Vitamin C for COVID-19: A living systematic review
Objective This living systematic review aims to provide a timely, rigorous, and continuously updated summary of the available evidence on the role of vitamin C in treating patients with COVID-19. Data sources We conducted searches in PubMed/MEDLINE, Embase, Cochrane Central Register of Controll...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Medwave Estudios Limitada
2020-07-01
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| Series: | Medwave |
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| Online Access: | https://www.medwave.cl/link.cgi/Medwave/Estudios/RevSistematicas/7979.act |
| _version_ | 1818387934370332672 |
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| author | Eduard Baladia Ana Beatriz Pizarro Luis Ortiz-Muñoz Gabriel Rada |
| author_facet | Eduard Baladia Ana Beatriz Pizarro Luis Ortiz-Muñoz Gabriel Rada |
| author_sort | Eduard Baladia |
| collection | DOAJ |
| description | Objective
This living systematic review aims to provide a timely, rigorous, and continuously updated summary of the available evidence on the role of vitamin C in treating patients with COVID-19.
Data sources
We conducted searches in PubMed/MEDLINE, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), grey literature, and in a centralized repository in L·OVE (Living OVerview of Evidence). In response to the COVID-19 emergency, L·OVE was adapted to expand the range of evidence it comprises and has been customized to group all COVID-19 evidence in one place. All the searches covered the period until April 29, 2020 (one day before submission).
Study selection and methods
We adapted an already published standard protocol for multiple parallel systematic reviews. We searched for randomized trials evaluating the effect, in patients with COVID-19, of vitamin C versus placebo or no treatment. Anticipating the lack of randomized trials directly addressing this question, we also searched for trials evaluating MERS-CoV and SARS-CoV, and non-randomized studies in COVID-19. Two reviewers independently screened each study for eligibility. A living, web-based version of this review will be openly available during the COVID-19 pandemic, and we will resubmit it to the journal whenever there are substantial updates.
Results
We screened 95 records, but no study was considered eligible. We identified 20 ongoing studies, including 13 randomized trials evaluating vitamin C in COVID-19.
Conclusions
We did not find any studies that met our inclusion criteria, and hence there is no evidence to support or refute the use of vitamin C in the treatment of patients with COVID-19. A substantial number of ongoing studies should provide valuable evidence to inform researchers and decision-makers soon.
PROSPERO Registration number
CRD42020181216 |
| first_indexed | 2024-12-14T04:17:50Z |
| format | Article |
| id | doaj.art-2669f989699645d082abc0648325792e |
| institution | Directory Open Access Journal |
| issn | 0717-6384 0717-6384 |
| language | English |
| last_indexed | 2024-12-14T04:17:50Z |
| publishDate | 2020-07-01 |
| publisher | Medwave Estudios Limitada |
| record_format | Article |
| series | Medwave |
| spelling | doaj.art-2669f989699645d082abc0648325792e2022-12-21T23:17:29ZengMedwave Estudios LimitadaMedwave0717-63840717-63842020-07-012006e7978e797810.5867/medwave.2020.06.7978Vitamin C for COVID-19: A living systematic reviewEduard Baladia0Ana Beatriz Pizarro1Luis Ortiz-Muñoz2Gabriel Rada3Red de Nutrición Basada en la Evidencia, Academia Española de Nutrición y Dietética, Pamplona, EspañaDepartamento de Epidemiología Clínica y Bioestadística, Pontificia Universidad Javeriana, Bogotá, ColombiaUC Evidence Center, Cochrane Chile Associated Center, Pontificia Universidad Católica de Chile, Santiago, ChileUC Evidence Center, Cochrane Chile Associated Center, Pontificia Universidad Católica de Chile, Santiago, Chile; Fundación Epistemonikos, Santiago, Chile; Internal Medicine Department, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago, ChileObjective This living systematic review aims to provide a timely, rigorous, and continuously updated summary of the available evidence on the role of vitamin C in treating patients with COVID-19. Data sources We conducted searches in PubMed/MEDLINE, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), grey literature, and in a centralized repository in L·OVE (Living OVerview of Evidence). In response to the COVID-19 emergency, L·OVE was adapted to expand the range of evidence it comprises and has been customized to group all COVID-19 evidence in one place. All the searches covered the period until April 29, 2020 (one day before submission). Study selection and methods We adapted an already published standard protocol for multiple parallel systematic reviews. We searched for randomized trials evaluating the effect, in patients with COVID-19, of vitamin C versus placebo or no treatment. Anticipating the lack of randomized trials directly addressing this question, we also searched for trials evaluating MERS-CoV and SARS-CoV, and non-randomized studies in COVID-19. Two reviewers independently screened each study for eligibility. A living, web-based version of this review will be openly available during the COVID-19 pandemic, and we will resubmit it to the journal whenever there are substantial updates. Results We screened 95 records, but no study was considered eligible. We identified 20 ongoing studies, including 13 randomized trials evaluating vitamin C in COVID-19. Conclusions We did not find any studies that met our inclusion criteria, and hence there is no evidence to support or refute the use of vitamin C in the treatment of patients with COVID-19. A substantial number of ongoing studies should provide valuable evidence to inform researchers and decision-makers soon. PROSPERO Registration number CRD42020181216https://www.medwave.cl/link.cgi/Medwave/Estudios/RevSistematicas/7979.actcovid-19severe acute respiratory syndrome coronavirus 2coronavirus diseasecoronavirus infectionssystematic reviewascorbic acidvitamin c |
| spellingShingle | Eduard Baladia Ana Beatriz Pizarro Luis Ortiz-Muñoz Gabriel Rada Vitamin C for COVID-19: A living systematic review Medwave covid-19 severe acute respiratory syndrome coronavirus 2 coronavirus disease coronavirus infections systematic review ascorbic acid vitamin c |
| title | Vitamin C for COVID-19: A living systematic review |
| title_full | Vitamin C for COVID-19: A living systematic review |
| title_fullStr | Vitamin C for COVID-19: A living systematic review |
| title_full_unstemmed | Vitamin C for COVID-19: A living systematic review |
| title_short | Vitamin C for COVID-19: A living systematic review |
| title_sort | vitamin c for covid 19 a living systematic review |
| topic | covid-19 severe acute respiratory syndrome coronavirus 2 coronavirus disease coronavirus infections systematic review ascorbic acid vitamin c |
| url | https://www.medwave.cl/link.cgi/Medwave/Estudios/RevSistematicas/7979.act |
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