Amplification of the angiogenic signal through the activation of the TSC/mTOR/HIF axis by the KSHV vGPCR in Kaposi's sarcoma.

Amplification of the angiogenic signal through the activation of the TSC/mTOR/HIF axis by the KSHV vGPCR in Kaposi's sarcoma.

Kaposi's sarcoma (KS) is a vascular neoplasm characterized by the dysregulated expression of angiogenic and inflammatory cytokines. The driving force of the KS lesion, the KSHV-infected spindle cell, secretes elevated levels of vascular endothelial growth factor (VEGF), essential for KS develop...

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Bibliographic Details
Main Authors: Bruno C Jham, Tao Ma, Jiadi Hu, Risa Chaisuparat, Eitan R Friedman, Pier Paolo Pandolfi, Abraham Schneider, Akrit Sodhi, Silvia Montaner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3084756?pdf=render

Internet

http://europepmc.org/articles/PMC3084756?pdf=render

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