Deregulated MITF sumoylation: A route to melanoma
Metastatic melanoma is a deadly form of skin cancer. Extraordinary breakthroughs have been recently achieved in the treatment of the disease, leading to objective increase in patient survival. However, early detection of potential dangerous melanocytic lesions remains the best strategy to avoid meta...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-07-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2017.1331154 |
| _version_ | 1797677195463753728 |
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| author | Robert Ballotti Corine Bertolotto |
| author_facet | Robert Ballotti Corine Bertolotto |
| author_sort | Robert Ballotti |
| collection | DOAJ |
| description | Metastatic melanoma is a deadly form of skin cancer. Extraordinary breakthroughs have been recently achieved in the treatment of the disease, leading to objective increase in patient survival. However, early detection of potential dangerous melanocytic lesions remains the best strategy to avoid metastatic dissemination, which is still the main cause of death in melanoma patients. In 2011, our team identified a germline mutation in microphthalmia-associated transcription factor (MITFE318K) that predisposes carriers to melanoma. Recently, we demonstrated that this mutation interfered with oncogene-induced senescence, one of the first events that should be overcome to allow melanoma development. Therefore, our works provide important clues on the early steps of melanomagenesis and as such might be useful for prevention or early therapeutic interventions in at risk-patients. |
| first_indexed | 2024-03-11T22:41:32Z |
| format | Article |
| id | doaj.art-26692ca7a1cc4f158d3d5803d9e6e2ec |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:41:32Z |
| publishDate | 2017-07-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-26692ca7a1cc4f158d3d5803d9e6e2ec2023-09-22T09:10:58ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562017-07-014410.1080/23723556.2017.13311541331154Deregulated MITF sumoylation: A route to melanomaRobert Ballotti0Corine Bertolotto1INSERMINSERMMetastatic melanoma is a deadly form of skin cancer. Extraordinary breakthroughs have been recently achieved in the treatment of the disease, leading to objective increase in patient survival. However, early detection of potential dangerous melanocytic lesions remains the best strategy to avoid metastatic dissemination, which is still the main cause of death in melanoma patients. In 2011, our team identified a germline mutation in microphthalmia-associated transcription factor (MITFE318K) that predisposes carriers to melanoma. Recently, we demonstrated that this mutation interfered with oncogene-induced senescence, one of the first events that should be overcome to allow melanoma development. Therefore, our works provide important clues on the early steps of melanomagenesis and as such might be useful for prevention or early therapeutic interventions in at risk-patients.http://dx.doi.org/10.1080/23723556.2017.1331154melanomamitfsenescence |
| spellingShingle | Robert Ballotti Corine Bertolotto Deregulated MITF sumoylation: A route to melanoma Molecular & Cellular Oncology melanoma mitf senescence |
| title | Deregulated MITF sumoylation: A route to melanoma |
| title_full | Deregulated MITF sumoylation: A route to melanoma |
| title_fullStr | Deregulated MITF sumoylation: A route to melanoma |
| title_full_unstemmed | Deregulated MITF sumoylation: A route to melanoma |
| title_short | Deregulated MITF sumoylation: A route to melanoma |
| title_sort | deregulated mitf sumoylation a route to melanoma |
| topic | melanoma mitf senescence |
| url | http://dx.doi.org/10.1080/23723556.2017.1331154 |
| work_keys_str_mv | AT robertballotti deregulatedmitfsumoylationaroutetomelanoma AT corinebertolotto deregulatedmitfsumoylationaroutetomelanoma |