Comparison between the conventional method and a portable device for determination of INR
CONTEXT: Anticoagulation with warfarin is considered the appropriate treatment for venous thromboembolism and other thrombotic pathologies. Regular INR control is required for dosage adjustment and therapeutic control. Use of portable monitoring systems optimizes management of these patients. OBJ...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Angiologia e de Cirurgia Vascular (SBACV)
2014-04-01
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| Series: | Jornal Vascular Brasileiro |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-54492014000200088&lng=en&tlng=en |
| _version_ | 1819263170681765888 |
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| author | André Camacho Oliveira Araújo Rodrigo Borges Domingues Bonno van Bellen |
| author_facet | André Camacho Oliveira Araújo Rodrigo Borges Domingues Bonno van Bellen |
| author_sort | André Camacho Oliveira Araújo |
| collection | DOAJ |
| description | CONTEXT: Anticoagulation with warfarin is considered the appropriate treatment for venous thromboembolism and other thrombotic pathologies. Regular INR control is required for dosage adjustment and therapeutic control. Use of portable monitoring systems optimizes management of these patients. OBJECTIVE: To compare INR measurements taken using the portable Coaguchek XS system in capillary blood with the standard laboratory method using venous blood. METHOD: Fifty-two samples each of venous and capillary blood were collected from nineteen patients on warfarin, who had been admitted to the Hospital da Beneficência Portuguesa de São Paulo, and analyzed using the conventional method and the Coaguchek XS system, respectively. RESULTS: Spearman's correlation coefficient ® for the overall performance of the two methods was 0.978 (p<0.0001; 95%CI 0.961-0.988). The Kappa measure of agreement for all patients was 76.8% (p<0.001; IC: 95% 0.975-0.561). Mean INR according to the Coaguchek XS system underestimated the values provided by the conventional method by -0.01 INR points, with a standard error of 0.342. Results for INR values greater than 3.5 were satisfactory with a correlation coefficient of 0.71, but without statistical significance (p>0.714). CONCLUSIONS: The Coaguchek XS system can be used to monitor prothrombin time in patients on oral anticoagulants, provided INR values greater than 3.5 are confirmed using the conventional laboratory method. |
| first_indexed | 2024-12-23T20:09:20Z |
| format | Article |
| id | doaj.art-2669d198821147d6a87377704130bba0 |
| institution | Directory Open Access Journal |
| issn | 1677-7301 |
| language | English |
| last_indexed | 2024-12-23T20:09:20Z |
| publishDate | 2014-04-01 |
| publisher | Sociedade Brasileira de Angiologia e de Cirurgia Vascular (SBACV) |
| record_format | Article |
| series | Jornal Vascular Brasileiro |
| spelling | doaj.art-2669d198821147d6a87377704130bba02022-12-21T17:32:51ZengSociedade Brasileira de Angiologia e de Cirurgia Vascular (SBACV)Jornal Vascular Brasileiro1677-73012014-04-01132889310.1590/jvb.2014.051S1677-54492014000200088Comparison between the conventional method and a portable device for determination of INRAndré Camacho Oliveira AraújoRodrigo Borges DominguesBonno van BellenCONTEXT: Anticoagulation with warfarin is considered the appropriate treatment for venous thromboembolism and other thrombotic pathologies. Regular INR control is required for dosage adjustment and therapeutic control. Use of portable monitoring systems optimizes management of these patients. OBJECTIVE: To compare INR measurements taken using the portable Coaguchek XS system in capillary blood with the standard laboratory method using venous blood. METHOD: Fifty-two samples each of venous and capillary blood were collected from nineteen patients on warfarin, who had been admitted to the Hospital da Beneficência Portuguesa de São Paulo, and analyzed using the conventional method and the Coaguchek XS system, respectively. RESULTS: Spearman's correlation coefficient ® for the overall performance of the two methods was 0.978 (p<0.0001; 95%CI 0.961-0.988). The Kappa measure of agreement for all patients was 76.8% (p<0.001; IC: 95% 0.975-0.561). Mean INR according to the Coaguchek XS system underestimated the values provided by the conventional method by -0.01 INR points, with a standard error of 0.342. Results for INR values greater than 3.5 were satisfactory with a correlation coefficient of 0.71, but without statistical significance (p>0.714). CONCLUSIONS: The Coaguchek XS system can be used to monitor prothrombin time in patients on oral anticoagulants, provided INR values greater than 3.5 are confirmed using the conventional laboratory method.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-54492014000200088&lng=en&tlng=entempo de protrombinacoagulação sanguíneavarfarinatromboembolismo venoso |
| spellingShingle | André Camacho Oliveira Araújo Rodrigo Borges Domingues Bonno van Bellen Comparison between the conventional method and a portable device for determination of INR Jornal Vascular Brasileiro tempo de protrombina coagulação sanguínea varfarina tromboembolismo venoso |
| title | Comparison between the conventional method and a portable device for determination of INR |
| title_full | Comparison between the conventional method and a portable device for determination of INR |
| title_fullStr | Comparison between the conventional method and a portable device for determination of INR |
| title_full_unstemmed | Comparison between the conventional method and a portable device for determination of INR |
| title_short | Comparison between the conventional method and a portable device for determination of INR |
| title_sort | comparison between the conventional method and a portable device for determination of inr |
| topic | tempo de protrombina coagulação sanguínea varfarina tromboembolismo venoso |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-54492014000200088&lng=en&tlng=en |
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