Structures and Biological Activities of Secondary Metabolites from <i>Xylaria</i> spp.
The fungus genus <i>Xylaria</i> is an important source of drug discoveries in scientific fields and in the pharmaceutical industry due to its potential to produce a variety of structured novel and bioactive secondary metabolites. This review prioritizes the structures of the secondary me...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Journal of Fungi |
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| Online Access: | https://www.mdpi.com/2309-608X/10/3/190 |
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| author | Weikang Chen Miao Yu Shiji Chen Tianmi Gong Linlin Xie Jinqin Liu Chang Bian Guolei Huang Caijuan Zheng |
| author_facet | Weikang Chen Miao Yu Shiji Chen Tianmi Gong Linlin Xie Jinqin Liu Chang Bian Guolei Huang Caijuan Zheng |
| author_sort | Weikang Chen |
| collection | DOAJ |
| description | The fungus genus <i>Xylaria</i> is an important source of drug discoveries in scientific fields and in the pharmaceutical industry due to its potential to produce a variety of structured novel and bioactive secondary metabolites. This review prioritizes the structures of the secondary metabolites of <i>Xylaria</i> spp. from 1994 to January 2024 and their relevant biological activities. A total of 445 new compounds, including terpenoids, nitrogen-containing compounds, polyketides, lactones, and other classes, are presented in this review. Remarkably, among these compounds, 177 compounds show various biological activities, including cytotoxic, antimicrobial, anti-inflammatory, antifungal, immunosuppressive, and enzyme-inhibitory activities. This paper will guide further investigations into the structures of novel and potent active natural products derived from <i>Xylaria</i> and their potential contributions to the future development of new natural drug products in the agricultural and medicinal fields. |
| first_indexed | 2024-04-24T18:06:43Z |
| format | Article |
| id | doaj.art-2667bfe1c1ca4a4a8871f628a2a7d5c4 |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-04-24T18:06:43Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-2667bfe1c1ca4a4a8871f628a2a7d5c42024-03-27T13:49:39ZengMDPI AGJournal of Fungi2309-608X2024-02-0110319010.3390/jof10030190Structures and Biological Activities of Secondary Metabolites from <i>Xylaria</i> spp.Weikang Chen0Miao Yu1Shiji Chen2Tianmi Gong3Linlin Xie4Jinqin Liu5Chang Bian6Guolei Huang7Caijuan Zheng8Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, ChinaKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, ChinaKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, ChinaKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, ChinaKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, ChinaKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, ChinaKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, ChinaKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, ChinaKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, ChinaThe fungus genus <i>Xylaria</i> is an important source of drug discoveries in scientific fields and in the pharmaceutical industry due to its potential to produce a variety of structured novel and bioactive secondary metabolites. This review prioritizes the structures of the secondary metabolites of <i>Xylaria</i> spp. from 1994 to January 2024 and their relevant biological activities. A total of 445 new compounds, including terpenoids, nitrogen-containing compounds, polyketides, lactones, and other classes, are presented in this review. Remarkably, among these compounds, 177 compounds show various biological activities, including cytotoxic, antimicrobial, anti-inflammatory, antifungal, immunosuppressive, and enzyme-inhibitory activities. This paper will guide further investigations into the structures of novel and potent active natural products derived from <i>Xylaria</i> and their potential contributions to the future development of new natural drug products in the agricultural and medicinal fields.https://www.mdpi.com/2309-608X/10/3/190<i>Xylaria</i> sp.secondary metabolitesbioactivity |
| spellingShingle | Weikang Chen Miao Yu Shiji Chen Tianmi Gong Linlin Xie Jinqin Liu Chang Bian Guolei Huang Caijuan Zheng Structures and Biological Activities of Secondary Metabolites from <i>Xylaria</i> spp. Journal of Fungi <i>Xylaria</i> sp. secondary metabolites bioactivity |
| title | Structures and Biological Activities of Secondary Metabolites from <i>Xylaria</i> spp. |
| title_full | Structures and Biological Activities of Secondary Metabolites from <i>Xylaria</i> spp. |
| title_fullStr | Structures and Biological Activities of Secondary Metabolites from <i>Xylaria</i> spp. |
| title_full_unstemmed | Structures and Biological Activities of Secondary Metabolites from <i>Xylaria</i> spp. |
| title_short | Structures and Biological Activities of Secondary Metabolites from <i>Xylaria</i> spp. |
| title_sort | structures and biological activities of secondary metabolites from i xylaria i spp |
| topic | <i>Xylaria</i> sp. secondary metabolites bioactivity |
| url | https://www.mdpi.com/2309-608X/10/3/190 |
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