. The meta-outcome revealed that a high level of sPD-L1 was related to poorer overall survival (HR, 3.06; 95% CI: 2.22–4.22, p<0.001) and disease-free survival (HR, 2.53; 95% CI: 1.67–3.83, p<0.001) in DSCs. Individually, the prognostic significance of high level of sPD-L1 expression was the highest in hepatic cell carcinoma (HR, 4.76; p<0.001) followed by gastric cancer (HR=3.55, p<0.001).ConclusionsPD-L1 may be a prognostic factor in DSCs for overall survival and disease-free survival. Inflammatory cytokines, treatment approaches, and other factors may affect the expression of sPD-L1. Therefore, the prognostic value of sPD-L1 for recurrence and metastasis should be further investigated. sPD-L1 may also predict response to treatment. Well-designed prospective studies with standard assessment methods should be conducted to determine the prognostic value of sPD-L1 in DSCs.https://www.frontiersin.org/articles/10.3389/fonc.2023.1170220/fulldigestive system cancersoverall survivalprognosissoluble programmed death ligand 1gastric cancer |
| spellingShingle | Jian Ruan Zhihong Zhao Yuting Qian Ruilian Xu Guixiang Liao Feng-Ming (Spring) Kong Feng-Ming (Spring) Kong The predictive role of soluble programmed death ligand 1 in digestive system cancers Frontiers in Oncology digestive system cancers overall survival prognosis soluble programmed death ligand 1 gastric cancer |
| title | The predictive role of soluble programmed death ligand 1 in digestive system cancers |
| title_full | The predictive role of soluble programmed death ligand 1 in digestive system cancers |
| title_fullStr | The predictive role of soluble programmed death ligand 1 in digestive system cancers |
| title_full_unstemmed | The predictive role of soluble programmed death ligand 1 in digestive system cancers |
| title_short | The predictive role of soluble programmed death ligand 1 in digestive system cancers |
| title_sort | predictive role of soluble programmed death ligand 1 in digestive system cancers |
| topic | digestive system cancers overall survival prognosis soluble programmed death ligand 1 gastric cancer |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1170220/full |
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