Radiopharmaceuticals for PET and SPECT Imaging: A Literature Review over the Last Decade
Positron emission tomography (PET) uses radioactive tracers and enables the functional imaging of several metabolic processes, blood flow measurements, regional chemical composition, and/or chemical absorption. Depending on the targeted processes within the living organism, different tracers are use...
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| Format: | Article |
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MDPI AG
2022-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/9/5023 |
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| author | George Crișan Nastasia Sanda Moldovean-Cioroianu Diana-Gabriela Timaru Gabriel Andrieș Călin Căinap Vasile Chiș |
| author_facet | George Crișan Nastasia Sanda Moldovean-Cioroianu Diana-Gabriela Timaru Gabriel Andrieș Călin Căinap Vasile Chiș |
| author_sort | George Crișan |
| collection | DOAJ |
| description | Positron emission tomography (PET) uses radioactive tracers and enables the functional imaging of several metabolic processes, blood flow measurements, regional chemical composition, and/or chemical absorption. Depending on the targeted processes within the living organism, different tracers are used for various medical conditions, such as cancer, particular brain pathologies, cardiac events, and bone lesions, where the most commonly used tracers are radiolabeled with 18F (e.g., [<sup>18</sup>F]-FDG and NA [<sup>18</sup>F]). Oxygen-15 isotope is mostly involved in blood flow measurements, whereas a wide array of <sup>11</sup>C-based compounds have also been developed for neuronal disorders according to the affected neuroreceptors, prostate cancer, and lung carcinomas. In contrast, the single-photon emission computed tomography (SPECT) technique uses gamma-emitting radioisotopes and can be used to diagnose strokes, seizures, bone illnesses, and infections by gauging the blood flow and radio distribution within tissues and organs. The radioisotopes typically used in SPECT imaging are iodine-123, technetium-99m, xenon-133, thallium-201, and indium-111. This systematic review article aims to clarify and disseminate the available scientific literature focused on PET/SPECT radiotracers and to provide an overview of the conducted research within the past decade, with an additional focus on the novel radiopharmaceuticals developed for medical imaging. |
| first_indexed | 2024-03-10T04:04:04Z |
| format | Article |
| id | doaj.art-26666db11e77448684fe8860e03940b1 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T04:04:04Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-26666db11e77448684fe8860e03940b12023-11-23T08:25:52ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-04-01239502310.3390/ijms23095023Radiopharmaceuticals for PET and SPECT Imaging: A Literature Review over the Last DecadeGeorge Crișan0Nastasia Sanda Moldovean-Cioroianu1Diana-Gabriela Timaru2Gabriel Andrieș3Călin Căinap4Vasile Chiș5Faculty of Physics, Babeş-Bolyai University, Str. M. Kogălniceanu 1, 400084 Cluj-Napoca, RomaniaFaculty of Physics, Babeş-Bolyai University, Str. M. Kogălniceanu 1, 400084 Cluj-Napoca, RomaniaFaculty of Physics, Babeş-Bolyai University, Str. M. Kogălniceanu 1, 400084 Cluj-Napoca, RomaniaDepartment of Nuclear Medicine, County Clinical Hospital, Clinicilor 3-5, 400006 Cluj-Napoca, RomaniaThe Oncology Institute “Prof. Dr. Ion Chiricuţă”, Republicii 34-36, 400015 Cluj-Napoca, RomaniaFaculty of Physics, Babeş-Bolyai University, Str. M. Kogălniceanu 1, 400084 Cluj-Napoca, RomaniaPositron emission tomography (PET) uses radioactive tracers and enables the functional imaging of several metabolic processes, blood flow measurements, regional chemical composition, and/or chemical absorption. Depending on the targeted processes within the living organism, different tracers are used for various medical conditions, such as cancer, particular brain pathologies, cardiac events, and bone lesions, where the most commonly used tracers are radiolabeled with 18F (e.g., [<sup>18</sup>F]-FDG and NA [<sup>18</sup>F]). Oxygen-15 isotope is mostly involved in blood flow measurements, whereas a wide array of <sup>11</sup>C-based compounds have also been developed for neuronal disorders according to the affected neuroreceptors, prostate cancer, and lung carcinomas. In contrast, the single-photon emission computed tomography (SPECT) technique uses gamma-emitting radioisotopes and can be used to diagnose strokes, seizures, bone illnesses, and infections by gauging the blood flow and radio distribution within tissues and organs. The radioisotopes typically used in SPECT imaging are iodine-123, technetium-99m, xenon-133, thallium-201, and indium-111. This systematic review article aims to clarify and disseminate the available scientific literature focused on PET/SPECT radiotracers and to provide an overview of the conducted research within the past decade, with an additional focus on the novel radiopharmaceuticals developed for medical imaging.https://www.mdpi.com/1422-0067/23/9/5023PETSPECTradiopharmaceuticalstracersmolecular imagingreview |
| spellingShingle | George Crișan Nastasia Sanda Moldovean-Cioroianu Diana-Gabriela Timaru Gabriel Andrieș Călin Căinap Vasile Chiș Radiopharmaceuticals for PET and SPECT Imaging: A Literature Review over the Last Decade International Journal of Molecular Sciences PET SPECT radiopharmaceuticals tracers molecular imaging review |
| title | Radiopharmaceuticals for PET and SPECT Imaging: A Literature Review over the Last Decade |
| title_full | Radiopharmaceuticals for PET and SPECT Imaging: A Literature Review over the Last Decade |
| title_fullStr | Radiopharmaceuticals for PET and SPECT Imaging: A Literature Review over the Last Decade |
| title_full_unstemmed | Radiopharmaceuticals for PET and SPECT Imaging: A Literature Review over the Last Decade |
| title_short | Radiopharmaceuticals for PET and SPECT Imaging: A Literature Review over the Last Decade |
| title_sort | radiopharmaceuticals for pet and spect imaging a literature review over the last decade |
| topic | PET SPECT radiopharmaceuticals tracers molecular imaging review |
| url | https://www.mdpi.com/1422-0067/23/9/5023 |
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