Bioaccessibility and Intestinal Transport of Tebuconazole in Table Grape by Using In Vitro Digestion Models
In this study, the effects of various digestive models, influencing factors and dietary supplements on the bioaccessibility of tebuconazole in table grapes were compared. The Caco-2 cell model was employed to reveal the transfer behavior of tebuconazole. The results indicated that digestion time is...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-12-01
|
| Series: | Foods |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2304-8158/11/23/3926 |
| _version_ | 1797463193261441024 |
|---|---|
| author | Xiaowei Liu Ying Han Ouli Xiao Weiye Cui Jieyin Chen Xiaofeng Dai Minmin Li Zhiqiang Kong |
| author_facet | Xiaowei Liu Ying Han Ouli Xiao Weiye Cui Jieyin Chen Xiaofeng Dai Minmin Li Zhiqiang Kong |
| author_sort | Xiaowei Liu |
| collection | DOAJ |
| description | In this study, the effects of various digestive models, influencing factors and dietary supplements on the bioaccessibility of tebuconazole in table grapes were compared. The Caco-2 cell model was employed to reveal the transfer behavior of tebuconazole. The results indicated that digestion time is the main factor affecting bioaccessibility. With an increase in time, the tebuconazole in grapes was almost completely dissolved, with bioaccessibility reaching 98.5%, whereas dietary fiber reduced bioaccessibility. Tebuconazole undergoes carrier-free passive transport in permeable cells in the Caco-2 cell model. These findings have practical application value for correctly evaluating the harmful level of pollutants in the matrix to human body. |
| first_indexed | 2024-03-09T17:47:12Z |
| format | Article |
| id | doaj.art-266728d618d4473792483970a5eb2790 |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-09T17:47:12Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-266728d618d4473792483970a5eb27902023-11-24T11:00:56ZengMDPI AGFoods2304-81582022-12-011123392610.3390/foods11233926Bioaccessibility and Intestinal Transport of Tebuconazole in Table Grape by Using In Vitro Digestion ModelsXiaowei Liu0Ying Han1Ouli Xiao2Weiye Cui3Jieyin Chen4Xiaofeng Dai5Minmin Li6Zhiqiang Kong7State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, ChinaState Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, ChinaState Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, ChinaKey Laboratory of Agro-Products Quality and Safety Control in Storage and Transport Process, Ministry of Agriculture and Rural Affairs/Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193, ChinaState Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, ChinaState Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, ChinaKey Laboratory of Agro-Products Quality and Safety Control in Storage and Transport Process, Ministry of Agriculture and Rural Affairs/Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193, ChinaState Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, ChinaIn this study, the effects of various digestive models, influencing factors and dietary supplements on the bioaccessibility of tebuconazole in table grapes were compared. The Caco-2 cell model was employed to reveal the transfer behavior of tebuconazole. The results indicated that digestion time is the main factor affecting bioaccessibility. With an increase in time, the tebuconazole in grapes was almost completely dissolved, with bioaccessibility reaching 98.5%, whereas dietary fiber reduced bioaccessibility. Tebuconazole undergoes carrier-free passive transport in permeable cells in the Caco-2 cell model. These findings have practical application value for correctly evaluating the harmful level of pollutants in the matrix to human body.https://www.mdpi.com/2304-8158/11/23/3926grapefungicidein vitro modelbioaccessibilityCaco-2 cells |
| spellingShingle | Xiaowei Liu Ying Han Ouli Xiao Weiye Cui Jieyin Chen Xiaofeng Dai Minmin Li Zhiqiang Kong Bioaccessibility and Intestinal Transport of Tebuconazole in Table Grape by Using In Vitro Digestion Models Foods grape fungicide in vitro model bioaccessibility Caco-2 cells |
| title | Bioaccessibility and Intestinal Transport of Tebuconazole in Table Grape by Using In Vitro Digestion Models |
| title_full | Bioaccessibility and Intestinal Transport of Tebuconazole in Table Grape by Using In Vitro Digestion Models |
| title_fullStr | Bioaccessibility and Intestinal Transport of Tebuconazole in Table Grape by Using In Vitro Digestion Models |
| title_full_unstemmed | Bioaccessibility and Intestinal Transport of Tebuconazole in Table Grape by Using In Vitro Digestion Models |
| title_short | Bioaccessibility and Intestinal Transport of Tebuconazole in Table Grape by Using In Vitro Digestion Models |
| title_sort | bioaccessibility and intestinal transport of tebuconazole in table grape by using in vitro digestion models |
| topic | grape fungicide in vitro model bioaccessibility Caco-2 cells |
| url | https://www.mdpi.com/2304-8158/11/23/3926 |
| work_keys_str_mv | AT xiaoweiliu bioaccessibilityandintestinaltransportoftebuconazoleintablegrapebyusinginvitrodigestionmodels AT yinghan bioaccessibilityandintestinaltransportoftebuconazoleintablegrapebyusinginvitrodigestionmodels AT oulixiao bioaccessibilityandintestinaltransportoftebuconazoleintablegrapebyusinginvitrodigestionmodels AT weiyecui bioaccessibilityandintestinaltransportoftebuconazoleintablegrapebyusinginvitrodigestionmodels AT jieyinchen bioaccessibilityandintestinaltransportoftebuconazoleintablegrapebyusinginvitrodigestionmodels AT xiaofengdai bioaccessibilityandintestinaltransportoftebuconazoleintablegrapebyusinginvitrodigestionmodels AT minminli bioaccessibilityandintestinaltransportoftebuconazoleintablegrapebyusinginvitrodigestionmodels AT zhiqiangkong bioaccessibilityandintestinaltransportoftebuconazoleintablegrapebyusinginvitrodigestionmodels |